Association of Matrix Metalloproteinase 9 (MMP-9) Polymorphisms with Asthma Risk: A Meta-Analysis

Published data on the association between MMP-9 polymorphisms (−1562 C > T, rs3918242; Gln279Arg, rs17576 Arg668Gln, rs17577) and asthma susceptibility are inconclusive. To derive a more precise estimation of this association, a meta-analysis was performed. A literature search was conducted in Pu...

Full description

Saved in:
Bibliographic Details
Main Authors: Fenfang Zou, Jianpeng Zhang, Guoan Xiang, Hongbin Jiao, Hongmei Gao
Format: Article
Language:English
Published: Wiley 2019-01-01
Series:Canadian Respiratory Journal
Online Access:http://dx.doi.org/10.1155/2019/9260495
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832562890960273408
author Fenfang Zou
Jianpeng Zhang
Guoan Xiang
Hongbin Jiao
Hongmei Gao
author_facet Fenfang Zou
Jianpeng Zhang
Guoan Xiang
Hongbin Jiao
Hongmei Gao
author_sort Fenfang Zou
collection DOAJ
description Published data on the association between MMP-9 polymorphisms (−1562 C > T, rs3918242; Gln279Arg, rs17576 Arg668Gln, rs17577) and asthma susceptibility are inconclusive. To derive a more precise estimation of this association, a meta-analysis was performed. A literature search was conducted in PubMed, Web of Science, EMBASE, Wanfang, and China National Knowledge Infrastructure (CNKI) databases to identify eligible studies. The pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were used to calculate the strength of association. Sensitivity analysis was performed to evaluate the influence of individual studies on the overall effect estimates, and funnel plots and Egger’s test were inspected for indication of publication bias. Seven studies with 1592 asthma patients and 1987 controls were finally identified. Overall, we found no significant association between −1562 C > T, rs3918242 polymorphism, and asthma susceptibility in any of the genetic model comparisons. After categorizing studies into different subgroups on the basis of ethnicity and age, there is still no significant association. For the Gln279Arg, rs17576 polymorphism, there seems to be a significant association in the allelic genetic model in regard to the P value (OR = 1.11, 95% CI = 1.00–1.22, I2 = 0%, PZ=0.044); however, the value of lower 95% CI is 1.0. For the Arg668Gln, rs17577 polymorphism, a high significant association was observed in the dominant model comparison (OR = 1.65, 95% CI = 1.28–2.11, I2 = 22.50%, PZ=0), recessive model comparison (OR = 2.40, 95% CI = 1.23–4.72, I2 = 0%, PZ=0.011), homozygote genotype comparison (OR = 2.69, 95% CI = 1.36–5.33, I2 = 0%, PZ=0.004), and allelic genetic model (OR = 1.59, 95% CI = 1.29–1.97, I2 = 36.9%, PZ=0). Sensitivity analysis demonstrated the stability of our results, and publication bias was not evident. The present meta-analysis suggests that MMP-9 Arg668Gln, rs17577 polymorphism may be the risk factor for asthma susceptibility.
format Article
id doaj-art-962f64c58c9940049b88ebbac0209ef0
institution Kabale University
issn 1198-2241
1916-7245
language English
publishDate 2019-01-01
publisher Wiley
record_format Article
series Canadian Respiratory Journal
spelling doaj-art-962f64c58c9940049b88ebbac0209ef02025-02-03T01:21:29ZengWileyCanadian Respiratory Journal1198-22411916-72452019-01-01201910.1155/2019/92604959260495Association of Matrix Metalloproteinase 9 (MMP-9) Polymorphisms with Asthma Risk: A Meta-AnalysisFenfang Zou0Jianpeng Zhang1Guoan Xiang2Hongbin Jiao3Hongmei Gao4Department of Respiratory, The Third Medical Center of Chinese People’s Liberation Army General Hospital, Beijing, ChinaDepartment of Respiratory, The Third Medical Center of Chinese People’s Liberation Army General Hospital, Beijing, ChinaDepartment of Respiratory, The