Biogenic synthesis of silver nanoparticles (AgNPs) from Allium jacquemontii extract and its assessment in different biological activities
Abstract Nanotechnology is a vibrant and fast-developing field in science with diverse applications. Silver nanoparticles (AgNPs) are becoming gradually valuable because of their exceptional antimicrobial properties and remarkable physical characteristics. This study reports the phytochemical screen...
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Nature Portfolio
2025-07-01
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| Online Access: | https://doi.org/10.1038/s41598-025-10828-y |
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| author | Asif Kamal Moona Nazish Tehmina Siddique Muhammad Azhar Khan Narjis Khatoon Ghulam Mujtaba Shah Jawaher Alzahrani Wasim Akhtar Shoaib Noor Muhammad Tahir Naseem Wajid Zaman |
| author_facet | Asif Kamal Moona Nazish Tehmina Siddique Muhammad Azhar Khan Narjis Khatoon Ghulam Mujtaba Shah Jawaher Alzahrani Wasim Akhtar Shoaib Noor Muhammad Tahir Naseem Wajid Zaman |
| author_sort | Asif Kamal |
| collection | DOAJ |
| description | Abstract Nanotechnology is a vibrant and fast-developing field in science with diverse applications. Silver nanoparticles (AgNPs) are becoming gradually valuable because of their exceptional antimicrobial properties and remarkable physical characteristics. This study reports the phytochemical screening of Allium jacquemontii plant extract for the preparation of AgNPs. The prepared nanoparticles (NPs) were characterized via UV- spectroscopy, X-ray diffraction analysis (XRD), scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) spectroscopy, and transmission electron microscopy (TEM) and were evaluated for antimicrobial and pharmacological activities. HPLC analysis showed that A. jacquemontii had the lowest quantity of ferulic acid (10.3 ppm) and the highest concentration of chlorogenic acid (317.9 ppm). The prepared AgNPs exhibited excellent antifungal potential against Aspergillus niger, with maximum growth inhibition of 64.4% while strong antibacterial activity of 14.3 mm against Escherichia coli at a dose of 10 mg/ml was found. Similarly, the highest antiparasitic activity was 75.41 ± 1.16 against Promastigote and 71.13 ± 0.12 against Amastigote at 200 µg/mg. Inhibition of glucosidase, and amylase was observed, suggesting potential antidiabetic properties. The AgNPs were found to be biofriendly with red blood cells (RBCs) of a healthy human. This study indicates the potential of A. jacquemontii inflorescence derived AgNPs. |
| format | Article |
| id | doaj-art-963daee990d8404f92a8f1386d041740 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-963daee990d8404f92a8f1386d0417402025-08-20T04:02:46ZengNature PortfolioScientific Reports2045-23222025-07-0115111210.1038/s41598-025-10828-yBiogenic synthesis of silver nanoparticles (AgNPs) from Allium jacquemontii extract and its assessment in different biological activitiesAsif Kamal0Moona Nazish1Tehmina Siddique2Muhammad Azhar Khan3Narjis Khatoon4Ghulam Mujtaba Shah5Jawaher Alzahrani6Wasim Akhtar7Shoaib Noor8Muhammad Tahir Naseem9Wajid Zaman10Department of Plant Sciences, Faculty of Biological Sciences, Quaid-I-Azam University Department of Plant Sciences, Faculty of Biological Sciences, Quaid-I-Azam University Govt. Sadiq College Women UniversityDepartment of Botany, Hazara UniversityCenter of Agricultural Biochemistry and Biotechnology, University of AgricultureDepartment of Botany, Hazara UniversityDepartment of Zoology, College of Science, King Saud UniversityDepartment of Botany, University of Azad Jammu and KashmirDepartment of Plant Sciences, Faculty of Biological Sciences, Quaid-I-Azam University Department of Electronic Engineering, Yeungnam UniversityDepartment of Electronic Engineering, Yeungnam UniversityAbstract Nanotechnology is a vibrant and fast-developing field in science with diverse applications. Silver nanoparticles (AgNPs) are becoming gradually valuable because of their exceptional antimicrobial properties and remarkable physical characteristics. This study reports the phytochemical screening of Allium jacquemontii plant extract for the preparation of AgNPs. The prepared nanoparticles (NPs) were characterized via UV- spectroscopy, X-ray diffraction analysis (XRD), scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) spectroscopy, and transmission electron microscopy (TEM) and were evaluated for antimicrobial and pharmacological activities. HPLC analysis showed that A. jacquemontii had the lowest quantity of ferulic acid (10.3 ppm) and the highest concentration of chlorogenic acid (317.9 ppm). The prepared AgNPs exhibited excellent antifungal potential against Aspergillus niger, with maximum growth inhibition of 64.4% while strong antibacterial activity of 14.3 mm against Escherichia coli at a dose of 10 mg/ml was found. Similarly, the highest antiparasitic activity was 75.41 ± 1.16 against Promastigote and 71.13 ± 0.12 against Amastigote at 200 µg/mg. Inhibition of glucosidase, and amylase was observed, suggesting potential antidiabetic properties. The AgNPs were found to be biofriendly with red blood cells (RBCs) of a healthy human. This study indicates the potential of A. jacquemontii inflorescence derived AgNPs.https://doi.org/10.1038/s41598-025-10828-yNanotechnologySilver nanoparticles (AgNPs)Allium jacquemontiiHPLC analysisBiological activities |
| spellingShingle | Asif Kamal Moona Nazish Tehmina Siddique Muhammad Azhar Khan Narjis Khatoon Ghulam Mujtaba Shah Jawaher Alzahrani Wasim Akhtar Shoaib Noor Muhammad Tahir Naseem Wajid Zaman Biogenic synthesis of silver nanoparticles (AgNPs) from Allium jacquemontii extract and its assessment in different biological activities Scientific Reports Nanotechnology Silver nanoparticles (AgNPs) Allium jacquemontii HPLC analysis Biological activities |
| title | Biogenic synthesis of silver nanoparticles (AgNPs) from Allium jacquemontii extract and its assessment in different biological activities |
| title_full | Biogenic synthesis of silver nanoparticles (AgNPs) from Allium jacquemontii extract and its assessment in different biological activities |
| title_fullStr | Biogenic synthesis of silver nanoparticles (AgNPs) from Allium jacquemontii extract and its assessment in different biological activities |
| title_full_unstemmed | Biogenic synthesis of silver nanoparticles (AgNPs) from Allium jacquemontii extract and its assessment in different biological activities |
| title_short | Biogenic synthesis of silver nanoparticles (AgNPs) from Allium jacquemontii extract and its assessment in different biological activities |
| title_sort | biogenic synthesis of silver nanoparticles agnps from allium jacquemontii extract and its assessment in different biological activities |
| topic | Nanotechnology Silver nanoparticles (AgNPs) Allium jacquemontii HPLC analysis Biological activities |
| url | https://doi.org/10.1038/s41598-025-10828-y |
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