Increased serum interleukin-9 and interleukin-1β are associated with depression in type 2 diabetes patients
ABSTRACT Background: Co-morbid diabetes and depression are prevalent chronic conditions negatively affecting quality of life (QoL). Inflammation has been considered as an integral mechanism in patients with both diabetes and depression. Objective: The aim of the present study was to investigate...
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| Series: | Arquivos de Neuro-Psiquiatria |
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| author | Prabhat VARSHNEY Rizwana PARVEEN Mohd Ashif KHAN Sunil KOHLI Nidhi B. AGARWAL |
| author_facet | Prabhat VARSHNEY Rizwana PARVEEN Mohd Ashif KHAN Sunil KOHLI Nidhi B. AGARWAL |
| author_sort | Prabhat VARSHNEY |
| collection | DOAJ |
| description | ABSTRACT Background: Co-morbid diabetes and depression are prevalent chronic conditions negatively affecting quality of life (QoL). Inflammation has been considered as an integral mechanism in patients with both diabetes and depression. Objective: The aim of the present study was to investigate depression and its association with interleukins (IL)-1β and IL-9 in type 2 diabetic patients (T2DM) and controls. The QoL in diabetic patient was also assessed. Methods: Eighty subjects were included, distributed among three groups: Group 1 - Healthy controls; Group 2 - T2DM patients without depression; Group 3 - T2DM patients with depression. Depression and QoL were assessed using Patient Health Questionnaire (PHQ-9) and The Audit of Diabetes-Dependent QoL (ADDQoL), respectively. IL-1β and IL-9 were measured in serum samples of all the patients using ELISA kit. Results: The PHQ score in the Group 3 was significantly higher as compared to Group 1. The ADDQoL scores in the Group 3 were significantly higher as compared to Group 2. Levels of IL-9 and IL-1β were elevated in Group 3, as compared to the other groups. Conclusion: This study showed positive association between depression and IL-1β, IL-9 in T2DM patients. Additionally, the diabetic patients have poorer quality of life, which is further worsened by the presence of depression. Thus, routine assessment for the presence of depression is suggested in T2DM patients. |
| format | Article |
| id | doaj-art-964241e9a7b341d3ac46d8cd62b35c61 |
| institution | OA Journals |
| issn | 0004-282X 1678-4227 |
| language | English |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-964241e9a7b341d3ac46d8cd62b35c612025-08-20T02:10:13ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria0004-282X1678-422778525526110.1590/0004-282x20190177S0004-282X2020000500255Increased serum interleukin-9 and interleukin-1β are associated with depression in type 2 diabetes patientsPrabhat VARSHNEYRizwana PARVEENMohd Ashif KHANSunil KOHLINidhi B. AGARWALABSTRACT Background: Co-morbid diabetes and depression are prevalent chronic conditions negatively affecting quality of life (QoL). Inflammation has been considered as an integral mechanism in patients with both diabetes and depression. Objective: The aim of the present study was to investigate depression and its association with interleukins (IL)-1β and IL-9 in type 2 diabetic patients (T2DM) and controls. The QoL in diabetic patient was also assessed. Methods: Eighty subjects were included, distributed among three groups: Group 1 - Healthy controls; Group 2 - T2DM patients without depression; Group 3 - T2DM patients with depression. Depression and QoL were assessed using Patient Health Questionnaire (PHQ-9) and The Audit of Diabetes-Dependent QoL (ADDQoL), respectively. IL-1β and IL-9 were measured in serum samples of all the patients using ELISA kit. Results: The PHQ score in the Group 3 was significantly higher as compared to Group 1. The ADDQoL scores in the Group 3 were significantly higher as compared to Group 2. Levels of IL-9 and IL-1β were elevated in Group 3, as compared to the other groups. Conclusion: This study showed positive association between depression and IL-1β, IL-9 in T2DM patients. Additionally, the diabetic patients have poorer quality of life, which is further worsened by the presence of depression. Thus, routine assessment for the presence of depression is suggested in T2DM patients.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2020000500255&lng=en&tlng=encytokinesdepressionpatient health questionnaire |
| spellingShingle | Prabhat VARSHNEY Rizwana PARVEEN Mohd Ashif KHAN Sunil KOHLI Nidhi B. AGARWAL Increased serum interleukin-9 and interleukin-1β are associated with depression in type 2 diabetes patients Arquivos de Neuro-Psiquiatria cytokines depression patient health questionnaire |
| title | Increased serum interleukin-9 and interleukin-1β are associated with depression in type 2 diabetes patients |
| title_full | Increased serum interleukin-9 and interleukin-1β are associated with depression in type 2 diabetes patients |
| title_fullStr | Increased serum interleukin-9 and interleukin-1β are associated with depression in type 2 diabetes patients |
| title_full_unstemmed | Increased serum interleukin-9 and interleukin-1β are associated with depression in type 2 diabetes patients |
| title_short | Increased serum interleukin-9 and interleukin-1β are associated with depression in type 2 diabetes patients |
| title_sort | increased serum interleukin 9 and interleukin 1β are associated with depression in type 2 diabetes patients |
| topic | cytokines depression patient health questionnaire |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2020000500255&lng=en&tlng=en |
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