Clinical outcomes of continuous local antibiotic perfusion in combination with debridement antibiotics and implant retention for periprosthetic hip joint infection

Clinical outcomes of continuous local antibiotic perfusion in combination with debridement antibiotics and implant retention for periprosthetic hip joint infection

Abstract Periprosthetic joint infection (PJI) is a complication of peri-implant biofilm-based treatments and confers resistance to antimicrobial therapy. Integrating continuous local antibiotic perfusion (CLAP) with conventional surgery for PJI facilitates the local delivery of low-flow, high-concen...

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Bibliographic Details
Main Authors: Yuta Hieda, Hyonmin Choe, Akihiro Maruo, Koki Abe, Masashi Shimoda, Hiroyuki Ike, Ken Kumagai, Naomi Kobayashi, Yutaka Inaba
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Continuous local antibiotic perfusion
Debridement
Implant retention
Periprosthetic joint infection
Online Access:https://doi.org/10.1038/s41598-025-11808-y
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