Comparative mechanistic study of green-synthesized silver-zinc oxide (Ag-ZnO) and iron–Zinc oxide (Fe-ZnO) bimetallic nanoparticles in antiglycation, antidiabetic, antioxidant, and anticancer activities
Bimetallic nanoparticles (BNPs) have gained immense attention for their diverse biological applications. This study aimed to biosynthesize and characterize Ag-ZnONPs and Fe-ZnONPs and compare their potential as therapeutic agents. The BNPs were synthesized using Mentha asiatica plant extract and cha...
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Taylor & Francis Group
2025-12-01
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| Series: | Journal of Taibah University for Science |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/16583655.2025.2515712 |
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| author | Sumaira Anjum Mubashra Inam Amar Yasser Jassim Iqra Attique Maryam Zahra Fayez Althobaiti Mohamed Mohamed Soliman Khalid S. Alotaibi Shatha B. Albattal Christophe Hano |
| author_facet | Sumaira Anjum Mubashra Inam Amar Yasser Jassim Iqra Attique Maryam Zahra Fayez Althobaiti Mohamed Mohamed Soliman Khalid S. Alotaibi Shatha B. Albattal Christophe Hano |
| author_sort | Sumaira Anjum |
| collection | DOAJ |
| description | Bimetallic nanoparticles (BNPs) have gained immense attention for their diverse biological applications. This study aimed to biosynthesize and characterize Ag-ZnONPs and Fe-ZnONPs and compare their potential as therapeutic agents. The BNPs were synthesized using Mentha asiatica plant extract and characterized using various techniques such as UV-visible spectroscopy, TEM, EDX spectroscopy, ATR-FTIR spectroscopy, PXRD, DLS, and zeta potential analyses. TEM, EDX, and XRD revealed the structural and morphological properties of crystalline Ag-ZnONPs and Fe-ZnONPs. FTIR analysis investigated the plant phytochemicals responsible for the stabilization and capping of BNPs. Ag-ZnONPs showed higher biocompatibility than Fe-ZnONPs. Fe-ZnONPs exhibited-significantly higher anticancer potential than Ag-ZnONPs as evident by Reactive Oxygen Species/ Nitric Oxide Synthase production, along with cell viability analysis, loss of mitochondrial-membrane potential, enhanced caspase-3 gene-expression, and intensified activity of Caspase-3/7. Collectively, our findings underscore the promising therapeutic-potential of BNPs in cancer treatment and diabetes, setting them as strong candidates for future biomedical applications. |
| format | Article |
| id | doaj-art-96853a2f7dc14accb1d83f36d5de69cc |
| institution | OA Journals |
| issn | 1658-3655 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Taibah University for Science |
| spelling | doaj-art-96853a2f7dc14accb1d83f36d5de69cc2025-08-20T02:32:26ZengTaylor & Francis GroupJournal of Taibah University for Science1658-36552025-12-0119110.1080/16583655.2025.2515712Comparative mechanistic study of green-synthesized silver-zinc oxide (Ag-ZnO) and iron–Zinc oxide (Fe-ZnO) bimetallic nanoparticles in antiglycation, antidiabetic, antioxidant, and anticancer activitiesSumaira Anjum0Mubashra Inam1Amar Yasser Jassim2Iqra Attique3Maryam Zahra4Fayez Althobaiti5Mohamed Mohamed Soliman6Khalid S. Alotaibi7Shatha B. Albattal8Christophe Hano9Department of Biotechnology, Kinnaird College for Women, Lahore, PakistanDepartment of Biotechnology, Kinnaird College for Women, Lahore, PakistanMarine Science Center, University of Basrah, Basrah, IraqDepartment of Biotechnology, Kinnaird College for Women, Lahore, PakistanDepartment of Biotechnology, Kinnaird College for Women, Lahore, PakistanDepartment of Biotechnology, College of Science, Taif University, Taif, Saudi ArabiaClinical Laboratory Sciences Department, Turabah University College, Taif University, Taif, Saudi ArabiaGeneral Science and English Language Department, College