Unraveling atomic complexity from frozen samples
Cryo-electron microscopy (cryo-EM) is a significant driver of recent advances in structural biology. Cryo-EM is comprised of several distinct and complementary methods, which include single particle analysis, cryo-electron tomography, and microcrystal electron diffraction. In this Perspective, we wi...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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AIP Publishing LLC and ACA
2025-03-01
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| Series: | Structural Dynamics |
| Online Access: | http://dx.doi.org/10.1063/4.0000303 |
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| author | Yasmeen N. Ruma Brent L. Nannenga Tamir Gonen |
| author_facet | Yasmeen N. Ruma Brent L. Nannenga Tamir Gonen |
| author_sort | Yasmeen N. Ruma |
| collection | DOAJ |
| description | Cryo-electron microscopy (cryo-EM) is a significant driver of recent advances in structural biology. Cryo-EM is comprised of several distinct and complementary methods, which include single particle analysis, cryo-electron tomography, and microcrystal electron diffraction. In this Perspective, we will briefly discuss the different branches of cryo-EM in structural biology and the current challenges in these areas. |
| format | Article |
| id | doaj-art-968c9eeafbaf442c8da15016d7de1e35 |
| institution | OA Journals |
| issn | 2329-7778 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | AIP Publishing LLC and ACA |
| record_format | Article |
| series | Structural Dynamics |
| spelling | doaj-art-968c9eeafbaf442c8da15016d7de1e352025-08-20T01:48:15ZengAIP Publishing LLC and ACAStructural Dynamics2329-77782025-03-01122020901020901-810.1063/4.0000303Unraveling atomic complexity from frozen samplesYasmeen N. Ruma0Brent L. Nannenga1Tamir Gonen2Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, California 90095, USAChemical Engineering, School for Engineering of Matter, Transport and Energy, Arizona State University, Tempe, Arizona 85287, USADepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, California 90095, USACryo-electron microscopy (cryo-EM) is a significant driver of recent advances in structural biology. Cryo-EM is comprised of several distinct and complementary methods, which include single particle analysis, cryo-electron tomography, and microcrystal electron diffraction. In this Perspective, we will briefly discuss the different branches of cryo-EM in structural biology and the current challenges in these areas.http://dx.doi.org/10.1063/4.0000303 |
| spellingShingle | Yasmeen N. Ruma Brent L. Nannenga Tamir Gonen Unraveling atomic complexity from frozen samples Structural Dynamics |
| title | Unraveling atomic complexity from frozen samples |
| title_full | Unraveling atomic complexity from frozen samples |
| title_fullStr | Unraveling atomic complexity from frozen samples |
| title_full_unstemmed | Unraveling atomic complexity from frozen samples |
| title_short | Unraveling atomic complexity from frozen samples |
| title_sort | unraveling atomic complexity from frozen samples |
| url | http://dx.doi.org/10.1063/4.0000303 |
| work_keys_str_mv | AT yasmeennruma unravelingatomiccomplexityfromfrozensamples AT brentlnannenga unravelingatomiccomplexityfromfrozensamples AT tamirgonen unravelingatomiccomplexityfromfrozensamples |