Design and synthesis of novel pyridopyrimidine moieties linked to coumarin ring of potentially active cytotoxic agents and their docking study

Abstract Many pyridopyrimidine moieties linked to the coumarin ring were synthesized by the reaction of malononitrile with 7-hydroxy-4-methyl-2-oxo-2 H-chromene-8-carbaldehyde (2) directly in the presence of ammonium acetate and different ketones and studied the effect of other basic catalysis, rati...

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Bibliographic Details
Main Authors: Nehal A. E. Youssef, Yasser A. Selim, Lina A. Shaheen, Ahmed A. Fadda, Hatem E. Gaffer, Sherihan A. El-Hadidy
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-05325-1
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