Design, Synthesis, and Biological Evaluation of Novel Pyrrolo [2,3-b] Pyridine Derivatives for Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) is featured with liver fat infiltration and accumulation with no connection with overdrinking. With the rising trends and no FDA-approved drugs, NAFLD attracts global attention. In this study, we successfully synthesized 18 novel SIS3 derivatives and evaluate...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2022/2386212 |
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| author | Jialin Ma Jing Li Dongping Yao Qi Wang Xinzhou Chen Feiyan Tao Bin Chen Yongmei Xie Lang Bai Yiwen Zhang |
| author_facet | Jialin Ma Jing Li Dongping Yao Qi Wang Xinzhou Chen Feiyan Tao Bin Chen Yongmei Xie Lang Bai Yiwen Zhang |
| author_sort | Jialin Ma |
| collection | DOAJ |
| description | Nonalcoholic fatty liver disease (NAFLD) is featured with liver fat infiltration and accumulation with no connection with overdrinking. With the rising trends and no FDA-approved drugs, NAFLD attracts global attention. In this study, we successfully synthesized 18 novel SIS3 derivatives and evaluated them for pharmacological activity. F-9 and F-15 had potent weight-losing effects. Importantly, intraperitoneal administration of F-9 at 10 mg·kg−1·day−1 for 5 weeks had the most excellent effects to reduce the weight of the body, liver, and fat, as well as adjusting serum levels of AST, ALT, TC, TG, HDL, and LDL. H&E staining showed that F-9 could suppress fat deposition and increase the adipocyte size in the liver. |
| format | Article |
| id | doaj-art-965de418ea56463cb9ab696759b2b292 |
| institution | Kabale University |
| issn | 2090-9071 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-965de418ea56463cb9ab696759b2b2922025-02-03T01:23:35ZengWileyJournal of Chemistry2090-90712022-01-01202210.1155/2022/2386212Design, Synthesis, and Biological Evaluation of Novel Pyrrolo [2,3-b] Pyridine Derivatives for Nonalcoholic Fatty Liver DiseaseJialin Ma0Jing Li1Dongping Yao2Qi Wang3Xinzhou Chen4Feiyan Tao5Bin Chen6Yongmei Xie7Lang Bai8Yiwen Zhang9Cancer CenterDepartment of NephrologyCancer CenterCancer CenterCancer CenterResearch and Development CentreCenter of Infectious DiseasesCancer CenterCenter of Infectious DiseasesCancer CenterNonalcoholic fatty liver disease (NAFLD) is featured with liver fat infiltration and accumulation with no connection with overdrinking. With the rising trends and no FDA-approved drugs, NAFLD attracts global attention. In this study, we successfully synthesized 18 novel SIS3 derivatives and evaluated them for pharmacological activity. F-9 and F-15 had potent weight-losing effects. Importantly, intraperitoneal administration of F-9 at 10 mg·kg−1·day−1 for 5 weeks had the most excellent effects to reduce the weight of the body, liver, and fat, as well as adjusting serum levels of AST, ALT, TC, TG, HDL, and LDL. H&E staining showed that F-9 could suppress fat deposition and increase the adipocyte size in the liver.http://dx.doi.org/10.1155/2022/2386212 |
| spellingShingle | Jialin Ma Jing Li Dongping Yao Qi Wang Xinzhou Chen Feiyan Tao Bin Chen Yongmei Xie Lang Bai Yiwen Zhang Design, Synthesis, and Biological Evaluation of Novel Pyrrolo [2,3-b] Pyridine Derivatives for Nonalcoholic Fatty Liver Disease Journal of Chemistry |
| title | Design, Synthesis, and Biological Evaluation of Novel Pyrrolo [2,3-b] Pyridine Derivatives for Nonalcoholic Fatty Liver Disease |
| title_full | Design, Synthesis, and Biological Evaluation of Novel Pyrrolo [2,3-b] Pyridine Derivatives for Nonalcoholic Fatty Liver Disease |
| title_fullStr | Design, Synthesis, and Biological Evaluation of Novel Pyrrolo [2,3-b] Pyridine Derivatives for Nonalcoholic Fatty Liver Disease |
| title_full_unstemmed | Design, Synthesis, and Biological Evaluation of Novel Pyrrolo [2,3-b] Pyridine Derivatives for Nonalcoholic Fatty Liver Disease |
| title_short | Design, Synthesis, and Biological Evaluation of Novel Pyrrolo [2,3-b] Pyridine Derivatives for Nonalcoholic Fatty Liver Disease |
| title_sort | design synthesis and biological evaluation of novel pyrrolo 2 3 b pyridine derivatives for nonalcoholic fatty liver disease |
| url | http://dx.doi.org/10.1155/2022/2386212 |
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