Glaucoma and brain functional networks: a bidirectional Mendelian randomisation study
Objective Glaucoma is a complex neurodegenerative ocular disorder accompanied by brain functional abnormalities that extend beyond the visual system. However, the causal association between the two remains unclear at present. This study aimed to investigate the potential causal relationships between...
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BMJ Publishing Group
2025-04-01
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| Series: | BMJ Open Ophthalmology |
| Online Access: | https://bmjophth.bmj.com/content/10/1/e001902.full |
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| author | Xiaoxiao Chen Xinghuai Sun Lian Shu |
| author_facet | Xiaoxiao Chen Xinghuai Sun Lian Shu |
| author_sort | Xiaoxiao Chen |
| collection | DOAJ |
| description | Objective Glaucoma is a complex neurodegenerative ocular disorder accompanied by brain functional abnormalities that extend beyond the visual system. However, the causal association between the two remains unclear at present. This study aimed to investigate the potential causal relationships between glaucoma and brain functional networks in order to provide novel insights into the neuropathic mechanism of glaucoma.Methods and analysis Based on the genome-wide association studies data of glaucoma and resting-state functional MRI (Rs-fMRI), a bidirectional Mendelian randomisation (MR) analysis was conducted between glaucoma and brain functional networks. Inverse variance weighting was applied as the primary method to estimate causality with false discovery rate correction. Additional sensitivity analyses were conducted to evaluate the robustness of the results.Results Forward MR analysis suggested that glaucoma was causally associated with two brain networks between the subcortical cerebellum and the attention or visual network (p=0.022), as well as the default mode and central executive network (p=0.008), but without significance after false discovery rate correction (q>0.1). Reverse MR analysis revealed 19 Rs-fMRI traits related to glaucoma risk, including the salience or central executive network in the frontal region (p=0.0005, q=0.08) and the motor network (p=0.0009, q=0.08) with significant causality.Conclusions This MR study revealed potentially causal relationships between glaucoma and brain functional networks. Especially, the functional connectivity of the motor network between the postcentral or precentral areas may potentially lead to increased risk of glaucoma. |
| format | Article |
| id | doaj-art-963b4f80c2f5403a8de8d88a0f7fda18 |
| institution | OA Journals |
| issn | 2397-3269 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Ophthalmology |
| spelling | doaj-art-963b4f80c2f5403a8de8d88a0f7fda182025-08-20T02:09:45ZengBMJ Publishing GroupBMJ Open Ophthalmology2397-32692025-04-0110110.1136/bmjophth-2024-001902Glaucoma and brain functional networks: a bidirectional Mendelian randomisation studyXiaoxiao Chen0Xinghuai Sun1Lian Shu2Fudan University Eye Ear Nose and Throat Hospital Department of Ophthalmology, Shanghai, ChinaDepartment of Ophthalmology & Visual Science, Fudan University Eye Ear Nose and Throat Hospital, Shanghai, ChinaFudan University Eye Ear Nose and Throat Hospital Department of Ophthalmology, Shanghai, ChinaObjective Glaucoma is a complex neurodegenerative ocular disorder accompanied by brain functional abnormalities that extend beyond the visual system. However, the causal association between the two remains unclear at present. This study aimed to investigate the potential causal relationships between glaucoma and brain functional networks in order to provide novel insights into the neuropathic mechanism of glaucoma.Methods and analysis Based on the genome-wide association studies data of glaucoma and resting-state functional MRI (Rs-fMRI), a bidirectional Mendelian randomisation (MR) analysis was conducted between glaucoma and brain functional networks. Inverse variance weighting was applied as the primary method to estimate causality with false discovery rate correction. Additional sensitivity analyses were conducted to evaluate the robustness of the results.Results Forward MR analysis suggested that glaucoma was causally associated with two brain networks between the subcortical cerebellum and the attention or visual network (p=0.022), as well as the default mode and central executive network (p=0.008), but without significance after false discovery rate correction (q>0.1). Reverse MR analysis revealed 19 Rs-fMRI traits related to glaucoma risk, including the salience or central executive network in the frontal region (p=0.0005, q=0.08) and the motor network (p=0.0009, q=0.08) with significant causality.Conclusions This MR study revealed potentially causal relationships between glaucoma and brain functional networks. Especially, the functional connectivity of the motor network between the postcentral or precentral areas may potentially lead to increased risk of glaucoma.https://bmjophth.bmj.com/content/10/1/e001902.full |
| spellingShingle | Xiaoxiao Chen Xinghuai Sun Lian Shu Glaucoma and brain functional networks: a bidirectional Mendelian randomisation study BMJ Open Ophthalmology |
| title | Glaucoma and brain functional networks: a bidirectional Mendelian randomisation study |
| title_full | Glaucoma and brain functional networks: a bidirectional Mendelian randomisation study |
| title_fullStr | Glaucoma and brain functional networks: a bidirectional Mendelian randomisation study |
| title_full_unstemmed | Glaucoma and brain functional networks: a bidirectional Mendelian randomisation study |
| title_short | Glaucoma and brain functional networks: a bidirectional Mendelian randomisation study |
| title_sort | glaucoma and brain functional networks a bidirectional mendelian randomisation study |
| url | https://bmjophth.bmj.com/content/10/1/e001902.full |
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