Diabetic Retinopathy: Vascular and Inflammatory Disease
Diabetic retinopathy (DR) is the leading cause of visual impairment in the working-age population of the Western world. The pathogenesis of DR is complex and several vascular, inflammatory, and neuronal mechanisms are involved. Inflammation mediates structural and molecular alterations associated wi...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/582060 |
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| author | F. Semeraro A. Cancarini R. dell’Omo S. Rezzola M. R. Romano C. Costagliola |
| author_facet | F. Semeraro A. Cancarini R. dell’Omo S. Rezzola M. R. Romano C. Costagliola |
| author_sort | F. Semeraro |
| collection | DOAJ |
| description | Diabetic retinopathy (DR) is the leading cause of visual impairment in the working-age population of the Western world. The pathogenesis of DR is complex and several vascular, inflammatory, and neuronal mechanisms are involved. Inflammation mediates structural and molecular alterations associated with DR. However, the molecular mechanisms underlying the inflammatory pathways associated with DR are not completely characterized. Previous studies indicate that tissue hypoxia and dysregulation of immune responses associated with diabetes mellitus can induce increased expression of numerous vitreous mediators responsible for DR development. Thus, analysis of vitreous humor obtained from diabetic patients has made it possible to identify some of the mediators (cytokines, chemokines, and other factors) responsible for DR pathogenesis. Further studies are needed to better understand the relationship between inflammation and DR. Herein the main vitreous-related factors triggering the occurrence of retinal complication in diabetes are highlighted. |
| format | Article |
| id | doaj-art-9636f47c529a4bfc89d04aa5cff66db3 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-9636f47c529a4bfc89d04aa5cff66db32025-08-20T03:37:30ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/582060582060Diabetic Retinopathy: Vascular and Inflammatory DiseaseF. Semeraro0A. Cancarini1R. dell’Omo2S. Rezzola3M. R. Romano4C. Costagliola5Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, ItalyDepartment of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, ItalyDepartment of Medicine and Health Sciences, University of Molise, Campobasso, ItalyDepartment of Molecular and Translational Medicine, University of Brescia, Brescia, ItalyDepartment of Neuroscience, Reproductive Sciences and Dentistry, University of Naples, ItalyDepartment of Medicine and Health Sciences, University of Molise, Campobasso, ItalyDiabetic retinopathy (DR) is the leading cause of visual impairment in the working-age population of the Western world. The pathogenesis of DR is complex and several vascular, inflammatory, and neuronal mechanisms are involved. Inflammation mediates structural and molecular alterations associated with DR. However, the molecular mechanisms underlying the inflammatory pathways associated with DR are not completely characterized. Previous studies indicate that tissue hypoxia and dysregulation of immune responses associated with diabetes mellitus can induce increased expression of numerous vitreous mediators responsible for DR development. Thus, analysis of vitreous humor obtained from diabetic patients has made it possible to identify some of the mediators (cytokines, chemokines, and other factors) responsible for DR pathogenesis. Further studies are needed to better understand the relationship between inflammation and DR. Herein the main vitreous-related factors triggering the occurrence of retinal complication in diabetes are highlighted.http://dx.doi.org/10.1155/2015/582060 |
| spellingShingle | F. Semeraro A. Cancarini R. dell’Omo S. Rezzola M. R. Romano C. Costagliola Diabetic Retinopathy: Vascular and Inflammatory Disease Journal of Diabetes Research |
| title | Diabetic Retinopathy: Vascular and Inflammatory Disease |
| title_full | Diabetic Retinopathy: Vascular and Inflammatory Disease |
| title_fullStr | Diabetic Retinopathy: Vascular and Inflammatory Disease |
| title_full_unstemmed | Diabetic Retinopathy: Vascular and Inflammatory Disease |
| title_short | Diabetic Retinopathy: Vascular and Inflammatory Disease |
| title_sort | diabetic retinopathy vascular and inflammatory disease |
| url | http://dx.doi.org/10.1155/2015/582060 |
| work_keys_str_mv | AT fsemeraro diabeticretinopathyvascularandinflammatorydisease AT acancarini diabeticretinopathyvascularandinflammatorydisease AT rdellomo diabeticretinopathyvascularandinflammatorydisease AT srezzola diabeticretinopathyvascularandinflammatorydisease AT mrromano diabeticretinopathyvascularandinflammatorydisease AT ccostagliola diabeticretinopathyvascularandinflammatorydisease |