Zuclopenthixol decanoate in pregnancy: Successful outcomes in two consecutive off springs of the same mother
Introduction. Almost all individual antipsychotics are classified into the intermediate pregnancy risk category as no or limited data exist about human pregnancy outcomes. We presented the case of zuclopenthixol decanoate using in two successive pregnancies of the same woman, which had not been p...
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2013-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2013/0042-84501300005J.pdf |
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| author | Janjić Vladimir Milovanović Dragan R. Ružić-Zecević Dejana Lončar Dragan Laban Olivera Stepanović Marija Varjačić Mirjana Obradović Slobodan Đukić-Dejanović Slavica Janković Slobodan |
| author_facet | Janjić Vladimir Milovanović Dragan R. Ružić-Zecević Dejana Lončar Dragan Laban Olivera Stepanović Marija Varjačić Mirjana Obradović Slobodan Đukić-Dejanović Slavica Janković Slobodan |
| author_sort | Janjić Vladimir |
| collection | DOAJ |
| description | Introduction. Almost all individual antipsychotics are classified into the intermediate pregnancy risk category as no or limited data exist about human pregnancy outcomes. We presented the case of zuclopenthixol decanoate using in two successive pregnancies of the same woman, which had not been published in the available peer-reviewed literature. Case report. A middle-age female subject who suffered from schizophrenia received zuclopenthixol decanoate injection during her two consecutive pregnancies. About four and a half months before diagnosis of the first pregnancy (~3.5 years after psychosis emergence), zuclopenthixol decanoate (400 mg every other week, im injection) was introduced to the treatment protocol (due to previous non-compliance with haloperidol and risperidone). A significant clinical improvement was achieved and the dose during pregnancy was reduced to 200 mg once monthly and maintained to date. In both pregnancies the women gave birth to healthy girls who have been developing normally until now, at their ages of 6 months and of 3.5 years. During pregnancy and after giving birth to children the mothers’ psychiatric status and her social functioning were significantly improved and are still stable. Close monitoring of the mother’s health, a multidisciplinary approach to both her treatment and the monitoring of pregnancies as well as the complete compliance with the prescribed drug protocol were likely to be crucial for the therapeutic success. Conclusion. A favorable outcome of the present case suggests that the zuclopenthixol decanoate is a rational therapeutic option for pregnant women suffering from psychosis when the expected benefit exceed the potential risk, but a definitive evidence for its safety requires large, controlled studies. [Projekat Ministarstva nauke Republike Srbije, br. 175014] |
| format | Article |
| id | doaj-art-966ea5b832794199ba79adcaa943d604 |
| institution | OA Journals |
| issn | 0042-8450 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-966ea5b832794199ba79adcaa943d6042025-08-20T01:58:19ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502013-01-0170552652910.2298/VSP120208005JZuclopenthixol decanoate in pregnancy: Successful outcomes in two consecutive off springs of the same motherJanjić VladimirMilovanović Dragan R.Ružić-Zecević DejanaLončar DraganLaban OliveraStepanović MarijaVarjačić MirjanaObradović SlobodanĐukić-Dejanović SlavicaJanković SlobodanIntroduction. Almost all individual antipsychotics are classified into the intermediate pregnancy risk category as no or limited data exist about human pregnancy outcomes. We presented the case of zuclopenthixol decanoate using in two successive pregnancies of the same woman, which had not been published in the available peer-reviewed literature. Case report. A middle-age female subject who suffered from schizophrenia received zuclopenthixol decanoate injection during her two consecutive pregnancies. About four and a half months before diagnosis of the first pregnancy (~3.5 years after psychosis emergence), zuclopenthixol decanoate (400 mg every other week, im injection) was introduced to the treatment protocol (due to previous non-compliance with haloperidol and risperidone). A significant clinical improvement was achieved and the dose during pregnancy was reduced to 200 mg once monthly and maintained to date. In both pregnancies the women gave birth to healthy girls who have been developing normally until now, at their ages of 6 months and of 3.5 years. During pregnancy and after giving birth to children the mothers’ psychiatric status and her social functioning were significantly improved and are still stable. Close monitoring of the mother’s health, a multidisciplinary approach to both her treatment and the monitoring of pregnancies as well as the complete compliance with the prescribed drug protocol were likely to be crucial for the therapeutic success. Conclusion. A favorable outcome of the present case suggests that the zuclopenthixol decanoate is a rational therapeutic option for pregnant women suffering from psychosis when the expected benefit exceed the potential risk, but a definitive evidence for its safety requires large, controlled studies. [Projekat Ministarstva nauke Republike Srbije, br. 175014]http://www.doiserbia.nb.rs/img/doi/0042-8450/2013/0042-84501300005J.pdfpsychotic disorderspregnancyrisk factorspsychotropic drugstreatment outcome |
| spellingShingle | Janjić Vladimir Milovanović Dragan R. Ružić-Zecević Dejana Lončar Dragan Laban Olivera Stepanović Marija Varjačić Mirjana Obradović Slobodan Đukić-Dejanović Slavica Janković Slobodan Zuclopenthixol decanoate in pregnancy: Successful outcomes in two consecutive off springs of the same mother Vojnosanitetski Pregled psychotic disorders pregnancy risk factors psychotropic drugs treatment outcome |
| title | Zuclopenthixol decanoate in pregnancy: Successful outcomes in two consecutive off springs of the same mother |
| title_full | Zuclopenthixol decanoate in pregnancy: Successful outcomes in two consecutive off springs of the same mother |
| title_fullStr | Zuclopenthixol decanoate in pregnancy: Successful outcomes in two consecutive off springs of the same mother |
| title_full_unstemmed | Zuclopenthixol decanoate in pregnancy: Successful outcomes in two consecutive off springs of the same mother |
| title_short | Zuclopenthixol decanoate in pregnancy: Successful outcomes in two consecutive off springs of the same mother |
| title_sort | zuclopenthixol decanoate in pregnancy successful outcomes in two consecutive off springs of the same mother |
| topic | psychotic disorders pregnancy risk factors psychotropic drugs treatment outcome |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2013/0042-84501300005J.pdf |
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