Prenatal exposure to essential metals and blood pressure at preschool age: A birth cohort study
Aims: To investigate the association between prenatal exposure to essential metals and the offspring blood pressure (BP) at preschool age. Materials and methods: Data from a birth cohort study including 1113 mother-child pairs were analyzed. The associations between individual prenatal essential ele...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325002854 |
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| author | Caifang Xu Shiwei Jiang Hualin Wang Bowen Du Qianchuo Wang Zhuoyan Li Zhikang Xu Zhi Wang Junxia Liu Xi Zhang Kun Sun Jian Wang |
| author_facet | Caifang Xu Shiwei Jiang Hualin Wang Bowen Du Qianchuo Wang Zhuoyan Li Zhikang Xu Zhi Wang Junxia Liu Xi Zhang Kun Sun Jian Wang |
| author_sort | Caifang Xu |
| collection | DOAJ |
| description | Aims: To investigate the association between prenatal exposure to essential metals and the offspring blood pressure (BP) at preschool age. Materials and methods: Data from a birth cohort study including 1113 mother-child pairs were analyzed. The associations between individual prenatal essential elements and offspring BP were analyzed using generalized linear regression models. Bayesian Kernel Machine Regression (BKMR) and weighted quantile sum regression (WQS), were employed to examine the combined effects of prenatal metal exposures on offspring BP. The associations between essential metals and high blood pressure (HBP) of offspring were appraised using logistic regression model. Results: In the single-metal models, we found that maternal magnesium (Mg) concentrations were negatively associated with the offspring BP. The results of BKMR and WQS also identified a negative association between maternal essential metals mixtures and offspring BP. Logistic regression showed that compared to the highest quartiles of maternal Mg, the odds ratio (OR) for HBP in the lowest quartiles was 4.27 (95 % CI: 1.84–9.93). No significant associations were observed for other essential metals (all P value > 0.05). Additionally, no significant association was found between umbilical cord blood metal concentrations and offspring BP. Conclusions: Maternal essential metals mixtures, rather than those in umbilical cord blood, were negatively associated with offspring BP. Besides, lower maternal Mg levels were linked to a higher prevalence of HBP in offspring. Our findings provide significant evidence for exploring the effects of maternal essential metal elements on offspring BP. |
| format | Article |
| id | doaj-art-96a16333ae1f435fb4b7cde0990c3ef6 |
| institution | DOAJ |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-96a16333ae1f435fb4b7cde0990c3ef62025-08-20T02:57:33ZengElsevierEcotoxicology and Environmental Safety0147-65132025-03-0129211794910.1016/j.ecoenv.2025.117949Prenatal exposure to essential metals and blood pressure at preschool age: A birth cohort studyCaifang Xu0Shiwei Jiang1Hualin Wang2Bowen Du3Qianchuo Wang4Zhuoyan Li5Zhikang Xu6Zhi Wang7Junxia Liu8Xi Zhang9Kun Sun10Jian Wang11Department of Pediatric Cardiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Institute for Developmental and Regenerative Cardiovascular Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Pediatric Cardiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Pediatric Cardiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Pediatric Cardiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Pediatric Cardiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Pediatric Cardiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Pediatric Cardiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Institute for Developmental and Regenerative Cardiovascular Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Pediatric Cardiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Institute for Developmental and Regenerative Cardiovascular Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaMinistry of Education and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaClinical Research Unit, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Pediatric Cardiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Institute for Developmental and Regenerative Cardiovascular Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Correspondence to: Department of Pediatric Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, 1655 Kongjiang Rd, Shanghai 200092, China.Department of Pediatric Cardiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Institute for Developmental and Regenerative Cardiovascular Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Correspondence to: Department of Pediatric Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, 1655 Kongjiang Rd, Shanghai 200092, China.Aims: To investigate the association between prenatal exposure to essential metals and the offspring blood pressure (BP) at preschool age. Materials and methods: Data from a birth cohort study including 1113 mother-child pairs were analyzed. The associations between individual prenatal essential elements and offspring BP were analyzed using generalized linear regression models. Bayesian Kernel Machine Regression (BKMR) and weighted quantile sum regression (WQS), were employed to examine the combined effects of prenatal metal exposures on offspring BP. The associations between essential metals and high blood pressure (HBP) of offspring were appraised using logistic regression model. Results: In the single-metal models, we found that maternal magnesium (Mg) concentrations were negatively associated with the offspring BP. The results of BKMR and WQS also identified a negative association between maternal essential metals mixtures and offspring BP. Logistic regression showed that compared to the highest quartiles of maternal Mg, the odds ratio (OR) for HBP in the lowest quartiles was 4.27 (95 % CI: 1.84–9.93). No significant associations were observed for other essential metals (all P value > 0.05). Additionally, no significant association was found between umbilical cord blood metal concentrations and offspring BP. Conclusions: Maternal essential metals mixtures, rather than those in umbilical cord blood, were negatively associated with offspring BP. Besides, lower maternal Mg levels were linked to a higher prevalence of HBP in offspring. Our findings provide significant evidence for exploring the effects of maternal essential metal elements on offspring BP.http://www.sciencedirect.com/science/article/pii/S0147651325002854Prenatal exposeEssential metalsBlood pressureChildhood high blood pressure |
| spellingShingle | Caifang Xu Shiwei Jiang Hualin Wang Bowen Du Qianchuo Wang Zhuoyan Li Zhikang Xu Zhi Wang Junxia Liu Xi Zhang Kun Sun Jian Wang Prenatal exposure to essential metals and blood pressure at preschool age: A birth cohort study Ecotoxicology and Environmental Safety Prenatal expose Essential metals Blood pressure Childhood high blood pressure |
| title | Prenatal exposure to essential metals and blood pressure at preschool age: A birth cohort study |
| title_full | Prenatal exposure to essential metals and blood pressure at preschool age: A birth cohort study |
| title_fullStr | Prenatal exposure to essential metals and blood pressure at preschool age: A birth cohort study |
| title_full_unstemmed | Prenatal exposure to essential metals and blood pressure at preschool age: A birth cohort study |
| title_short | Prenatal exposure to essential metals and blood pressure at preschool age: A birth cohort study |
| title_sort | prenatal exposure to essential metals and blood pressure at preschool age a birth cohort study |
| topic | Prenatal expose Essential metals Blood pressure Childhood high blood pressure |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325002854 |
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