The cell autonomous and non-autonomous roles of itaconate in immune response
Itaconate which is discovered as a mammalian metabolite possessing antimicrobial and immunoregulatory activity has attracted much attention in the field of immunometabolism. Itaconate is synthesized by myeloid cells under conditions of pathogen infection and sterile inflammation. In addition to regu...
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| Format: | Article |
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Elsevier
2025-02-01
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| Series: | Cell Insight |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772892724000798 |
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| author | Chao Chen Xinjian Li |
| author_facet | Chao Chen Xinjian Li |
| author_sort | Chao Chen |
| collection | DOAJ |
| description | Itaconate which is discovered as a mammalian metabolite possessing antimicrobial and immunoregulatory activity has attracted much attention in the field of immunometabolism. Itaconate is synthesized by myeloid cells under conditions of pathogen infection and sterile inflammation. In addition to regulating immune response of myeloid cells, itaconate secreted from myeloid cells can also be taken up by non-myeloid cells to exert immunoregulatory effects in a cell non-autonomous manner. In this review, we recap the discovery of itaconate as a distinct immunologic regulator and effector, describe the development of itaconate biosensor, and detail the recent findings that decipher the mechanism underlying intercellular transport of itaconate. Based on these knowledges, we propose itaconate is a messenger transmitting immunologic signals from myeloid cells to other types of cells during host inflammation and immune defense. |
| format | Article |
| id | doaj-art-964a6e27945847fbb5245f0d18332e58 |
| institution | Kabale University |
| issn | 2772-8927 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Insight |
| spelling | doaj-art-964a6e27945847fbb5245f0d18332e582025-01-30T05:15:18ZengElsevierCell Insight2772-89272025-02-0141100224The cell autonomous and non-autonomous roles of itaconate in immune responseChao Chen0Xinjian Li1Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, ChinaKey Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China; Corresponding author. Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.Itaconate which is discovered as a mammalian metabolite possessing antimicrobial and immunoregulatory activity has attracted much attention in the field of immunometabolism. Itaconate is synthesized by myeloid cells under conditions of pathogen infection and sterile inflammation. In addition to regulating immune response of myeloid cells, itaconate secreted from myeloid cells can also be taken up by non-myeloid cells to exert immunoregulatory effects in a cell non-autonomous manner. In this review, we recap the discovery of itaconate as a distinct immunologic regulator and effector, describe the development of itaconate biosensor, and detail the recent findings that decipher the mechanism underlying intercellular transport of itaconate. Based on these knowledges, we propose itaconate is a messenger transmitting immunologic signals from myeloid cells to other types of cells during host inflammation and immune defense.http://www.sciencedirect.com/science/article/pii/S2772892724000798ItaconateIRG1ImmunometabolismImmunotransmitterInnate immunityInflammation |
| spellingShingle | Chao Chen Xinjian Li The cell autonomous and non-autonomous roles of itaconate in immune response Cell Insight Itaconate IRG1 Immunometabolism Immunotransmitter Innate immunity Inflammation |
| title | The cell autonomous and non-autonomous roles of itaconate in immune response |
| title_full | The cell autonomous and non-autonomous roles of itaconate in immune response |
| title_fullStr | The cell autonomous and non-autonomous roles of itaconate in immune response |
| title_full_unstemmed | The cell autonomous and non-autonomous roles of itaconate in immune response |
| title_short | The cell autonomous and non-autonomous roles of itaconate in immune response |
| title_sort | cell autonomous and non autonomous roles of itaconate in immune response |
| topic | Itaconate IRG1 Immunometabolism Immunotransmitter Innate immunity Inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S2772892724000798 |
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