Sodium permeable and “hypersensitive” TREK‐1 channels cause ventricular tachycardia

Sodium permeable and “hypersensitive” TREK‐1 channels cause ventricular tachycardia

Abstract In a patient with right ventricular outflow tract (RVOT) tachycardia, we identified a heterozygous point mutation in the selectivity filter of the stretch‐activated K2P potassium channel TREK‐1 (KCNK2 or K2P2.1). This mutation introduces abnormal sodium permeability to TREK‐1. In addition,...

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Main Authors: Niels Decher, Beatriz Ortiz‐Bonnin, Corinna Friedrich, Marcus Schewe, Aytug K Kiper, Susanne Rinné, Gunnar Seemann, Rémi Peyronnet, Sven Zumhagen, Daniel Bustos, Jens Kockskämper, Peter Kohl, Steffen Just, Wendy González, Thomas Baukrowitz, Birgit Stallmeyer, Eric Schulze‐Bahr
Format: Article
Language:English
Published: Springer Nature 2017-02-01
Series:EMBO Molecular Medicine
Subjects:
arrhythmia
K2P
RVOT
TREK‐1
two‐pore domain K+ channel
Online Access:https://doi.org/10.15252/emmm.201606690
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