Efficacy of Hyaluronic Acid in Radiation Proctitis: A Case Series
Gastrointestinal toxicities of radiation might develop after exposure, thus leading to conditions such as abdominal pain, rectal bleeding, diarrhea, anemia, and weight loss. The development of drugs to reduce mucosal damage progression has been a focus on managing radiation proctitis. Radiation proc...
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| Format: | Article |
| Language: | English |
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Interna Publishing
2024-07-01
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| Series: | Acta Medica Indonesiana |
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| Online Access: | https://actamedindones.org/index.php/ijim/article/view/2515 |
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| author | Marcellus Simadibrata Saskia Aziza Nursyirwan Rabbinu Rangga Pribadi Angelica Abigael Lidya Tanjaya |
| author_facet | Marcellus Simadibrata Saskia Aziza Nursyirwan Rabbinu Rangga Pribadi Angelica Abigael Lidya Tanjaya |
| author_sort | Marcellus Simadibrata |
| collection | DOAJ |
| description | Gastrointestinal toxicities of radiation might develop after exposure, thus leading to conditions such as abdominal pain, rectal bleeding, diarrhea, anemia, and weight loss. The development of drugs to reduce mucosal damage progression has been a focus on managing radiation proctitis. Radiation proctitis resulting from exposure to pelvic radiotherapies is effectively managed with topical administration on the anal mucosa. The clinical use of hyaluronic acid offers an innovative approach to managing radiation injury. Hyaluronic acid has multiple beneficial properties, such as regulating immune process to reduce inflammation and oxidative stress, supporting natural protective mechanism, promoting mucosa healing, and improving tissue hydration. Therefore, this case series introduces the idea that application of hyaluronic acid could potentially improve patients’ clinical conditions. |
| format | Article |
| id | doaj-art-96a1a2f4bf4f448e83fda923c56d4420 |
| institution | OA Journals |
| issn | 0125-9326 2338-2732 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | Acta Medica Indonesiana |
| spelling | doaj-art-96a1a2f4bf4f448e83fda923c56d44202025-08-20T02:12:11ZengInterna PublishingActa Medica Indonesiana0125-93262338-27322024-07-01563683Efficacy of Hyaluronic Acid in Radiation Proctitis: A Case SeriesMarcellus Simadibrata0Saskia Aziza Nursyirwan1Rabbinu Rangga Pribadi2Angelica Abigael3Lidya Tanjaya4Division of Gastroenterology, Pancreatobiliary, and Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General National Hospital, Jakarta, Indonesia.Division of Gastroenterology, Pancreatobiliary, and Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General National Hospital, Jakarta, Indonesia.Division of Gastroenterology, Pancreatobiliary, and Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General National Hospital, Jakarta, Indonesia.Division of Gastroenterology, Pancreatobiliary, and Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General National Hospital, Jakarta, Indonesia.Division of Gastroenterology, Pancreatobiliary, and Digestive Endoscopy, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General National Hospital, Jakarta, Indonesia.Gastrointestinal toxicities of radiation might develop after exposure, thus leading to conditions such as abdominal pain, rectal bleeding, diarrhea, anemia, and weight loss. The development of drugs to reduce mucosal damage progression has been a focus on managing radiation proctitis. Radiation proctitis resulting from exposure to pelvic radiotherapies is effectively managed with topical administration on the anal mucosa. The clinical use of hyaluronic acid offers an innovative approach to managing radiation injury. Hyaluronic acid has multiple beneficial properties, such as regulating immune process to reduce inflammation and oxidative stress, supporting natural protective mechanism, promoting mucosa healing, and improving tissue hydration. Therefore, this case series introduces the idea that application of hyaluronic acid could potentially improve patients’ clinical conditions.https://actamedindones.org/index.php/ijim/article/view/2515radiation proctitishyaluronic acidenema |
| spellingShingle | Marcellus Simadibrata Saskia Aziza Nursyirwan Rabbinu Rangga Pribadi Angelica Abigael Lidya Tanjaya Efficacy of Hyaluronic Acid in Radiation Proctitis: A Case Series Acta Medica Indonesiana radiation proctitis hyaluronic acid enema |
| title | Efficacy of Hyaluronic Acid in Radiation Proctitis: A Case Series |
| title_full | Efficacy of Hyaluronic Acid in Radiation Proctitis: A Case Series |
| title_fullStr | Efficacy of Hyaluronic Acid in Radiation Proctitis: A Case Series |
| title_full_unstemmed | Efficacy of Hyaluronic Acid in Radiation Proctitis: A Case Series |
| title_short | Efficacy of Hyaluronic Acid in Radiation Proctitis: A Case Series |
| title_sort | efficacy of hyaluronic acid in radiation proctitis a case series |
| topic | radiation proctitis hyaluronic acid enema |
| url | https://actamedindones.org/index.php/ijim/article/view/2515 |
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