Potential of Boronic Acid Derivatization and Activity in Agrochemical Discovery
Since the approval of Bortezomib (Velcade<sup>®</sup>) by the U.S. Food and Drug Administration (FDA) in 2003, boron-containing drugs have successfully entered the global market, spanning therapeutic areas such as anticancer, antibacterial, and antifungal agents. Meanwhile, boron is an e...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/30/14/3018 |
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| author | Liangshuo Ji Jianxin Wu Yachen Zuo Wenqiang Gao Jiyao Feng Zhenhua Zhang |
| author_facet | Liangshuo Ji Jianxin Wu Yachen Zuo Wenqiang Gao Jiyao Feng Zhenhua Zhang |
| author_sort | Liangshuo Ji |
| collection | DOAJ |
| description | Since the approval of Bortezomib (Velcade<sup>®</sup>) by the U.S. Food and Drug Administration (FDA) in 2003, boron-containing drugs have successfully entered the global market, spanning therapeutic areas such as anticancer, antibacterial, and antifungal agents. Meanwhile, boron is an essential trace element for plant growth, and boronic acid has been widely used as plant resistance inducers and growth promoters. In 2024, the Fungicide Resistance Action Committee (FRAC) introduced benzoxaboroles as a new category of fungicides, which fully demonstrates the significant application potential of boron-containing compounds (BCCs) in the field of agricultural fungicides. Recently, studies on BCCs in agriculture have emerged continuously. Compared with the systematic reviews in the pharmaceutical field, those focusing on BCCs in agriculture remain absent. This review systematically collates BCCs with reported biological activities from the literature over the past 20 years, from the perspective of boron-containing building blocks. It mainly focuses on the potential of boronic acid derivatization and its activities in agrochemicals. Additionally, it covers the applications of boron-containing building blocks in pharmaceuticals, including their action mechanisms. |
| format | Article |
| id | doaj-art-96a80d6bd324446ba6e0d7e46d9b2124 |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-96a80d6bd324446ba6e0d7e46d9b21242025-08-20T03:56:46ZengMDPI AGMolecules1420-30492025-07-013014301810.3390/molecules30143018Potential of Boronic Acid Derivatization and Activity in Agrochemical DiscoveryLiangshuo Ji0Jianxin Wu1Yachen Zuo2Wenqiang Gao3Jiyao Feng4Zhenhua Zhang5College of Science, China Agricultural University, Beijing 100193, ChinaCollege of Science, China Agricultural University, Beijing 100193, ChinaCollege of Science, China Agricultural University, Beijing 100193, ChinaCollege of Plant Protection, China Agricultural University, Beijing 100193, ChinaCollege of Plant Protection, China Agricultural University, Beijing 100193, ChinaCollege of Science, China Agricultural University, Beijing 100193, ChinaSince the approval of Bortezomib (Velcade<sup>®</sup>) by the U.S. Food and Drug Administration (FDA) in 2003, boron-containing drugs have successfully entered the global market, spanning therapeutic areas such as anticancer, antibacterial, and antifungal agents. Meanwhile, boron is an essential trace element for plant growth, and boronic acid has been widely used as plant resistance inducers and growth promoters. In 2024, the Fungicide Resistance Action Committee (FRAC) introduced benzoxaboroles as a new category of fungicides, which fully demonstrates the significant application potential of boron-containing compounds (BCCs) in the field of agricultural fungicides. Recently, studies on BCCs in agriculture have emerged continuously. Compared with the systematic reviews in the pharmaceutical field, those focusing on BCCs in agriculture remain absent. This review systematically collates BCCs with reported biological activities from the literature over the past 20 years, from the perspective of boron-containing building blocks. It mainly focuses on the potential of boronic acid derivatization and its activities in agrochemicals. Additionally, it covers the applications of boron-containing building blocks in pharmaceuticals, including their action mechanisms.https://www.mdpi.com/1420-3049/30/14/3018boron-containing compoundsagrochemicalenvironmental stabilityenvironmental safety |
| spellingShingle | Liangshuo Ji Jianxin Wu Yachen Zuo Wenqiang Gao Jiyao Feng Zhenhua Zhang Potential of Boronic Acid Derivatization and Activity in Agrochemical Discovery Molecules boron-containing compounds agrochemical environmental stability environmental safety |
| title | Potential of Boronic Acid Derivatization and Activity in Agrochemical Discovery |
| title_full | Potential of Boronic Acid Derivatization and Activity in Agrochemical Discovery |
| title_fullStr | Potential of Boronic Acid Derivatization and Activity in Agrochemical Discovery |
| title_full_unstemmed | Potential of Boronic Acid Derivatization and Activity in Agrochemical Discovery |
| title_short | Potential of Boronic Acid Derivatization and Activity in Agrochemical Discovery |
| title_sort | potential of boronic acid derivatization and activity in agrochemical discovery |
| topic | boron-containing compounds agrochemical environmental stability environmental safety |
| url | https://www.mdpi.com/1420-3049/30/14/3018 |
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