A dual-targeting strategy to inhibit colorectal cancer liver metastasis via tumor cell ferroptosis and cancer-associated fibroblast reprogramming

A dual-targeting strategy to inhibit colorectal cancer liver metastasis via tumor cell ferroptosis and cancer-associated fibroblast reprogramming

Colorectal cancer (CRC) remains a leading cause of cancer‐related mortality, with liver metastasis posing a significant therapeutic challenge. Within the “seed and soil” paradigm, disrupting both tumor cells and their supportive microenvironment is essential to suppress disease progression. Here, we...

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Bibliographic Details
Main Authors: Ziying Wu, Xiewei Lin, Yao Ying, Gaowei Fan, Junyao Shi, Xiaoqing Zheng, Ben Hu, Hungchen Che, Huiyang Chen, Weilong Yang, Xindi Fan, Ke Mo, Junming Wu, Zhien Lan, Zhiqiang Yu, Shengtao Wang, Chunhui Cui
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-10-01
Series:Bioactive Materials
Subjects:
Colorectal cancer liver metastasis
Ferroptosis
Cancer-associated fibroblasts
Tumor microenvironment
Dual-targeted nanosystem
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X25002191
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