Magnesium-based nanocomposites for orthopedic applications: A review
Mg-based materials have potential applications in the field of orthopedics owing to their good biodegradability, biocompatibility, and bone-inducing properties. However, during the early application process, their major drawback was rapid degradation rate, which limited their clinical application. N...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-11-01
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| Series: | Journal of Magnesium and Alloys |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213956724003839 |
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| author | Meng Cheng Xigang Liang Lihua Cui Dongyan Guan Yang Qu Jianwu Zhao Kai Guan |
| author_facet | Meng Cheng Xigang Liang Lihua Cui Dongyan Guan Yang Qu Jianwu Zhao Kai Guan |
| author_sort | Meng Cheng |
| collection | DOAJ |
| description | Mg-based materials have potential applications in the field of orthopedics owing to their good biodegradability, biocompatibility, and bone-inducing properties. However, during the early application process, their major drawback was rapid degradation rate, which limited their clinical application. Nanoparticles can effectively reinforce the mechanical strength and corrosion resistance of Mg matrices, and different nanoparticles can be selected to achieve different biological functions. Therefore, Mg-based nanocomposites have emerged as a versatile class of degradable implant materials with broad clinical potential. This review summarizes the research progress of Mg-based orthopedic implants, mainly including the reinforcement mechanism of nanoparticles on Mg-based materials, the effects and biological functions of different nanoparticle enhancers, surface modification, and the application of new manufacturing technologies. Furthermore, the degradation process of Mg-based materials and the biological functions of magnesium ion (Mg2+) during the degradation process are discussed in detail. We focused on the biological mechanisms through which Mg2+ promotes bone and vascular formation and inhibits osteoclasts by regulating the immune microenvironment or multiple signaling pathways. Finally, the clinical application of Mg-based orthopedic implants are introduced and the future research directions of Mg-based nanocomposites are discussed. |
| format | Article |
| id | doaj-art-9637a3c37bf94f52a09be6ecca20b182 |
| institution | Kabale University |
| issn | 2213-9567 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Journal of Magnesium and Alloys |
| spelling | doaj-art-9637a3c37bf94f52a09be6ecca20b1822025-01-05T04:28:05ZengKeAi Communications Co., Ltd.Journal of Magnesium and Alloys2213-95672024-11-01121143354362Magnesium-based nanocomposites for orthopedic applications: A reviewMeng Cheng0Xigang Liang1Lihua Cui2Dongyan Guan3Yang Qu4Jianwu Zhao5Kai Guan6Department of Orthopedics, The Second Hospital of Jilin University, Changchun, Jilin Province, 130014, P. R. ChinaDepartment of Orthopedics, Binzhou People's Hospital, Binzhou, Shandong Province 256610, P. R. ChinaDepartment of Orthopedics, Binzhou People's Hospital, Binzhou, Shandong Province 256610, P. R. ChinaDepartment of Operating Theatre, Liangshan People's Hospital, Liangshan, Shandong Province 272600, P. R. China; Corresponding authors.Department of Orthopedics, The Second Hospital of Jilin University, Changchun, Jilin Province, 130014, P. R. ChinaDepartment of Orthopedics, The Second Hospital of Jilin University, Changchun, Jilin Province, 130014, P. R. China; Corresponding authors.Key Laboratory of Automobile Materials of Ministry of Education & School of Materials Science and Engineering, Jilin University, Changchun, Jilin Province, 130025, P. R. China; International Center of Future Science, Jilin University, Changchun, Jilin Province, 130025, P. R. China; Corresponding authors.Mg-based materials have potential applications in the field of orthopedics owing to their good biodegradability, biocompatibility, and bone-inducing properties. However, during the early application process, their major drawback was rapid degradation rate, which limited their clinical application. Nanoparticles can effectively reinforce the mechanical strength and corrosion resistance of Mg matrices, and different nanoparticles can be selected to achieve different biological functions. Therefore, Mg-based nanocomposites have emerged as a versatile class of degradable implant materials with broad clinical potential. This review summarizes the research progress of Mg-based orthopedic implants, mainly including the reinforcement mechanism of nanoparticles on Mg-based materials, the effects and biological functions of different nanoparticle enhancers, surface modification, and the application of new manufacturing technologies. Furthermore, the degradation process of Mg-based materials and the biological functions of magnesium ion (Mg2+) during the degradation process are discussed in detail. We focused on the biological mechanisms through which Mg2+ promotes bone and vascular formation and inhibits osteoclasts by regulating the immune microenvironment or multiple signaling pathways. Finally, the clinical application of Mg-based orthopedic implants are introduced and the future research directions of Mg-based nanocomposites are discussed.http://www.sciencedirect.com/science/article/pii/S2213956724003839Magnesium-based nanocompositeStrengthening strategyMg2+Biodegradable materialOsteogenesis |
| spellingShingle | Meng Cheng Xigang Liang Lihua Cui Dongyan Guan Yang Qu Jianwu Zhao Kai Guan Magnesium-based nanocomposites for orthopedic applications: A review Journal of Magnesium and Alloys Magnesium-based nanocomposite Strengthening strategy Mg2+ Biodegradable material Osteogenesis |
| title | Magnesium-based nanocomposites for orthopedic applications: A review |
| title_full | Magnesium-based nanocomposites for orthopedic applications: A review |
| title_fullStr | Magnesium-based nanocomposites for orthopedic applications: A review |
| title_full_unstemmed | Magnesium-based nanocomposites for orthopedic applications: A review |
| title_short | Magnesium-based nanocomposites for orthopedic applications: A review |
| title_sort | magnesium based nanocomposites for orthopedic applications a review |
| topic | Magnesium-based nanocomposite Strengthening strategy Mg2+ Biodegradable material Osteogenesis |
| url | http://www.sciencedirect.com/science/article/pii/S2213956724003839 |
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