Structural Characterization and Anti-hyperuricemic Activity of Exopolysaccharides Secreted by Lactiplantibacillus plantarum-30
This study obtained a strain producing high yield of exopolysaccharide (EPS), which was identified as Lactiplantibacillus plantarum HZB-30. The strain produced 230.66 mg/L of EPS after fermentation for 28 h. The molecular mass of EPS produced by HZB-30 was 14 639 Da, which was composed of several mo...
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China Food Publishing Company
2025-05-01
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| Series: | Shipin Kexue |
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| Online Access: | https://www.spkx.net.cn/fileup/1002-6630/PDF/2025-46-9-016.pdf |
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| author | HAN Dong, ZHANG Jiahui, JIANG Zhengqiang, CHANG Chang |
| author_facet | HAN Dong, ZHANG Jiahui, JIANG Zhengqiang, CHANG Chang |
| author_sort | HAN Dong, ZHANG Jiahui, JIANG Zhengqiang, CHANG Chang |
| collection | DOAJ |
| description | This study obtained a strain producing high yield of exopolysaccharide (EPS), which was identified as Lactiplantibacillus plantarum HZB-30. The strain produced 230.66 mg/L of EPS after fermentation for 28 h. The molecular mass of EPS produced by HZB-30 was 14 639 Da, which was composed of several monosaccharides, such as glucose (37.76%) and galactose (19.15%). The EPS had high inhibitory activity against xanthine oxidase (XO) with an inhibition rate of 80.2%. After in vitro simulated digestion, the digestibility of the EPS was 20.7%, and 43.3% of the initial xanthine oxidase inhibitory activity remained. In an HK-2 cell model of hyperuricemia, the EPS at 20–60 μg/mL effectively decreased the levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, and IL-8 and inhibited the accumulation of uric acid. The findings from this study are both theoretically and practically important for the application of HZB-30-derived EPS to develop anti-hyperuricemic food products. |
| format | Article |
| id | doaj-art-965ccd3e3bf04240a95e9a15786f2730 |
| institution | Kabale University |
| issn | 1002-6630 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | China Food Publishing Company |
| record_format | Article |
| series | Shipin Kexue |
| spelling | doaj-art-965ccd3e3bf04240a95e9a15786f27302025-08-20T03:51:08ZengChina Food Publishing CompanyShipin Kexue1002-66302025-05-0146914815510.7506/spkx1002-6630-20241031-211Structural Characterization and Anti-hyperuricemic Activity of Exopolysaccharides Secreted by Lactiplantibacillus plantarum-30HAN Dong, ZHANG Jiahui, JIANG Zhengqiang, CHANG Chang0(Key Laboratory of Food Bioengineering (China National Light Industry), College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China)This study obtained a strain producing high yield of exopolysaccharide (EPS), which was identified as Lactiplantibacillus plantarum HZB-30. The strain produced 230.66 mg/L of EPS after fermentation for 28 h. The molecular mass of EPS produced by HZB-30 was 14 639 Da, which was composed of several monosaccharides, such as glucose (37.76%) and galactose (19.15%). The EPS had high inhibitory activity against xanthine oxidase (XO) with an inhibition rate of 80.2%. After in vitro simulated digestion, the digestibility of the EPS was 20.7%, and 43.3% of the initial xanthine oxidase inhibitory activity remained. In an HK-2 cell model of hyperuricemia, the EPS at 20–60 μg/mL effectively decreased the levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, and IL-8 and inhibited the accumulation of uric acid. The findings from this study are both theoretically and practically important for the application of HZB-30-derived EPS to develop anti-hyperuricemic food products.https://www.spkx.net.cn/fileup/1002-6630/PDF/2025-46-9-016.pdflactiplantibacillus plantarum; exopolysaccharides; structural characterization; anti-hyperuricemic activity |
| spellingShingle | HAN Dong, ZHANG Jiahui, JIANG Zhengqiang, CHANG Chang Structural Characterization and Anti-hyperuricemic Activity of Exopolysaccharides Secreted by Lactiplantibacillus plantarum-30 Shipin Kexue lactiplantibacillus plantarum; exopolysaccharides; structural characterization; anti-hyperuricemic activity |
| title | Structural Characterization and Anti-hyperuricemic Activity of Exopolysaccharides Secreted by Lactiplantibacillus plantarum-30 |
| title_full | Structural Characterization and Anti-hyperuricemic Activity of Exopolysaccharides Secreted by Lactiplantibacillus plantarum-30 |
| title_fullStr | Structural Characterization and Anti-hyperuricemic Activity of Exopolysaccharides Secreted by Lactiplantibacillus plantarum-30 |
| title_full_unstemmed | Structural Characterization and Anti-hyperuricemic Activity of Exopolysaccharides Secreted by Lactiplantibacillus plantarum-30 |
| title_short | Structural Characterization and Anti-hyperuricemic Activity of Exopolysaccharides Secreted by Lactiplantibacillus plantarum-30 |
| title_sort | structural characterization and anti hyperuricemic activity of exopolysaccharides secreted by lactiplantibacillus plantarum 30 |
| topic | lactiplantibacillus plantarum; exopolysaccharides; structural characterization; anti-hyperuricemic activity |
| url | https://www.spkx.net.cn/fileup/1002-6630/PDF/2025-46-9-016.pdf |
| work_keys_str_mv | AT handongzhangjiahuijiangzhengqiangchangchang structuralcharacterizationandantihyperuricemicactivityofexopolysaccharidessecretedbylactiplantibacillusplantarum30 |