of Applied Sciences, AlMaarefa University, Riyadh, Saudi ArabiaGeneral Science and English Language Department, College of Applied Sciences, AlMaarefa University, Riyadh, Saudi ArabiaDepartment of Chemical Biology, Eure & Loir Campus, University of Orleans, FranceBimetallic nanoparticles (BNPs) have gained immense attention for their diverse biological applications. This study aimed to biosynthesize and characterize Ag-ZnONPs and Fe-ZnONPs and compare their potential as therapeutic agents. The BNPs were synthesized using Mentha asiatica plant extract and characterized using various techniques such as UV-visible spectroscopy, TEM, EDX spectroscopy, ATR-FTIR spectroscopy, PXRD, DLS, and zeta potential analyses. TEM, EDX, and XRD revealed the structural and morphological properties of crystalline Ag-ZnONPs and Fe-ZnONPs. FTIR analysis investigated the plant phytochemicals responsible for the stabilization and capping of BNPs. Ag-ZnONPs showed higher biocompatibility than Fe-ZnONPs. Fe-ZnONPs exhibited-significantly higher anticancer potential than Ag-ZnONPs as evident by Reactive Oxygen Species/ Nitric Oxide Synthase production, along with cell viability analysis, loss of mitochondrial-membrane potential, enhanced caspase-3 gene-expression, and intensified activity of Caspase-3/7. Collectively, our findings underscore the promising therapeutic-potential of BNPs in cancer treatment and diabetes, setting them as strong candidates for future biomedical applications.https://www.tandfonline.com/doi/10.1080/16583655.2025.2515712Mentha asiaticabimetallic nanoparticlessilver-zinc oxide and iron-zinc oxideanticancerantidiabetic and antiglycationantioxidant |
| spellingShingle | Sumaira Anjum Mubashra Inam Amar Yasser Jassim Iqra Attique Maryam Zahra Fayez Althobaiti Mohamed Mohamed Soliman Khalid S. Alotaibi Shatha B. Albattal Christophe Hano Comparative mechanistic study of green-synthesized silver-zinc oxide (Ag-ZnO) and iron–Zinc oxide (Fe-ZnO) bimetallic nanoparticles in antiglycation, antidiabetic, antioxidant, and anticancer activities Journal of Taibah University for Science Mentha asiatica bimetallic nanoparticles silver-zinc oxide and iron-zinc oxide anticancer antidiabetic and antiglycation antioxidant |
| title | Comparative mechanistic study of green-synthesized silver-zinc oxide (Ag-ZnO) and iron–Zinc oxide (Fe-ZnO) bimetallic nanoparticles in antiglycation, antidiabetic, antioxidant, and anticancer activities |
| title_full | Comparative mechanistic study of green-synthesized silver-zinc oxide (Ag-ZnO) and iron–Zinc oxide (Fe-ZnO) bimetallic nanoparticles in antiglycation, antidiabetic, antioxidant, and anticancer activities |
| title_fullStr | Comparative mechanistic study of green-synthesized silver-zinc oxide (Ag-ZnO) and iron–Zinc oxide (Fe-ZnO) bimetallic nanoparticles in antiglycation, antidiabetic, antioxidant, and anticancer activities |
| title_full_unstemmed | Comparative mechanistic study of green-synthesized silver-zinc oxide (Ag-ZnO) and iron–Zinc oxide (Fe-ZnO) bimetallic nanoparticles in antiglycation, antidiabetic, antioxidant, and anticancer activities |
| title_short | Comparative mechanistic study of green-synthesized silver-zinc oxide (Ag-ZnO) and iron–Zinc oxide (Fe-ZnO) bimetallic nanoparticles in antiglycation, antidiabetic, antioxidant, and anticancer activities |
| title_sort | comparative mechanistic study of green synthesized silver zinc oxide ag zno and iron zinc oxide fe zno bimetallic nanoparticles in antiglycation antidiabetic antioxidant and anticancer activities |
| topic | Mentha asiatica bimetallic nanoparticles silver-zinc oxide and iron-zinc oxide anticancer antidiabetic and antiglycation antioxidant |
| url | https://www.tandfonline.com/doi/10.1080/16583655.2025.2515712 |
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