Homotypic cell cannibalism, a cell‐death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer
Abstract Pancreatic adenocarcinoma (PDAC) is an extremely deadly disease for which all treatments available have failed to improve life expectancy significantly. This may be explained by the high metastatic potential of PDAC cells, which results from their dedifferentiation towards a mesenchymal phe...
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| Format: | Article |
| Language: | English |
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Springer Nature
2012-07-01
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| Series: | EMBO Molecular Medicine |
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| Online Access: | https://doi.org/10.1002/emmm.201201255 |
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| author | Carla E. Cano María José Sandí Tewfik Hamidi Ezequiel L. Calvo Olivier Turrini Laurent Bartholin Céline Loncle Véronique Secq Stéphane Garcia Gwen Lomberk Guido Kroemer Raul Urrutia Juan L. Iovanna |
| author_facet | Carla E. Cano María José Sandí Tewfik Hamidi Ezequiel L. Calvo Olivier Turrini Laurent Bartholin Céline Loncle Véronique Secq Stéphane Garcia Gwen Lomberk Guido Kroemer Raul Urrutia Juan L. Iovanna |
| author_sort | Carla E. Cano |
| collection | DOAJ |
| description | Abstract Pancreatic adenocarcinoma (PDAC) is an extremely deadly disease for which all treatments available have failed to improve life expectancy significantly. This may be explained by the high metastatic potential of PDAC cells, which results from their dedifferentiation towards a mesenchymal phenotype. Some PDAC present cell‐in‐cell structures whose origin and significance are currently unknown. We show here that cell‐in‐cells form after homotypic cell cannibalism (HoCC). We found PDAC patients whose tumours display HoCC develop less metastasis than those without. In vitro, HoCC was promoted by inactivation of the nuclear protein 1 (Nupr1), and was enhanced by treatment with transforming growth factor β. HoCC ends with death of PDAC cells, consistent with a metastasis suppressor role for this phenomenon. Hence, our data indicates a protective role for HoCC in PDAC and identifies Nupr1 as a molecular regulator of this process. |
| format | Article |
| id | doaj-art-96a83be0903c43bd9c05ceaec4178d60 |
| institution | OA Journals |
| issn | 1757-4676 1757-4684 |
| language | English |
| publishDate | 2012-07-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-96a83be0903c43bd9c05ceaec4178d602025-08-20T02:18:35ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842012-07-014996497910.1002/emmm.201201255Homotypic cell cannibalism, a cell‐death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancerCarla E. Cano0María José Sandí1Tewfik Hamidi2Ezequiel L. Calvo3Olivier Turrini4Laurent Bartholin5Céline Loncle6Véronique Secq7Stéphane Garcia8Gwen Lomberk9Guido Kroemer10Raul Urrutia11Juan L. Iovanna12INSERM U1068, CRCM, Cell StressINSERM U1068, CRCM, Cell StressINSERM U1068, CRCM, Cell StressMolecular Endocrinology and Oncology Research Center, CHUL Research CenterInstitut Paoli‐CalmettesINSERM U1052INSERM U1068, CRCM, Cell StressINSERM U1068, CRCM, Cell StressINSERM U1068, CRCM, Cell StressLaboratory of Epigenetics and Chromatin Dynamics, Gastroenterology Research Unit, Departments of Biochemistry and Molecular Biology, Biophysics, and Medicine, Mayo ClinicINSERM, U848Laboratory of Epigenetics and Chromatin Dynamics, Gastroenterology Research Unit, Departments of Biochemistry and Molecular Biology, Biophysics, and Medicine, Mayo ClinicINSERM U1068, CRCM, Cell StressAbstract Pancreatic adenocarcinoma (PDAC) is an extremely deadly disease for which all treatments available have failed to improve life expectancy significantly. This may be explained by the high metastatic potential of PDAC cells, which results from their dedifferentiation towards a mesenchymal phenotype. Some PDAC present cell‐in‐cell structures whose origin and significance are currently unknown. We show here that cell‐in‐cells form after homotypic cell cannibalism (HoCC). We found PDAC patients whose tumours display HoCC develop less metastasis than those without. In vitro, HoCC was promoted by inactivation of the nuclear protein 1 (Nupr1), and was enhanced by treatment with transforming growth factor β. HoCC ends with death of PDAC cells, consistent with a metastasis suppressor role for this phenomenon. Hence, our data indicates a protective role for HoCC in PDAC and identifies Nupr1 as a molecular regulator of this process.https://doi.org/10.1002/emmm.201201255cell cannibalismmetastasisNupr1pancreatic cancerTGFβ |
| spellingShingle | Carla E. Cano María José Sandí Tewfik Hamidi Ezequiel L. Calvo Olivier Turrini Laurent Bartholin Céline Loncle Véronique Secq Stéphane Garcia Gwen Lomberk Guido Kroemer Raul Urrutia Juan L. Iovanna Homotypic cell cannibalism, a cell‐death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer EMBO Molecular Medicine cell cannibalism metastasis Nupr1 pancreatic cancer TGFβ |
| title | Homotypic cell cannibalism, a cell‐death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer |
| title_full | Homotypic cell cannibalism, a cell‐death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer |
| title_fullStr | Homotypic cell cannibalism, a cell‐death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer |
| title_full_unstemmed | Homotypic cell cannibalism, a cell‐death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer |
| title_short | Homotypic cell cannibalism, a cell‐death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer |
| title_sort | homotypic cell cannibalism a cell death process regulated by the nuclear protein 1 opposes to metastasis in pancreatic cancer |
| topic | cell cannibalism metastasis Nupr1 pancreatic cancer TGFβ |
| url | https://doi.org/10.1002/emmm.201201255 |
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