USP15 regulates radiation-induced DNA damage and intestinal injury through K48-linked deubiquitination and stabilisation of ATM

USP15 regulates radiation-induced DNA damage and intestinal injury through K48-linked deubiquitination and stabilisation of ATM

Abstract Background Radiation-induced intestinal injury (RIII) interrupts the scheduled processes of abdominal and pelvic radiotherapy (RT) and compromises the quality of life of cancer survivors. However, the specific regulators and mechanisms underlying the effects of RIII remain unknown. The biol...

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Bibliographic Details
Main Authors: Ruiqiu Zhu, Mingyue Li, Difan Wang, Chengzhi Liu, Liwei Xie, Yinyin Yang, Xuhao Gu, Kui Zhao, Ye Tian, Shang Cai
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Molecular Medicine
Subjects:
Radiation-induced intestinal injury
DNA damage response
Deubiquitination
USP15
ATM
Online Access:https://doi.org/10.1186/s10020-024-00984-8
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