The relationship between SIRT1 and inflammation: a systematic review and meta-analysis
Recent studies underscore the anti-inflammatory role of SIRT1; however, its levels during inflammatory states remain ambiguous. We synthesized relevant studies up to 20 March 2024 to evaluate the relationship between SIRT1 and inflammation, using data from three major databases. Employing a random-e...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1465849/full |
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| author | Haiyang Sun Dong Li Chaojie Wei Liping Liu Zhuoyuan Xin Hang Gao Rong Gao |
| author_facet | Haiyang Sun Dong Li Chaojie Wei Liping Liu Zhuoyuan Xin Hang Gao Rong Gao |
| author_sort | Haiyang Sun |
| collection | DOAJ |
| description | Recent studies underscore the anti-inflammatory role of SIRT1; however, its levels during inflammatory states remain ambiguous. We synthesized relevant studies up to 20 March 2024 to evaluate the relationship between SIRT1 and inflammation, using data from three major databases. Employing a random-effects model, we analyzed both cross-sectional and longitudinal studies, calculating weighted mean differences (WMDs) for pooled effect sizes. Subgroup and sensitivity analyses, along with a risk of bias assessment, were also conducted. We reviewed 13 publications, encompassing 21 datasets and 2,028 participants. The meta-analysis indicated higher SIRT1 levels in inflammatory groups compared to control groups pre-adjustment (WMD, 3.18 ng/ml; 95% CI 2.30, 4.06 ng/ml; P<0.001; I²= 99.7%) and post-adjustment (WMD, 0.88 ng/ml; 95% CI 0.14, 1.62 ng/ml; P<0.001; I²= 99.5%). Notably, middle-aged patients with inflammation exhibited lower SIRT1 levels (WMD, −0.85 ng/ml; 95% CI −1.47, −0.22 ng/ml; P= 0.008; I²= 95.4%), while groups characterized by East Asian descent, plasma studies, autoimmune conditions, and musculoskeletal disorders showed higher levels. The findings suggest that inflammation generally upregulates SIRT1, potentially elucidating its role in immunobiological processes. However, the significant heterogeneity observed, partly due to the cross-sectional nature of some data, limits insights into the duration of disease progression, which remains highly variable. |
| format | Article |
| id | doaj-art-968eb2f4547d465b8b5eebe23c039398 |
| institution | DOAJ |
| issn | 1664-3224 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Immunology |
| spelling | doaj-art-968eb2f4547d465b8b5eebe23c0393982025-08-20T02:48:45ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-11-011510.3389/fimmu.2024.14658491465849The relationship between SIRT1 and inflammation: a systematic review and meta-analysisHaiyang Sun0Dong Li1Chaojie Wei2Liping Liu3Zhuoyuan Xin4Hang Gao5Rong Gao6Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun, ChinaDepartment of Immunology, College of Basic Medical Sciences, Jilin University, Changchun, ChinaDepartment of Immunology, College of Basic Medical Sciences, Jilin University, Changchun, ChinaDepartment of Immunology, College of Basic Medical Sciences, Jilin University, Changchun, ChinaKey Laboratory of Zoonosis Research, Ministry of Education, College of Basic Medical Science, Jilin University, Changchun, ChinaDepartment of Bone and Joint Surgery, Orthopaedic Surgery Center, The First Hospital of Jilin University, Changchun, ChinaDepartment of Respiratory and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, ChinaRecent studies underscore the anti-inflammatory role of SIRT1; however, its levels during inflammatory states remain ambiguous. We synthesized relevant studies up to 20 March 2024 to evaluate the relationship between SIRT1 and inflammation, using data from three major databases. Employing a random-effects model, we analyzed both cross-sectional and longitudinal studies, calculating weighted mean differences (WMDs) for pooled effect sizes. Subgroup and sensitivity analyses, along with a risk of bias assessment, were also conducted. We reviewed 13 publications, encompassing 21 datasets and 2,028 participants. The meta-analysis indicated higher SIRT1 levels in inflammatory groups compared to control groups pre-adjustment (WMD, 3.18 ng/ml; 95% CI 2.30, 4.06 ng/ml; P<0.001; I²= 99.7%) and post-adjustment (WMD, 0.88 ng/ml; 95% CI 0.14, 1.62 ng/ml; P<0.001; I²= 99.5%). Notably, middle-aged patients with inflammation exhibited lower SIRT1 levels (WMD, −0.85 ng/ml; 95% CI −1.47, −0.22 ng/ml; P= 0.008; I²= 95.4%), while groups characterized by East Asian descent, plasma studies, autoimmune conditions, and musculoskeletal disorders showed higher levels. The findings suggest that inflammation generally upregulates SIRT1, potentially elucidating its role in immunobiological processes. However, the significant heterogeneity observed, partly due to the cross-sectional nature of some data, limits insights into the duration of disease progression, which remains highly variable.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1465849/fullSIRT1inflammationmeta-analysisNF-κBsystematic review |
| spellingShingle | Haiyang Sun Dong Li Chaojie Wei Liping Liu Zhuoyuan Xin Hang Gao Rong Gao The relationship between SIRT1 and inflammation: a systematic review and meta-analysis Frontiers in Immunology SIRT1 inflammation meta-analysis NF-κB systematic review |
| title | The relationship between SIRT1 and inflammation: a systematic review and meta-analysis |
| title_full | The relationship between SIRT1 and inflammation: a systematic review and meta-analysis |
| title_fullStr | The relationship between SIRT1 and inflammation: a systematic review and meta-analysis |
| title_full_unstemmed | The relationship between SIRT1 and inflammation: a systematic review and meta-analysis |
| title_short | The relationship between SIRT1 and inflammation: a systematic review and meta-analysis |
| title_sort | relationship between sirt1 and inflammation a systematic review and meta analysis |
| topic | SIRT1 inflammation meta-analysis NF-κB systematic review |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1465849/full |
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