Third Medical Center of Chinese People’s Liberation Army General Hospital, Beijing, ChinaDepartment of Respiratory, The Third Medical Center of Chinese People’s Liberation Army General Hospital, Beijing, ChinaDepartment of Respiratory, The Third Medical Center of Chinese People’s Liberation Army General Hospital, Beijing, ChinaPublished data on the association between MMP-9 polymorphisms (−1562 C > T, rs3918242; Gln279Arg, rs17576 Arg668Gln, rs17577) and asthma susceptibility are inconclusive. To derive a more precise estimation of this association, a meta-analysis was performed. A literature search was conducted in PubMed, Web of Science, EMBASE, Wanfang, and China National Knowledge Infrastructure (CNKI) databases to identify eligible studies. The pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were used to calculate the strength of association. Sensitivity analysis was performed to evaluate the influence of individual studies on the overall effect estimates, and funnel plots and Egger’s test were inspected for indication of publication bias. Seven studies with 1592 asthma patients and 1987 controls were finally identified. Overall, we found no significant association between −1562 C > T, rs3918242 polymorphism, and asthma susceptibility in any of the genetic model comparisons. After categorizing studies into different subgroups on the basis of ethnicity and age, there is still no significant association. For the Gln279Arg, rs17576 polymorphism, there seems to be a significant association in the allelic genetic model in regard to the P value (OR = 1.11, 95% CI = 1.00–1.22, I2 = 0%, PZ=0.044); however, the value of lower 95% CI is 1.0. For the Arg668Gln, rs17577 polymorphism, a high significant association was observed in the dominant model comparison (OR = 1.65, 95% CI = 1.28–2.11, I2 = 22.50%, PZ=0), recessive model comparison (OR = 2.40, 95% CI = 1.23–4.72, I2 = 0%, PZ=0.011), homozygote genotype comparison (OR = 2.69, 95% CI = 1.36–5.33, I2 = 0%, PZ=0.004), and allelic genetic model (OR = 1.59, 95% CI = 1.29–1.97, I2 = 36.9%, PZ=0). Sensitivity analysis demonstrated the stability of our results, and publication bias was not evident. The present meta-analysis suggests that MMP-9 Arg668Gln, rs17577 polymorphism may be the risk factor for asthma susceptibility.http://dx.doi.org/10.1155/2019/9260495
spellingShingle Fenfang Zou
Jianpeng Zhang
Guoan Xiang
Hongbin Jiao
Hongmei Gao
Association of Matrix Metalloproteinase 9 (MMP-9) Polymorphisms with Asthma Risk: A Meta-Analysis
Canadian Respiratory Journal
title Association of Matrix Metalloproteinase 9 (MMP-9) Polymorphisms with Asthma Risk: A Meta-Analysis
title_full Association of Matrix Metalloproteinase 9 (MMP-9) Polymorphisms with Asthma Risk: A Meta-Analysis
title_fullStr Association of Matrix Metalloproteinase 9 (MMP-9) Polymorphisms with Asthma Risk: A Meta-Analysis
title_full_unstemmed Association of Matrix Metalloproteinase 9 (MMP-9) Polymorphisms with Asthma Risk: A Meta-Analysis
title_short Association of Matrix Metalloproteinase 9 (MMP-9) Polymorphisms with Asthma Risk: A Meta-Analysis
title_sort association of matrix metalloproteinase 9 mmp 9 polymorphisms with asthma risk a meta analysis
url http://dx.doi.org/10.1155/2019/9260495
work_keys_str_mv AT fenfangzou associationofmatrixmetalloproteinase9mmp9polymorphismswithasthmariskametaanalysis
AT jianpengzhang associationofmatrixmetalloproteinase9mmp9polymorphismswithasthmariskametaanalysis
AT guoanxiang associationofmatrixmetalloproteinase9mmp9polymorphismswithasthmariskametaanalysis
AT hongbinjiao associationofmatrixmetalloproteinase9mmp9polymorphismswithasthmariskametaanalysis
AT hongmeigao associationofmatrixmetalloproteinase9mmp9polymorphismswithasthmariskametaanalysis