Myokines as Possible Therapeutic Targets in Cancer Cachexia
Cachexia is an extremely serious syndrome which occurs in most patients with different cancers, and it is characterized by systemic inflammation, a negative protein and energy balance, and involuntary loss of body mass. This syndrome has a dramatic impact on the patient’s quality of life, and it is...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/8260742 |
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| _version_ | 1832552580435148800 |
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| author | Emilia Manole Laura C. Ceafalan Bogdan O. Popescu Carmen Dumitru Alexandra E. Bastian |
| author_facet | Emilia Manole Laura C. Ceafalan Bogdan O. Popescu Carmen Dumitru Alexandra E. Bastian |
| author_sort | Emilia Manole |
| collection | DOAJ |
| description | Cachexia is an extremely serious syndrome which occurs in most patients with different cancers, and it is characterized by systemic inflammation, a negative protein and energy balance, and involuntary loss of body mass. This syndrome has a dramatic impact on the patient’s quality of life, and it is also associated with a low response to chemotherapy leading to a decrease in survival. Despite this, cachexia is still underestimated and often untreated. New research is needed in this area to understand this complex phenomenon and ultimately find treatment methods and therapeutic targets. The skeletal muscle can act as an endocrine organ. Signaling between muscles and other systems is done through myokines, cytokines, and proteins produced and released by myocytes. In this review, we would like to draw attention to some of the most important myokines that could have potential as biomarkers and therapeutic targets: myostatin, irisin, myonectin, decorin, fibroblast growth factor 21, interleukin-6, interleukin-8, and interleukin-15. |
| format | Article |
| id | doaj-art-965cc3bd32994f51aab15f252b7880d9 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-965cc3bd32994f51aab15f252b7880d92025-02-03T05:58:18ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/82607428260742Myokines as Possible Therapeutic Targets in Cancer CachexiaEmilia Manole0Laura C. Ceafalan1Bogdan O. Popescu2Carmen Dumitru3Alexandra E. Bastian4Molecular Biology Department, “Victor Babeș” National Institute of Pathology, Bucharest, RomaniaUltrastructural Pathology Laboratory, “Victor Babeș” National Institute of Pathology, Bucharest, RomaniaMolecular Biology Department, “Victor Babeș” National Institute of Pathology, Bucharest, RomaniaResearch Center, Pathology Department, Colentina Clinical Hospital, Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, Bucharest, RomaniaCachexia is an extremely serious syndrome which occurs in most patients with different cancers, and it is characterized by systemic inflammation, a negative protein and energy balance, and involuntary loss of body mass. This syndrome has a dramatic impact on the patient’s quality of life, and it is also associated with a low response to chemotherapy leading to a decrease in survival. Despite this, cachexia is still underestimated and often untreated. New research is needed in this area to understand this complex phenomenon and ultimately find treatment methods and therapeutic targets. The skeletal muscle can act as an endocrine organ. Signaling between muscles and other systems is done through myokines, cytokines, and proteins produced and released by myocytes. In this review, we would like to draw attention to some of the most important myokines that could have potential as biomarkers and therapeutic targets: myostatin, irisin, myonectin, decorin, fibroblast growth factor 21, interleukin-6, interleukin-8, and interleukin-15.http://dx.doi.org/10.1155/2018/8260742 |
| spellingShingle | Emilia Manole Laura C. Ceafalan Bogdan O. Popescu Carmen Dumitru Alexandra E. Bastian Myokines as Possible Therapeutic Targets in Cancer Cachexia Journal of Immunology Research |
| title | Myokines as Possible Therapeutic Targets in Cancer Cachexia |
| title_full | Myokines as Possible Therapeutic Targets in Cancer Cachexia |
| title_fullStr | Myokines as Possible Therapeutic Targets in Cancer Cachexia |
| title_full_unstemmed | Myokines as Possible Therapeutic Targets in Cancer Cachexia |
| title_short | Myokines as Possible Therapeutic Targets in Cancer Cachexia |
| title_sort | myokines as possible therapeutic targets in cancer cachexia |
| url | http://dx.doi.org/10.1155/2018/8260742 |
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