Dimethyl α-ketoglutarate ameliorates cisplatin-induced acute kidney injury by modulating mitophagy through the PINK1/Parkin pathway

Dimethyl α-ketoglutarate ameliorates cisplatin-induced acute kidney injury by modulating mitophagy through the PINK1/Parkin pathway

Abstract Background Mitochondrial dysfunction and abnormal energy metabolism are key determinants of the progression of acute kidney injury (AKI). α-Ketoglutarate (AKG) is an intermediate metabolite of the tricarboxylic acid cycle and plays a crucial role in energy metabolism and amino acid synthesi...

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Bibliographic Details
Main Authors: Haijing Dou, Huihui Hao, Ruoyi Zhao, Hailun Li, Fangshu Wei, Yong Xu, Donghui Zheng, Juan Xie, Xiang Li
Format: Article
Language:English
Published: BMC 2025-08-01
Series:European Journal of Medical Research
Subjects:
Alpha-ketoglutarate
Mitophagy
Cisplatin
Acute kidney injury
Network pharmacology
Online Access:https://doi.org/10.1186/s40001-025-03010-7
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