PRIMERS: Polydopamine Radioimmunotherapy with Image-Guided Monitoring and Enhanced Release System
<b>Background/Objectives:</b> To overcome the side effects of conventional cancer treatment, multifunctional nanoparticles with image-guidance properties are increasingly desired to obtain enhanced therapeutic efficacy without any toxicity of the treatment. Herein, we introduce the poten...
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2024-11-01
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| author | Shahinur Acter Lindokuhle M. Ngema Michele Moreau Debarghya China Akila Viswanathan Kai Ding Yahya E. Choonara Sayeda Yasmin-Karim Wilfred Ngwa |
| author_facet | Shahinur Acter Lindokuhle M. Ngema Michele Moreau Debarghya China Akila Viswanathan Kai Ding Yahya E. Choonara Sayeda Yasmin-Karim Wilfred Ngwa |
| author_sort | Shahinur Acter |
| collection | DOAJ |
| description | <b>Background/Objectives:</b> To overcome the side effects of conventional cancer treatment, multifunctional nanoparticles with image-guidance properties are increasingly desired to obtain enhanced therapeutic efficacy without any toxicity of the treatment. Herein, we introduce the potential of Polydopamine Radioimmunotherapy with Image-guided Monitoring and Enhanced (drug) Release System (PRIMERS) to meet the challenges of currently used cancer therapy. <b>Methods:</b> The PDA nanobowls were synthesized using an emulsion-induced interfacial anisotropic assembly method followed by surface modification with high-Z material to obtained the final product PRIMERS. <b>Results:</b> The engineered multifunctional nanosystem “PRIMERS” could serve as fiducial markers with the potential for use in combination cancer therapy. By leveraging the advantages of the excellent surface functionalization capability of PDA, the anisotropic nanostructure (PDA nanobowls) has been successfully functionalized with gadolinium, which shows strong MRI contrast signal both in vitro in phantom and in vivo in animals. The results of anti-cancer drug loading and releasing efficiency of these functionalized nanobowls are presented. Moreover, the gadolinium-coated PDA nanobowls demonstrate the capacity for loading immunotherapy drugs (Anti-CD40) with activated release in acidic pH levels characteristic of the tumor microenvironment, with enhanced release following administration of radiation therapy in vitro. <b>Conclusions:</b> Overall, the results highlight the potential of this new technology for combining radiotherapy with activated image-guided drug delivery, which offers broad opportunities to overcome current challenges in cancer treatment. |
| format | Article |
| id | doaj-art-96437e28f73a4345ade7fcae50cf7e85 |
| institution | OA Journals |
| issn | 1999-4923 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-96437e28f73a4345ade7fcae50cf7e852025-08-20T02:05:01ZengMDPI AGPharmaceutics1999-49232024-11-011611148110.3390/pharmaceutics16111481PRIMERS: Polydopamine Radioimmunotherapy with Image-Guided Monitoring and Enhanced Release SystemShahinur Acter0Lindokuhle M. Ngema1Michele Moreau2Debarghya China3Akila Viswanathan4Kai Ding5Yahya E. Choonara6Sayeda Yasmin-Karim7Wilfred Ngwa8Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USADepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USADepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USADepartment of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21287, USADepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USADepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USAWITS Advanced Drug Delivery Platform Research Unit, Department of Pharmacy & Pharmacology, University of Witwatersrand, 7 York Road, Parktown, Johannesburg 2193, South AfricaDepartment of Radiation Oncology, Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Boston, MA 02115, USADepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA<b>Background/Objectives:</b> To overcome the side effects of conventional cancer treatment, multifunctional nanoparticles with image-guidance properties are increasingly desired to obtain enhanced therapeutic efficacy without any toxicity of the treatment. Herein, we introduce the potential of Polydopamine Radioimmunotherapy with Image-guided Monitoring and Enhanced (drug) Release System (PRIMERS) to meet the challenges of currently used cancer therapy. <b>Methods:</b> The PDA nanobowls were synthesized using an emulsion-induced interfacial anisotropic assembly method followed by surface modification with high-Z material to obtained the final product PRIMERS. <b>Results:</b> The engineered multifunctional nanosystem “PRIMERS” could serve as fiducial markers with the potential for use in combination cancer therapy. By leveraging the advantages of the excellent surface functionalization capability of PDA, the anisotropic nanostructure (PDA nanobowls) has been successfully functionalized with gadolinium, which shows strong MRI contrast signal both in vitro in phantom and in vivo in animals. The results of anti-cancer drug loading and releasing efficiency of these functionalized nanobowls are presented. Moreover, the gadolinium-coated PDA nanobowls demonstrate the capacity for loading immunotherapy drugs (Anti-CD40) with activated release in acidic pH levels characteristic of the tumor microenvironment, with enhanced release following administration of radiation therapy in vitro. <b>Conclusions:</b> Overall, the results highlight the potential of this new technology for combining radiotherapy with activated image-guided drug delivery, which offers broad opportunities to overcome current challenges in cancer treatment.https://www.mdpi.com/1999-4923/16/11/1481polydopamineimage-guided drug releasefiducial markerscancercombination therapymesoporous bowl-shaped nanoparticles |
| spellingShingle | Shahinur Acter Lindokuhle M. Ngema Michele Moreau Debarghya China Akila Viswanathan Kai Ding Yahya E. Choonara Sayeda Yasmin-Karim Wilfred Ngwa PRIMERS: Polydopamine Radioimmunotherapy with Image-Guided Monitoring and Enhanced Release System Pharmaceutics polydopamine image-guided drug release fiducial markers cancer combination therapy mesoporous bowl-shaped nanoparticles |
| title | PRIMERS: Polydopamine Radioimmunotherapy with Image-Guided Monitoring and Enhanced Release System |
| title_full | PRIMERS: Polydopamine Radioimmunotherapy with Image-Guided Monitoring and Enhanced Release System |
| title_fullStr | PRIMERS: Polydopamine Radioimmunotherapy with Image-Guided Monitoring and Enhanced Release System |
| title_full_unstemmed | PRIMERS: Polydopamine Radioimmunotherapy with Image-Guided Monitoring and Enhanced Release System |
| title_short | PRIMERS: Polydopamine Radioimmunotherapy with Image-Guided Monitoring and Enhanced Release System |
| title_sort | primers polydopamine radioimmunotherapy with image guided monitoring and enhanced release system |
| topic | polydopamine image-guided drug release fiducial markers cancer combination therapy mesoporous bowl-shaped nanoparticles |
| url | https://www.mdpi.com/1999-4923/16/11/1481 |
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