PREGABALIN EFFECTS ON CELLULAR AND HUMORAL COMPONENTS OF BLOOD OF MICE (Mus musculus)
The oral use of pregabalin was evaluated in this study to reveal its effects on some hematological and biochemical parameters of laboratory mice. The animals of this study were divided into three groups (twelve mice each). The control group was fed on a standard ration. The first treated group (Preg...
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College of Veterinary Medicine, University of Basrah, Iraq
2017-12-01
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| Series: | Basrah Journal of Veterinary Research |
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| Online Access: | https://bjvr.uobasrah.edu.iq/article_143534_e20c33abde7fac45df2cecd3794ec850.pdf |
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| author | Wissam Sajid Hashim Al-Uboody |
| author_facet | Wissam Sajid Hashim Al-Uboody |
| author_sort | Wissam Sajid Hashim Al-Uboody |
| collection | DOAJ |
| description | The oral use of pregabalin was evaluated in this study to reveal its effects on some
hematological and biochemical parameters of laboratory mice. The animals of this
study were divided into three groups (twelve mice each). The control group was fed
on a standard ration. The first treated group (Pregabalin 1) were dosed orally with one
ml of distilled water containing Pregabalin (20 mg/ml/mice/ day). The second treated
group (Pregabalin 2) were dosed orally with one ml of distilled water containing
pregabalin (40mg/ml/mice/ day). The experiment continued for two successive
months. The results showed that the use of pregabalin caused a significant declination
in R.B.C., HGB, HCT, W.B.C., M.C.V., MCH, and MCHC of both treated groups
compared them with control group and the declination was more significant in
(pregabalin 2) group compared with (pregabalin 1) group. The RDW-CV, RDW-SD,
and PLT increased significantly in both treated groups as compared with those of the
control group. However, PCT, PDW and MPV were not affected by the use of
pregabalin except the MPV of (Pregabalin 2) group was significantly less than that of
(Pregabalin 1) but without a significant difference compared with that of control. The
Fe++, and GLU decreased significantly in both treated groups compared with the
control and they declined more significantly in (Pregabalin 2) compared with
(Pregabalin 1). Both the TP and Ca++ did not affected by the use of pregabalin
compared with the control group (P≤0.05) |
| format | Article |
| id | doaj-art-962fae0310e643daa40709718e614ea1 |
| institution | OA Journals |
| issn | 1813-8497 2410-8456 |
| language | English |
| publishDate | 2017-12-01 |
| publisher | College of Veterinary Medicine, University of Basrah, Iraq |
| record_format | Article |
| series | Basrah Journal of Veterinary Research |
| spelling | doaj-art-962fae0310e643daa40709718e614ea12025-08-20T02:30:50ZengCollege of Veterinary Medicine, University of Basrah, IraqBasrah Journal of Veterinary Research1813-84972410-84562017-12-01162768410.33762/bvetr.2017.143534143534PREGABALIN EFFECTS ON CELLULAR AND HUMORAL COMPONENTS OF BLOOD OF MICE (Mus musculus)Wissam Sajid Hashim Al-UboodyThe oral use of pregabalin was evaluated in this study to reveal its effects on some hematological and biochemical parameters of laboratory mice. The animals of this study were divided into three groups (twelve mice each). The control group was fed on a standard ration. The first treated group (Pregabalin 1) were dosed orally with one ml of distilled water containing Pregabalin (20 mg/ml/mice/ day). The second treated group (Pregabalin 2) were dosed orally with one ml of distilled water containing pregabalin (40mg/ml/mice/ day). The experiment continued for two successive months. The results showed that the use of pregabalin caused a significant declination in R.B.C., HGB, HCT, W.B.C., M.C.V., MCH, and MCHC of both treated groups compared them with control group and the declination was more significant in (pregabalin 2) group compared with (pregabalin 1) group. The RDW-CV, RDW-SD, and PLT increased significantly in both treated groups as compared with those of the control group. However, PCT, PDW and MPV were not affected by the use of pregabalin except the MPV of (Pregabalin 2) group was significantly less than that of (Pregabalin 1) but without a significant difference compared with that of control. The Fe++, and GLU decreased significantly in both treated groups compared with the control and they declined more significantly in (Pregabalin 2) compared with (Pregabalin 1). Both the TP and Ca++ did not affected by the use of pregabalin compared with the control group (P≤0.05)https://bjvr.uobasrah.edu.iq/article_143534_e20c33abde7fac45df2cecd3794ec850.pdfpregabalinelectrolytesmice |
| spellingShingle | Wissam Sajid Hashim Al-Uboody PREGABALIN EFFECTS ON CELLULAR AND HUMORAL COMPONENTS OF BLOOD OF MICE (Mus musculus) Basrah Journal of Veterinary Research pregabalin electrolytes mice |
| title | PREGABALIN EFFECTS ON CELLULAR AND HUMORAL COMPONENTS OF BLOOD OF MICE (Mus musculus) |
| title_full | PREGABALIN EFFECTS ON CELLULAR AND HUMORAL COMPONENTS OF BLOOD OF MICE (Mus musculus) |
| title_fullStr | PREGABALIN EFFECTS ON CELLULAR AND HUMORAL COMPONENTS OF BLOOD OF MICE (Mus musculus) |
| title_full_unstemmed | PREGABALIN EFFECTS ON CELLULAR AND HUMORAL COMPONENTS OF BLOOD OF MICE (Mus musculus) |
| title_short | PREGABALIN EFFECTS ON CELLULAR AND HUMORAL COMPONENTS OF BLOOD OF MICE (Mus musculus) |
| title_sort | pregabalin effects on cellular and humoral components of blood of mice mus musculus |
| topic | pregabalin electrolytes mice |
| url | https://bjvr.uobasrah.edu.iq/article_143534_e20c33abde7fac45df2cecd3794ec850.pdf |
| work_keys_str_mv | AT wissamsajidhashimaluboody pregabalineffectsoncellularandhumoralcomponentsofbloodofmicemusmusculus |