Negative Histology after Endoscopic Resection: An Endoscopist’s Aspect
Endoscopic submucosal dissection (ESD) is accepted as the standard treatment for gastric epithelial dysplasia or early gastric cancer because it enables curative en bloc resection and complete histopathological assessment of the specimen. However, occasionally, a tumorous lesion may not be detected,...
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| Format: | Article |
| Language: | English |
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Korean College of Helicobacter and Upper Gastrointestinal Research
2018-03-01
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| Series: | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
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| Online Access: | http://www.helicojournal.org/journal/view.html?doi=10.7704/kjhugr.2018.18.1.17 |
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| author | Sung Jae Shin Min Jae Yang Choong-Kyun Noh Sun Gyo Lim Kee Myung Lee Kwang Jae Lee |
| author_facet | Sung Jae Shin Min Jae Yang Choong-Kyun Noh Sun Gyo Lim Kee Myung Lee Kwang Jae Lee |
| author_sort | Sung Jae Shin |
| collection | DOAJ |
| description | Endoscopic submucosal dissection (ESD) is accepted as the standard treatment for gastric epithelial dysplasia or early gastric cancer because it enables curative en bloc resection and complete histopathological assessment of the specimen. However, occasionally, a tumorous lesion may not be detected, and histopathological discrepancies can occur after ESD. Reportedly, the prevalence of negative histopathological results after endoscopic resection is 2.0∼4.4%. Negative histopathological results after endoscopic resection are commonly attributable to complete removal of the lesion via an endoscopic forceps biopsy (EFB) at the time of the initial diagnostic endoscopic examination, an initial histopathological overestimation of the EFB specimen, and incorrect localization of the original tumor with subsequent ESD performed at a wrong site. A small tumor size and surface area are known to be significant endoscopic predictors of negative histopathological results after ESD. Therefore, clinicians should be mindful of the fact that negative histopathological findings observed after endoscopic resection warrant a comprehensive review of all pre-ESD data and an adequate follow-up to determine the cause of these findings and to detect any possibility of local recurrence. |
| format | Article |
| id | doaj-art-96355ba460904990874208a09d7e8b3f |
| institution | Kabale University |
| issn | 1738-3331 |
| language | English |
| publishDate | 2018-03-01 |
| publisher | Korean College of Helicobacter and Upper Gastrointestinal Research |
| record_format | Article |
| series | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
| spelling | doaj-art-96355ba460904990874208a09d7e8b3f2025-08-20T03:57:04ZengKorean College of Helicobacter and Upper Gastrointestinal ResearchThe Korean Journal of Helicobacter and Upper Gastrointestinal Research1738-33312018-03-01181172010.7704/kjhugr.2018.18.1.17kjhugr.2018.18.1.17Negative Histology after Endoscopic Resection: An Endoscopist’s AspectSung Jae Shin0Min Jae Yang1Choong-Kyun Noh2Sun Gyo Lim3Kee Myung Lee4Kwang Jae Lee5Division of Gastroenterology, Department of Internal Medicine, Ajou University Hospital, Ajou University School of Medicine, Suwon, KoreaDivision of Gastroenterology, Department of Internal Medicine, Ajou University Hospital, Ajou University School of Medicine, Suwon, KoreaDivision of Gastroenterology, Department of Internal Medicine, Ajou University Hospital, Ajou University School of Medicine, Suwon, KoreaDivision of Gastroenterology, Department of Internal Medicine, Ajou University Hospital, Ajou University School of Medicine, Suwon, KoreaDivision of Gastroenterology, Department of Internal Medicine, Ajou University Hospital, Ajou University School of Medicine, Suwon, KoreaDivision of Gastroenterology, Department of Internal Medicine, Ajou University Hospital, Ajou University School of Medicine, Suwon, KoreaEndoscopic submucosal dissection (ESD) is accepted as the standard treatment for gastric epithelial dysplasia or early gastric cancer because it enables curative en bloc resection and complete histopathological assessment of the specimen. However, occasionally, a tumorous lesion may not be detected, and histopathological discrepancies can occur after ESD. Reportedly, the prevalence of negative histopathological results after endoscopic resection is 2.0∼4.4%. Negative histopathological results after endoscopic resection are commonly attributable to complete removal of the lesion via an endoscopic forceps biopsy (EFB) at the time of the initial diagnostic endoscopic examination, an initial histopathological overestimation of the EFB specimen, and incorrect localization of the original tumor with subsequent ESD performed at a wrong site. A small tumor size and surface area are known to be significant endoscopic predictors of negative histopathological results after ESD. Therefore, clinicians should be mindful of the fact that negative histopathological findings observed after endoscopic resection warrant a comprehensive review of all pre-ESD data and an adequate follow-up to determine the cause of these findings and to detect any possibility of local recurrence.http://www.helicojournal.org/journal/view.html?doi=10.7704/kjhugr.2018.18.1.17Endoscopic resectionHistologyStomach neoplasms |
| spellingShingle | Sung Jae Shin Min Jae Yang Choong-Kyun Noh Sun Gyo Lim Kee Myung Lee Kwang Jae Lee Negative Histology after Endoscopic Resection: An Endoscopist’s Aspect The Korean Journal of Helicobacter and Upper Gastrointestinal Research Endoscopic resection Histology Stomach neoplasms |
| title | Negative Histology after Endoscopic Resection: An Endoscopist’s Aspect |
| title_full | Negative Histology after Endoscopic Resection: An Endoscopist’s Aspect |
| title_fullStr | Negative Histology after Endoscopic Resection: An Endoscopist’s Aspect |
| title_full_unstemmed | Negative Histology after Endoscopic Resection: An Endoscopist’s Aspect |
| title_short | Negative Histology after Endoscopic Resection: An Endoscopist’s Aspect |
| title_sort | negative histology after endoscopic resection an endoscopist s aspect |
| topic | Endoscopic resection Histology Stomach neoplasms |
| url | http://www.helicojournal.org/journal/view.html?doi=10.7704/kjhugr.2018.18.1.17 |
| work_keys_str_mv | AT sungjaeshin negativehistologyafterendoscopicresectionanendoscopistsaspect AT minjaeyang negativehistologyafterendoscopicresectionanendoscopistsaspect AT choongkyunnoh negativehistologyafterendoscopicresectionanendoscopistsaspect AT sungyolim negativehistologyafterendoscopicresectionanendoscopistsaspect AT keemyunglee negativehistologyafterendoscopicresectionanendoscopistsaspect AT kwangjaelee negativehistologyafterendoscopicresectionanendoscopistsaspect |