Revelations from the Nematode Caenorhabditis elegans on the Complex Interplay of Metal Toxicological Mechanisms
Metals have been definitively linked to a number of disease states. Due to the widespread existence of metals in our environment from both natural and anthropogenic sources, understanding the mechanisms of their cellular detoxification is of upmost importance. Organisms have evolved cellular detoxif...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2011/895236 |
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| author | Ebany J. Martinez-Finley Michael Aschner |
| author_facet | Ebany J. Martinez-Finley Michael Aschner |
| author_sort | Ebany J. Martinez-Finley |
| collection | DOAJ |
| description | Metals have been definitively linked to a number of disease states. Due to the widespread existence of metals in our environment from both natural and anthropogenic sources, understanding the mechanisms of their cellular detoxification is of upmost importance. Organisms have evolved cellular detoxification systems including glutathione, metallothioneins, pumps and transporters, and heat shock proteins to regulate intracellular metal levels. The model organism, Caenorhabditis elegans (C. elegans), contains these systems and provides several advantages for deciphering the mechanisms of metal detoxification. This review provides a brief summary of contemporary literature on the various mechanisms involved in the cellular detoxification of metals, specifically, antimony, arsenic, cadmium, copper, manganese, mercury, and depleted uranium using the C. elegans model system for investigation and analysis. |
| format | Article |
| id | doaj-art-9645bc35a67243d5860e857c32e58aa0 |
| institution | OA Journals |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-9645bc35a67243d5860e857c32e58aa02025-08-20T02:10:13ZengWileyJournal of Toxicology1687-81911687-82052011-01-01201110.1155/2011/895236895236Revelations from the Nematode Caenorhabditis elegans on the Complex Interplay of Metal Toxicological MechanismsEbany J. Martinez-Finley0Michael Aschner1Division of Pediatric Clinical Pharmacology and Toxicology, Vanderbilt University Medical Center, Nashville, USADivision of Pediatric Clinical Pharmacology and Toxicology, Vanderbilt University Medical Center, Nashville, USAMetals have been definitively linked to a number of disease states. Due to the widespread existence of metals in our environment from both natural and anthropogenic sources, understanding the mechanisms of their cellular detoxification is of upmost importance. Organisms have evolved cellular detoxification systems including glutathione, metallothioneins, pumps and transporters, and heat shock proteins to regulate intracellular metal levels. The model organism, Caenorhabditis elegans (C. elegans), contains these systems and provides several advantages for deciphering the mechanisms of metal detoxification. This review provides a brief summary of contemporary literature on the various mechanisms involved in the cellular detoxification of metals, specifically, antimony, arsenic, cadmium, copper, manganese, mercury, and depleted uranium using the C. elegans model system for investigation and analysis.http://dx.doi.org/10.1155/2011/895236 |
| spellingShingle | Ebany J. Martinez-Finley Michael Aschner Revelations from the Nematode Caenorhabditis elegans on the Complex Interplay of Metal Toxicological Mechanisms Journal of Toxicology |
| title | Revelations from the Nematode Caenorhabditis elegans on the Complex Interplay of Metal Toxicological Mechanisms |
| title_full | Revelations from the Nematode Caenorhabditis elegans on the Complex Interplay of Metal Toxicological Mechanisms |
| title_fullStr | Revelations from the Nematode Caenorhabditis elegans on the Complex Interplay of Metal Toxicological Mechanisms |
| title_full_unstemmed | Revelations from the Nematode Caenorhabditis elegans on the Complex Interplay of Metal Toxicological Mechanisms |
| title_short | Revelations from the Nematode Caenorhabditis elegans on the Complex Interplay of Metal Toxicological Mechanisms |
| title_sort | revelations from the nematode caenorhabditis elegans on the complex interplay of metal toxicological mechanisms |
| url | http://dx.doi.org/10.1155/2011/895236 |
| work_keys_str_mv | AT ebanyjmartinezfinley revelationsfromthenematodecaenorhabditiselegansonthecomplexinterplayofmetaltoxicologicalmechanisms AT michaelaschner revelationsfromthenematodecaenorhabditiselegansonthecomplexinterplayofmetaltoxicologicalmechanisms |