THE ADHERENCE TO RECOMMENDED THERAPY IN PATIENTS AFTER ACUTE CORONARY SYNDROME, AND RISK OF CARDIOVASCULAR COMPLICATIONS WITHIN A YEAR AFTER HOSPITAL ADMISSION
Aim. In patients after acute coronary syndrome (ACS) to study the effect of adherence to recommended therapy on the risk of cardiovascular events during a year after hospital admission, and to identify the main causes of low adherence to prescribed therapy. Material and methods. Patients with ACS (n...
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Столичная издательская компания
2016-01-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/900 |
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| author | N. F. Puchin'yan Ya. P. Dovgalevskiy P. V. Dolotovskaya N. V. Furman |
| author_facet | N. F. Puchin'yan Ya. P. Dovgalevskiy P. V. Dolotovskaya N. V. Furman |
| author_sort | N. F. Puchin'yan |
| collection | DOAJ |
| description | Aim. In patients after acute coronary syndrome (ACS) to study the effect of adherence to recommended therapy on the risk of cardiovascular events during a year after hospital admission, and to identify the main causes of low adherence to prescribed therapy. Material and methods. Patients with ACS (n=271), consistently admitting to the emergency cardiology department were included into the study. Complex therapy (acetylsalicylic acid (ASA), beta-blockers (BB), ACE inhibitors, statins) was prescribed to all patients. The drugs prescription rate was analyzed. The cardiovascular events (death, myocardial infarction, stroke, episodes of unstable angina, decompensated heart failure) were recorded for 12 months. The adherence of patients to recommended therapy was evaluated. Results. After hospital discharge ASA therapy was recommended to 98% of patients, BB — 95%, ACE inhibitors — 97%, statins — 63%. In 12 months only 73% of patients continued therapy with ASA, 66% — BB, 74% — ACE inhibitors, 44% — statins. The rate of hospital re-admission was significantly higher in patients with low adherence: 80% (n=32) vs 24% (n=55) among compliant patients. The main causes of hospital re-admission were decompensated heart failure (46%), recurrent episodes of angina (32%) or ACS (19%). Conclusion. A significant part of patients (about 1/3) terminates the recommended therapy within 12 months after ACS. Low adherence to therapy is often determined by subjective factors and associated with a 3-fold increased risk of cardiovascular events (RR 3.27; 95% CI 2.49-4.30; p=0.05). |
| format | Article |
| id | doaj-art-964176b3e4db49bbb50fafb26a81b376 |
| institution | Kabale University |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-964176b3e4db49bbb50fafb26a81b3762025-08-23T10:00:23ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532016-01-017556757310.20996/1819-6446-2011-7-5-57-61899THE ADHERENCE TO RECOMMENDED THERAPY IN PATIENTS AFTER ACUTE CORONARY SYNDROME, AND RISK OF CARDIOVASCULAR COMPLICATIONS WITHIN A YEAR AFTER HOSPITAL ADMISSIONN. F. Puchin'yan0Ya. P. Dovgalevskiy1P. V. Dolotovskaya2N. V. Furman3Saratov Research Institute for CardiologySaratov Research Institute for CardiologySaratov Research Institute for CardiologySaratov Research Institute for CardiologyAim. In patients after acute coronary syndrome (ACS) to study the effect of adherence to recommended therapy on the risk of cardiovascular events during a year after hospital admission, and to identify the main causes of low adherence to prescribed therapy. Material and methods. Patients with ACS (n=271), consistently admitting to the emergency cardiology department were included into the study. Complex therapy (acetylsalicylic acid (ASA), beta-blockers (BB), ACE inhibitors, statins) was prescribed to all patients. The drugs prescription rate was analyzed. The cardiovascular events (death, myocardial infarction, stroke, episodes of unstable angina, decompensated heart failure) were recorded for 12 months. The adherence of patients to recommended therapy was evaluated. Results. After hospital discharge ASA therapy was recommended to 98% of patients, BB — 95%, ACE inhibitors — 97%, statins — 63%. In 12 months only 73% of patients continued therapy with ASA, 66% — BB, 74% — ACE inhibitors, 44% — statins. The rate of hospital re-admission was significantly higher in patients with low adherence: 80% (n=32) vs 24% (n=55) among compliant patients. The main causes of hospital re-admission were decompensated heart failure (46%), recurrent episodes of angina (32%) or ACS (19%). Conclusion. A significant part of patients (about 1/3) terminates the recommended therapy within 12 months after ACS. Low adherence to therapy is often determined by subjective factors and associated with a 3-fold increased risk of cardiovascular events (RR 3.27; 95% CI 2.49-4.30; p=0.05).https://www.rpcardio.online/jour/article/view/900ischemic heart diseaseacute coronary syndromeadherence to therapyprognosisefficacy of therapy |
| spellingShingle | N. F. Puchin'yan Ya. P. Dovgalevskiy P. V. Dolotovskaya N. V. Furman THE ADHERENCE TO RECOMMENDED THERAPY IN PATIENTS AFTER ACUTE CORONARY SYNDROME, AND RISK OF CARDIOVASCULAR COMPLICATIONS WITHIN A YEAR AFTER HOSPITAL ADMISSION Рациональная фармакотерапия в кардиологии ischemic heart disease acute coronary syndrome adherence to therapy prognosis efficacy of therapy |
| title | THE ADHERENCE TO RECOMMENDED THERAPY IN PATIENTS AFTER ACUTE CORONARY SYNDROME, AND RISK OF CARDIOVASCULAR COMPLICATIONS WITHIN A YEAR AFTER HOSPITAL ADMISSION |
| title_full | THE ADHERENCE TO RECOMMENDED THERAPY IN PATIENTS AFTER ACUTE CORONARY SYNDROME, AND RISK OF CARDIOVASCULAR COMPLICATIONS WITHIN A YEAR AFTER HOSPITAL ADMISSION |
| title_fullStr | THE ADHERENCE TO RECOMMENDED THERAPY IN PATIENTS AFTER ACUTE CORONARY SYNDROME, AND RISK OF CARDIOVASCULAR COMPLICATIONS WITHIN A YEAR AFTER HOSPITAL ADMISSION |
| title_full_unstemmed | THE ADHERENCE TO RECOMMENDED THERAPY IN PATIENTS AFTER ACUTE CORONARY SYNDROME, AND RISK OF CARDIOVASCULAR COMPLICATIONS WITHIN A YEAR AFTER HOSPITAL ADMISSION |
| title_short | THE ADHERENCE TO RECOMMENDED THERAPY IN PATIENTS AFTER ACUTE CORONARY SYNDROME, AND RISK OF CARDIOVASCULAR COMPLICATIONS WITHIN A YEAR AFTER HOSPITAL ADMISSION |
| title_sort | adherence to recommended therapy in patients after acute coronary syndrome and risk of cardiovascular complications within a year after hospital admission |
| topic | ischemic heart disease acute coronary syndrome adherence to therapy prognosis efficacy of therapy |
| url | https://www.rpcardio.online/jour/article/view/900 |
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