Severe thyroiditis induced by sintilimab monotherapy in a patient with non-small cell lung cancer: a case report and literature review

Severe thyroiditis induced by sintilimab monotherapy in a patient with non-small cell lung cancer: a case report and literature review

Thyroid dysfunction is a common immune-related adverse event (irAE) associated with immune checkpoint inhibitors (ICIs) that target PD-1, PD-L1, and CTLA-4. Nevertheless, the incidence of severe cases, defined as grade 3 or higher, remains rare. This report presents a detailed case study of severe t...

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Bibliographic Details
Main Authors: Xiaolin Zhao, Xiaoyu Wang, Surui Liu, Pian Cheng, Jinjuan Chen, Jie Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
sintilimab
irAEs
thyroiditis
NSCLC
case report
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1548452/full
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