The current landscape of artificial intelligence in computational histopathology for cancer diagnosis

Abstract Artificial intelligence (AI) marks a frontier in histopathologic analysis shift towards the clinic, becoming a mainstream choice to interpret histological images. Surveying studies assessing AI applications in histopathology from 2013 to 2024, we review key methods (including supervised, un...

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Main Authors: Aaditya Tiwari, Aruni Ghose, Maryam Hasanova, Sara Socorro Faria, Srishti Mohapatra, Sola Adeleke, Stergios Boussios
Format: Article
Language:English
Published: Springer 2025-04-01
Series:Discover Oncology
Subjects:
Online Access:https://doi.org/10.1007/s12672-025-02212-z
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author Aaditya Tiwari
Aruni Ghose
Maryam Hasanova
Sara Socorro Faria
Srishti Mohapatra
Sola Adeleke
Stergios Boussios
author_facet Aaditya Tiwari
Aruni Ghose
Maryam Hasanova
Sara Socorro Faria
Srishti Mohapatra
Sola Adeleke
Stergios Boussios
author_sort Aaditya Tiwari
collection DOAJ
description Abstract Artificial intelligence (AI) marks a frontier in histopathologic analysis shift towards the clinic, becoming a mainstream choice to interpret histological images. Surveying studies assessing AI applications in histopathology from 2013 to 2024, we review key methods (including supervised, unsupervised, weakly supervised and transfer learning) in deep learning-based pattern recognition in computational histopathology for diagnostic and prognostic purposes. Deep learning methods also showed utility in identifying a wide range of genetic mutations and standard pathology biomarkers from routine histology. This survey of 41 primary studies also encompasses key regions of AI applicability in histopathology in a multi-cancer review while marking prospects to introduce AI into the clinical setting with key examples including Swarm Learning and Data Fusion.
format Article
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issn 2730-6011
language English
publishDate 2025-04-01
publisher Springer
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series Discover Oncology
spelling doaj-art-964e85cecf054d82a9759774b64d458e2025-08-20T03:07:43ZengSpringerDiscover Oncology2730-60112025-04-0116112510.1007/s12672-025-02212-zThe current landscape of artificial intelligence in computational histopathology for cancer diagnosisAaditya Tiwari0Aruni Ghose1Maryam Hasanova2Sara Socorro Faria3Srishti Mohapatra4Sola Adeleke5Stergios Boussios6Barts and the London School of Medicine and Dentistry, Queen Mary University of LondonBarts Cancer Institute, Cancer Research UK City of London Centre, Queen Mary University of LondonOncoFlowTMLaboratory of Immunology and Inflammation, Department of Cell Biology, University of BrasiliaGeneral Internal Medicine Doctorate Programme, University of HertfordshireSchool of Biomedical Engineering & Imaging Sciences, King’s College LondonDepartment of Medical Oncology, Medway NHS Foundation TrustAbstract Artificial intelligence (AI) marks a frontier in histopathologic analysis shift towards the clinic, becoming a mainstream choice to interpret histological images. Surveying studies assessing AI applications in histopathology from 2013 to 2024, we review key methods (including supervised, unsupervised, weakly supervised and transfer learning) in deep learning-based pattern recognition in computational histopathology for diagnostic and prognostic purposes. Deep learning methods also showed utility in identifying a wide range of genetic mutations and standard pathology biomarkers from routine histology. This survey of 41 primary studies also encompasses key regions of AI applicability in histopathology in a multi-cancer review while marking prospects to introduce AI into the clinical setting with key examples including Swarm Learning and Data Fusion.https://doi.org/10.1007/s12672-025-02212-zArtificial IntelligenceMachine LearningDeep LearningCancerHistopathologyComputational
spellingShingle Aaditya Tiwari
Aruni Ghose
Maryam Hasanova
Sara Socorro Faria
Srishti Mohapatra
Sola Adeleke
Stergios Boussios
The current landscape of artificial intelligence in computational histopathology for cancer diagnosis
Discover Oncology
Artificial Intelligence
Machine Learning
Deep Learning
Cancer
Histopathology
Computational
title The current landscape of artificial intelligence in computational histopathology for cancer diagnosis
title_full The current landscape of artificial intelligence in computational histopathology for cancer diagnosis
title_fullStr The current landscape of artificial intelligence in computational histopathology for cancer diagnosis
title_full_unstemmed The current landscape of artificial intelligence in computational histopathology for cancer diagnosis
title_short The current landscape of artificial intelligence in computational histopathology for cancer diagnosis
title_sort current landscape of artificial intelligence in computational histopathology for cancer diagnosis
topic Artificial Intelligence
Machine Learning
Deep Learning
Cancer
Histopathology
Computational
url https://doi.org/10.1007/s12672-025-02212-z
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