The Macrophage–Fibroblast Dipole in the Context of Cardiac Repair and Fibrosis
Stromal and immune cells and their interactions have gained the attention of cardiology researchers and clinicians in recent years as their contribution in cardiac repair is increasingly recognized. The repair process in the heart is a particularly critical constellation of complex molecular and cel...
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MDPI AG
2024-11-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/14/11/1403 |
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| author | Stelios Psarras |
| author_facet | Stelios Psarras |
| author_sort | Stelios Psarras |
| collection | DOAJ |
| description | Stromal and immune cells and their interactions have gained the attention of cardiology researchers and clinicians in recent years as their contribution in cardiac repair is increasingly recognized. The repair process in the heart is a particularly critical constellation of complex molecular and cellular events and interactions that characteristically fail to ensure adequate recovery following injury, insult, or exposure to stress conditions in this regeneration-hostile organ. The tremendous consequence of this pronounced inability to maintain homeostatic states is being translated in numerous ways promoting progress into heart failure, a deadly, irreversible condition requiring organ transplantation. Fibrosis is in fact a repair response eventually promoting cardiac dysfunction and cardiac fibroblasts are the major cellular players in this process, overproducing collagens and other extracellular matrix components when activated. On the other hand, macrophages may differentially affect fibroblasts and cardiac repair depending on their status and subsets. The opposite interaction is also probable. We discuss here the multifaceted aspects and crosstalk of this cell dipole and the opportunities it may offer for beneficial manipulation approaches that will hopefully lead to progress in heart disease interventions. |
| format | Article |
| id | doaj-art-969388b64fba44e7a899e0160036d3ac |
| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-969388b64fba44e7a899e0160036d3ac2024-11-26T17:54:09ZengMDPI AGBiomolecules2218-273X2024-11-011411140310.3390/biom14111403The Macrophage–Fibroblast Dipole in the Context of Cardiac Repair and FibrosisStelios Psarras0Center of Basic Research, Biomedical Research Foundation of the Academy of Athens, Soranou Efesiou 4, 115 27 Athens, GreeceStromal and immune cells and their interactions have gained the attention of cardiology researchers and clinicians in recent years as their contribution in cardiac repair is increasingly recognized. The repair process in the heart is a particularly critical constellation of complex molecular and cellular events and interactions that characteristically fail to ensure adequate recovery following injury, insult, or exposure to stress conditions in this regeneration-hostile organ. The tremendous consequence of this pronounced inability to maintain homeostatic states is being translated in numerous ways promoting progress into heart failure, a deadly, irreversible condition requiring organ transplantation. Fibrosis is in fact a repair response eventually promoting cardiac dysfunction and cardiac fibroblasts are the major cellular players in this process, overproducing collagens and other extracellular matrix components when activated. On the other hand, macrophages may differentially affect fibroblasts and cardiac repair depending on their status and subsets. The opposite interaction is also probable. We discuss here the multifaceted aspects and crosstalk of this cell dipole and the opportunities it may offer for beneficial manipulation approaches that will hopefully lead to progress in heart disease interventions.https://www.mdpi.com/2218-273X/14/11/1403cardiac fibrosistissue repairmacrophagefibroblastcellular interactions |
| spellingShingle | Stelios Psarras The Macrophage–Fibroblast Dipole in the Context of Cardiac Repair and Fibrosis Biomolecules cardiac fibrosis tissue repair macrophage fibroblast cellular interactions |
| title | The Macrophage–Fibroblast Dipole in the Context of Cardiac Repair and Fibrosis |
| title_full | The Macrophage–Fibroblast Dipole in the Context of Cardiac Repair and Fibrosis |
| title_fullStr | The Macrophage–Fibroblast Dipole in the Context of Cardiac Repair and Fibrosis |
| title_full_unstemmed | The Macrophage–Fibroblast Dipole in the Context of Cardiac Repair and Fibrosis |
| title_short | The Macrophage–Fibroblast Dipole in the Context of Cardiac Repair and Fibrosis |
| title_sort | macrophage fibroblast dipole in the context of cardiac repair and fibrosis |
| topic | cardiac fibrosis tissue repair macrophage fibroblast cellular interactions |
| url | https://www.mdpi.com/2218-273X/14/11/1403 |
| work_keys_str_mv | AT steliospsarras themacrophagefibroblastdipoleinthecontextofcardiacrepairandfibrosis AT steliospsarras macrophagefibroblastdipoleinthecontextofcardiacrepairandfibrosis |