CD103+ T Cells Eliminate Damaged Alveolar Epithelial Type II Cells Under Oxidative Stress to Prevent Lung Tumorigenesis

CD103+ T Cells Eliminate Damaged Alveolar Epithelial Type II Cells Under Oxidative Stress to Prevent Lung Tumorigenesis

Abstract The nexus between aging‐associated immune deteriorations and tumorigenesis of lung cancers remains elusive. In a mouse model with Med23 depletion in T cells (Med23 −/−), it is found a strong association between the decline of CD103+ T cells and spontaneous alveolar epithelial type II cell (...

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Bibliographic Details
Main Authors: Yu Xu, Haorui Luo, Jiahao Wang, Haifeng Liu, Luonan Chen, Hongbin Ji, Zimu Deng, Xiaolong Liu
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Advanced Science
Subjects:
AT2 cell
CD103+ T cell
lung adenocarcinoma
MED23
oxidative stress
tumorigenesis
Online Access:https://doi.org/10.1002/advs.202503557
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