CLOCK 3111T/C Variant Correlates with Motor Fluctuation and Sleep Disorders in Chinese Patients with Parkinson’s Disease
Background. The clock genes controlling biological rhythm play an important role in the pathophysiology of aging. The purpose of this study was to determine whether there is an association between a variant of the circadian locomotor output cycles kaput (CLOCK) gene and circadian dysfunction of Park...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2018/4670380 |
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| author | Fan Lou Ming Li Xiaoguang Luo Yan Ren |
| author_facet | Fan Lou Ming Li Xiaoguang Luo Yan Ren |
| author_sort | Fan Lou |
| collection | DOAJ |
| description | Background. The clock genes controlling biological rhythm play an important role in the pathophysiology of aging. The purpose of this study was to determine whether there is an association between a variant of the circadian locomotor output cycles kaput (CLOCK) gene and circadian dysfunction of Parkinson’s disease (PD). Methods. Six hundred and forty-six cases of Parkinson’s disease from consecutive outpatients and inpatients ward from our hospital were included in this study. Kompetitive allele-specific PCR was used to determine the frequency distribution of genotypes and alleles. The examinations for the PD group were assessed in person in order to evaluate motor symptoms, cognitive function, sleep, and depression, including the Unified Parkinson’s Disease Rating Scale (UPDRS), Mini-Mental State Examination (MMSE), Pittsburgh Sleep Quality Index (PSQI), and 17-item Hamilton Rating Scale for Depression (HAMD-17). Results. Motor fluctuation (P<0.001) and sleep disorders (P=0.007) were significantly different between the two groups. These correlations persisted after adjusting for confounding risk factors by further binary logistic regression analysis, suggesting that the CLOCK 3111T/C variant was associated with motor fluctuation (OR = 1.080, P<0.001) and a subjective sleep disorder (OR = 1.130, P=0.037). Conclusion. The CLOCK 3111T/C variant can be an independent risk factor for motor fluctuation and sleep disorder in Parkinson’s disease. |
| format | Article |
| id | doaj-art-963bdba67d844107b286c477e609036a |
| institution | OA Journals |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-963bdba67d844107b286c477e609036a2025-08-20T02:10:16ZengWileyParkinson's Disease2090-80832042-00802018-01-01201810.1155/2018/46703804670380CLOCK 3111T/C Variant Correlates with Motor Fluctuation and Sleep Disorders in Chinese Patients with Parkinson’s DiseaseFan Lou0Ming Li1Xiaoguang Luo2Yan Ren3Department of Neurology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Neurology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Neurology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Neurology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, ChinaBackground. The clock genes controlling biological rhythm play an important role in the pathophysiology of aging. The purpose of this study was to determine whether there is an association between a variant of the circadian locomotor output cycles kaput (CLOCK) gene and circadian dysfunction of Parkinson’s disease (PD). Methods. Six hundred and forty-six cases of Parkinson’s disease from consecutive outpatients and inpatients ward from our hospital were included in this study. Kompetitive allele-specific PCR was used to determine the frequency distribution of genotypes and alleles. The examinations for the PD group were assessed in person in order to evaluate motor symptoms, cognitive function, sleep, and depression, including the Unified Parkinson’s Disease Rating Scale (UPDRS), Mini-Mental State Examination (MMSE), Pittsburgh Sleep Quality Index (PSQI), and 17-item Hamilton Rating Scale for Depression (HAMD-17). Results. Motor fluctuation (P<0.001) and sleep disorders (P=0.007) were significantly different between the two groups. These correlations persisted after adjusting for confounding risk factors by further binary logistic regression analysis, suggesting that the CLOCK 3111T/C variant was associated with motor fluctuation (OR = 1.080, P<0.001) and a subjective sleep disorder (OR = 1.130, P=0.037). Conclusion. The CLOCK 3111T/C variant can be an independent risk factor for motor fluctuation and sleep disorder in Parkinson’s disease.http://dx.doi.org/10.1155/2018/4670380 |
| spellingShingle | Fan Lou Ming Li Xiaoguang Luo Yan Ren CLOCK 3111T/C Variant Correlates with Motor Fluctuation and Sleep Disorders in Chinese Patients with Parkinson’s Disease Parkinson's Disease |
| title | CLOCK 3111T/C Variant Correlates with Motor Fluctuation and Sleep Disorders in Chinese Patients with Parkinson’s Disease |
| title_full | CLOCK 3111T/C Variant Correlates with Motor Fluctuation and Sleep Disorders in Chinese Patients with Parkinson’s Disease |
| title_fullStr | CLOCK 3111T/C Variant Correlates with Motor Fluctuation and Sleep Disorders in Chinese Patients with Parkinson’s Disease |
| title_full_unstemmed | CLOCK 3111T/C Variant Correlates with Motor Fluctuation and Sleep Disorders in Chinese Patients with Parkinson’s Disease |
| title_short | CLOCK 3111T/C Variant Correlates with Motor Fluctuation and Sleep Disorders in Chinese Patients with Parkinson’s Disease |
| title_sort | clock 3111t c variant correlates with motor fluctuation and sleep disorders in chinese patients with parkinson s disease |
| url | http://dx.doi.org/10.1155/2018/4670380 |
| work_keys_str_mv | AT fanlou clock3111tcvariantcorrelateswithmotorfluctuationandsleepdisordersinchinesepatientswithparkinsonsdisease AT mingli clock3111tcvariantcorrelateswithmotorfluctuationandsleepdisordersinchinesepatientswithparkinsonsdisease AT xiaoguangluo clock3111tcvariantcorrelateswithmotorfluctuationandsleepdisordersinchinesepatientswithparkinsonsdisease AT yanren clock3111tcvariantcorrelateswithmotorfluctuationandsleepdisordersinchinesepatientswithparkinsonsdisease |