Evaluation of the Potential Protective Role of Galangin Associated with Gold Nanoparticles in the Histological and Functional Structure of Testes of Adult Male Albino Mice Administrated with Carbon Tetrachloride
Galangin (Gal) is a natural flavonoid sourced from the roots of the plant Albina Kalanga. It possesses a variety of pharmacological activities, such as antioxidant, anticancer, and anti-inflammatory. The current study aims to enhance the efficacy of galangin through the use of gold nanoparticles as...
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University of Baghdad, College of Science for Women
2024-08-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/9086 |
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| author | Bassem Sultan Abeed Hanady Salim Al-Shmgani |
| author_facet | Bassem Sultan Abeed Hanady Salim Al-Shmgani |
| author_sort | Bassem Sultan Abeed |
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Galangin (Gal) is a natural flavonoid sourced from the roots of the plant Albina Kalanga. It possesses a variety of pharmacological activities, such as antioxidant, anticancer, and anti-inflammatory. The current study aims to enhance the efficacy of galangin through the use of gold nanoparticles as a drug delivery system against CCl4-induced toxicity in the testicular tissue of male albino mice. Forty-two albino mice were divided into seven groups (6 mice/group), treatment with carbon tetrachloride solution for two weeks by intraperitoneal injection, (1 ml/kg) once a week for all groups except the control group, after which a group was injected with gold nanoparticles and two groups were injected with galangin in two concentrations, and two groups were injected with AuNPs + Gal conjugation solution with two concentrations. The animals' bodies were weighed and blood samples were obtained for testosterone hormone analysis and testicles for the purpose of weighing and histological study at the end of the experiments. The study showed that the testicular tissue of mice treated with CCl4 had a different pathology compared to the control group, the testosterone hormone levels in the CCl4 group were significantly higher than those of the control group. Results from the AuNPs+Gal group showed a significant reduction in the effects of CCl4 toxicity on mice testicles, with testosterone levels are returning to normal and histological testicle structures improving, the ratio of testicle weights to animal body weight in the group injected with AuNPs was significantly higher than that of the control and CCl4 groups. In conclusion, the results revealed that galangin combined with gold nanoparticles could effectively reduced the histological and functional tissue damages caused by CCl4, presenting a promising natural solution that needs to be further developed
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| format | Article |
| id | doaj-art-9696fcbb19f14b7c94d50b006bf4c5a9 |
| institution | Kabale University |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | University of Baghdad, College of Science for Women |
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| series | مجلة بغداد للعلوم |
| spelling | doaj-art-9696fcbb19f14b7c94d50b006bf4c5a92025-08-20T03:57:04ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862024-08-0121810.21123/bsj.2024.9086Evaluation of the Potential Protective Role of Galangin Associated with Gold Nanoparticles in the Histological and Functional Structure of Testes of Adult Male Albino Mice Administrated with Carbon TetrachlorideBassem Sultan Abeed0https://orcid.org/0009-0001-9092-7760Hanady Salim Al-Shmgani1https://orcid.org/0000-0002-9108-4603Department of Biology, College of Education for Pure Sciences/Ibn Al-Haitham, University of Baghdad, Baghdad, Iraq.Department of Biology, College of Education for Pure Sciences/Ibn Al-Haitham, University of Baghdad, Baghdad, Iraq. Galangin (Gal) is a natural flavonoid sourced from the roots of the plant Albina Kalanga. It possesses a variety of pharmacological activities, such as antioxidant, anticancer, and anti-inflammatory. The current study aims to enhance the efficacy of galangin through the use of gold nanoparticles as a drug delivery system against CCl4-induced toxicity in the testicular tissue of male albino mice. Forty-two albino mice were divided into seven groups (6 mice/group), treatment with carbon tetrachloride solution for two weeks by intraperitoneal injection, (1 ml/kg) once a week for all groups except the control group, after which a group was injected with gold nanoparticles and two groups were injected with galangin in two concentrations, and two groups were injected with AuNPs + Gal conjugation solution with two concentrations. The animals' bodies were weighed and blood samples were obtained for testosterone hormone analysis and testicles for the purpose of weighing and histological study at the end of the experiments. The study showed that the testicular tissue of mice treated with CCl4 had a different pathology compared to the control group, the testosterone hormone levels in the CCl4 group were significantly higher than those of the control group. Results from the AuNPs+Gal group showed a significant reduction in the effects of CCl4 toxicity on mice testicles, with testosterone levels are returning to normal and histological testicle structures improving, the ratio of testicle weights to animal body weight in the group injected with AuNPs was significantly higher than that of the control and CCl4 groups. In conclusion, the results revealed that galangin combined with gold nanoparticles could effectively reduced the histological and functional tissue damages caused by CCl4, presenting a promising natural solution that needs to be further developed https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/9086albino mice, CCl4, Galangin, Gold nanoparticles, testicular tissue |
| spellingShingle | Bassem Sultan Abeed Hanady Salim Al-Shmgani Evaluation of the Potential Protective Role of Galangin Associated with Gold Nanoparticles in the Histological and Functional Structure of Testes of Adult Male Albino Mice Administrated with Carbon Tetrachloride مجلة بغداد للعلوم albino mice, CCl4, Galangin, Gold nanoparticles, testicular tissue |
| title | Evaluation of the Potential Protective Role of Galangin Associated with Gold Nanoparticles in the Histological and Functional Structure of Testes of Adult Male Albino Mice Administrated with Carbon Tetrachloride |
| title_full | Evaluation of the Potential Protective Role of Galangin Associated with Gold Nanoparticles in the Histological and Functional Structure of Testes of Adult Male Albino Mice Administrated with Carbon Tetrachloride |
| title_fullStr | Evaluation of the Potential Protective Role of Galangin Associated with Gold Nanoparticles in the Histological and Functional Structure of Testes of Adult Male Albino Mice Administrated with Carbon Tetrachloride |
| title_full_unstemmed | Evaluation of the Potential Protective Role of Galangin Associated with Gold Nanoparticles in the Histological and Functional Structure of Testes of Adult Male Albino Mice Administrated with Carbon Tetrachloride |
| title_short | Evaluation of the Potential Protective Role of Galangin Associated with Gold Nanoparticles in the Histological and Functional Structure of Testes of Adult Male Albino Mice Administrated with Carbon Tetrachloride |
| title_sort | evaluation of the potential protective role of galangin associated with gold nanoparticles in the histological and functional structure of testes of adult male albino mice administrated with carbon tetrachloride |
| topic | albino mice, CCl4, Galangin, Gold nanoparticles, testicular tissue |
| url | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/9086 |
| work_keys_str_mv | AT bassemsultanabeed evaluationofthepotentialprotectiveroleofgalanginassociatedwithgoldnanoparticlesinthehistologicalandfunctionalstructureoftestesofadultmalealbinomiceadministratedwithcarbontetrachloride AT hanadysalimalshmgani evaluationofthepotentialprotectiveroleofgalanginassociatedwithgoldnanoparticlesinthehistologicalandfunctionalstructureoftestesofadultmalealbinomiceadministratedwithcarbontetrachloride |