Copper strontium phosphate glasses with high antimicrobial efficacy
Abstract The emergence of antibiotic-resistant strains caused by the extensive use of antibiotics in the world requires a preventive approach to stop the infection spread, especially in a hospital setting. So, there is a growing demand for materials that can inhibit bacteria growth or have bacterici...
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Nature Portfolio
2025-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-88781-z |
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| author | Roman Golovchak Bohdan Mahlovanyi Yaroslav Shpotyuk Malgorzata Kus-Liskiewicz Julia Kozianska Renata Zadrag-Tecza Grzegorz Zagula Malgorzata Trzyna-Sowa Andriy Kovalskiy Agnieszka Gala-Bladzinska Jozef Cebulski |
| author_facet | Roman Golovchak Bohdan Mahlovanyi Yaroslav Shpotyuk Malgorzata Kus-Liskiewicz Julia Kozianska Renata Zadrag-Tecza Grzegorz Zagula Malgorzata Trzyna-Sowa Andriy Kovalskiy Agnieszka Gala-Bladzinska Jozef Cebulski |
| author_sort | Roman Golovchak |
| collection | DOAJ |
| description | Abstract The emergence of antibiotic-resistant strains caused by the extensive use of antibiotics in the world requires a preventive approach to stop the infection spread, especially in a hospital setting. So, there is a growing demand for materials that can inhibit bacteria growth or have bactericidal effects. In this paper, an inexpensive and durable Cu-containing strontium-modified phosphate glass with a considerable antimicrobial effect is proposed. The basic physical properties of the material are studied, and its antimicrobial effect is evaluated on Staphylococcus aureus bacteria, known to be the most common problem in hospital environments because of healthcare-associated infections. The glass powders demonstrate strong antibacterial efficacy with a concentration of only a few mg/mL, sufficient to eradicate the entire bacterial colonies within 24 h. Bulk surfaces of these glasses inhibit bacterial growth and release low, non-toxic levels of their constituent elements into simulated body fluid. On the basis of the obtained results, it is shown that the proposed glass can be used as a structural material for various medical equipment and/or components of antimicrobial coating/paint not only in medicine but also for high touch point articles in public places like schools, gyms, public offices and similar. |
| format | Article |
| id | doaj-art-9690306a5e3e4f159cf34d853676c85e |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-9690306a5e3e4f159cf34d853676c85e2025-02-09T12:32:35ZengNature PortfolioScientific Reports2045-23222025-02-0115111310.1038/s41598-025-88781-zCopper strontium phosphate glasses with high antimicrobial efficacyRoman Golovchak0Bohdan Mahlovanyi1Yaroslav Shpotyuk2Malgorzata Kus-Liskiewicz3Julia Kozianska4Renata Zadrag-Tecza5Grzegorz Zagula6Malgorzata Trzyna-Sowa7Andriy Kovalskiy8Agnieszka Gala-Bladzinska9Jozef Cebulski10Department of Physics, Engineering and Astronomy, Austin Peay State UniversityInstitute of Physics, Rzeszow UniversityInstitute of Physics, Rzeszow UniversityInstitute of Biotechnology, College of Natural Sciences, Rzeszow UniversityInstitute of Biotechnology, College of Natural Sciences, Rzeszow UniversityInstitute of Biology, College of Natural Sciences, Rzeszow UniversityInstitute of Food Technology and Nutrition, College of Natural Sciences, Rzeszow UniversityInstitute of Materials Engineering, Center for Microelectronics and Nanotechnology, Rzeszow UniversityDepartment of Physics, Engineering and Astronomy, Austin Peay State UniversityInstitute of Medical Sciences, Medical College of Rzeszow UniversityInstitute of Physics, Rzeszow UniversityAbstract The emergence of antibiotic-resistant strains caused by the extensive use of antibiotics in the world requires a preventive approach to stop the infection spread, especially in a hospital setting. So, there is a growing demand for materials that can inhibit bacteria growth or have bactericidal effects. In this paper, an inexpensive and durable Cu-containing strontium-modified phosphate glass with a considerable antimicrobial effect is proposed. The basic physical properties of the material are studied, and its antimicrobial effect is evaluated on Staphylococcus aureus bacteria, known to be the most common problem in hospital environments because of healthcare-associated infections. The glass powders demonstrate strong antibacterial efficacy with a concentration of only a few mg/mL, sufficient to eradicate the entire bacterial colonies within 24 h. Bulk surfaces of these glasses inhibit bacterial growth and release low, non-toxic levels of their constituent elements into simulated body fluid. On the basis of the obtained results, it is shown that the proposed glass can be used as a structural material for various medical equipment and/or components of antimicrobial coating/paint not only in medicine but also for high touch point articles in public places like schools, gyms, public offices and similar.https://doi.org/10.1038/s41598-025-88781-z |
| spellingShingle | Roman Golovchak Bohdan Mahlovanyi Yaroslav Shpotyuk Malgorzata Kus-Liskiewicz Julia Kozianska Renata Zadrag-Tecza Grzegorz Zagula Malgorzata Trzyna-Sowa Andriy Kovalskiy Agnieszka Gala-Bladzinska Jozef Cebulski Copper strontium phosphate glasses with high antimicrobial efficacy Scientific Reports |
| title | Copper strontium phosphate glasses with high antimicrobial efficacy |
| title_full | Copper strontium phosphate glasses with high antimicrobial efficacy |
| title_fullStr | Copper strontium phosphate glasses with high antimicrobial efficacy |
| title_full_unstemmed | Copper strontium phosphate glasses with high antimicrobial efficacy |
| title_short | Copper strontium phosphate glasses with high antimicrobial efficacy |
| title_sort | copper strontium phosphate glasses with high antimicrobial efficacy |
| url | https://doi.org/10.1038/s41598-025-88781-z |
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