Short-term alterations of brain network properties in subthreshold depression: the impact of Internet-based Cognitive Behavioral Therapy
PurposePatients with subthreshold depression (sD) carry a significant risk of developing major depressive disorder. However, few studies focus on the influence of Internet-based Cognitive Behavioral Therapy (ICBT) on brain network, particularly among Chinese undergraduates. This study aims to conduc...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-04-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1474339/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850187567016706048 |
|---|---|
| author | Wenquan Yu Yuchen Ying Li Wang YiLing Yang Li Zhang Yu Wang Zili Zhu Hui Zhang Yuning Pan |
| author_facet | Wenquan Yu Yuchen Ying Li Wang YiLing Yang Li Zhang Yu Wang Zili Zhu Hui Zhang Yuning Pan |
| author_sort | Wenquan Yu |
| collection | DOAJ |
| description | PurposePatients with subthreshold depression (sD) carry a significant risk of developing major depressive disorder. However, few studies focus on the influence of Internet-based Cognitive Behavioral Therapy (ICBT) on brain network, particularly among Chinese undergraduates. This study aims to conduct resting-state functional MRI (rs-fMRI) to explore the effects of ICBT on neurofunctional network.MethodsThis short-term longitudinal study enrolled 30 sD patients and 24 healthy matched participants. We gathered the clinical measurements outcomes from sD patients. Baseline and post-intervention MRI scans were performed for the sD patients, additionally, a matched healthy controls group underwent baseline MRI scans, functional network matrix was established from the temporal rs-MRI series. Nodal efficiency (Enod) was quantified by calculating the area under the curve (AUC) of network metrics.ResultsThe patients with sD exhibited reduced clinical measurement scores after ICBT intervention. Moreover, after ICBT intervention, functional network analysis revealed an increased Enod in the orbital part of the left inferior frontal gyrus, and decreased Enod in the left paracentral lobule and right precentral gyrus.ConclusionThis study showed alterations in brain network in patients with sD after ICBT intervention. These findings shed light on the neurofunctional mechanisms underlying the effects of ICBT in sD patients. |
| format | Article |
| id | doaj-art-9661a16309a741cea7cc21ee5ca82c0e |
| institution | OA Journals |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-9661a16309a741cea7cc21ee5ca82c0e2025-08-20T02:16:05ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-04-011610.3389/fneur.2025.14743391474339Short-term alterations of brain network properties in subthreshold depression: the impact of Internet-based Cognitive Behavioral TherapyWenquan Yu0Yuchen Ying1Li Wang2YiLing Yang3Li Zhang4Yu Wang5Zili Zhu6Hui Zhang7Yuning Pan8Department of Radiology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, ChinaNingbo College of Health Sciences, Ningbo, Zhejiang, ChinaNingbo College of Health Sciences, Ningbo, Zhejiang, ChinaNingbo College of Health Sciences, Ningbo, Zhejiang, ChinaNingbo College of Health Sciences, Ningbo, Zhejiang, ChinaDepartment of Radiology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, ChinaDepartment of Radiology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, ChinaDepartment of Radiology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, ChinaDepartment of Radiology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, ChinaPurposePatients with subthreshold depression (sD) carry a significant risk of developing major depressive disorder. However, few studies focus on the influence of Internet-based Cognitive Behavioral Therapy (ICBT) on brain network, particularly among Chinese undergraduates. This study aims to conduct resting-state functional MRI (rs-fMRI) to explore the effects of ICBT on neurofunctional network.MethodsThis short-term longitudinal study enrolled 30 sD patients and 24 healthy matched participants. We gathered the clinical measurements outcomes from sD patients. Baseline and post-intervention MRI scans were performed for the sD patients, additionally, a matched healthy controls group underwent baseline MRI scans, functional network matrix was established from the temporal rs-MRI series. Nodal efficiency (Enod) was quantified by calculating the area under the curve (AUC) of network metrics.ResultsThe patients with sD exhibited reduced clinical measurement scores after ICBT intervention. Moreover, after ICBT intervention, functional network analysis revealed an increased Enod in the orbital part of the left inferior frontal gyrus, and decreased Enod in the left paracentral lobule and right precentral gyrus.ConclusionThis study showed alterations in brain network in patients with sD after ICBT intervention. These findings shed light on the neurofunctional mechanisms underlying the effects of ICBT in sD patients.https://www.frontiersin.org/articles/10.3389/fneur.2025.1474339/fullcognitive behavioral therapynodal efficiencyleft paracentral lobulefunctional magnetic resonance imagingbrain network analysis |
| spellingShingle | Wenquan Yu Yuchen Ying Li Wang YiLing Yang Li Zhang Yu Wang Zili Zhu Hui Zhang Yuning Pan Short-term alterations of brain network properties in subthreshold depression: the impact of Internet-based Cognitive Behavioral Therapy Frontiers in Neurology cognitive behavioral therapy nodal efficiency left paracentral lobule functional magnetic resonance imaging brain network analysis |
| title | Short-term alterations of brain network properties in subthreshold depression: the impact of Internet-based Cognitive Behavioral Therapy |
| title_full | Short-term alterations of brain network properties in subthreshold depression: the impact of Internet-based Cognitive Behavioral Therapy |
| title_fullStr | Short-term alterations of brain network properties in subthreshold depression: the impact of Internet-based Cognitive Behavioral Therapy |
| title_full_unstemmed | Short-term alterations of brain network properties in subthreshold depression: the impact of Internet-based Cognitive Behavioral Therapy |
| title_short | Short-term alterations of brain network properties in subthreshold depression: the impact of Internet-based Cognitive Behavioral Therapy |
| title_sort | short term alterations of brain network properties in subthreshold depression the impact of internet based cognitive behavioral therapy |
| topic | cognitive behavioral therapy nodal efficiency left paracentral lobule functional magnetic resonance imaging brain network analysis |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1474339/full |
| work_keys_str_mv | AT wenquanyu shorttermalterationsofbrainnetworkpropertiesinsubthresholddepressiontheimpactofinternetbasedcognitivebehavioraltherapy AT yuchenying shorttermalterationsofbrainnetworkpropertiesinsubthresholddepressiontheimpactofinternetbasedcognitivebehavioraltherapy AT liwang shorttermalterationsofbrainnetworkpropertiesinsubthresholddepressiontheimpactofinternetbasedcognitivebehavioraltherapy AT yilingyang shorttermalterationsofbrainnetworkpropertiesinsubthresholddepressiontheimpactofinternetbasedcognitivebehavioraltherapy AT lizhang shorttermalterationsofbrainnetworkpropertiesinsubthresholddepressiontheimpactofinternetbasedcognitivebehavioraltherapy AT yuwang shorttermalterationsofbrainnetworkpropertiesinsubthresholddepressiontheimpactofinternetbasedcognitivebehavioraltherapy AT zilizhu shorttermalterationsofbrainnetworkpropertiesinsubthresholddepressiontheimpactofinternetbasedcognitivebehavioraltherapy AT huizhang shorttermalterationsofbrainnetworkpropertiesinsubthresholddepressiontheimpactofinternetbasedcognitivebehavioraltherapy AT yuningpan shorttermalterationsofbrainnetworkpropertiesinsubthresholddepressiontheimpactofinternetbasedcognitivebehavioraltherapy |