Rabies seropositive individuals, dogs, and healthcare professionals without prior vaccination in four Brazilian Indigenous communities.
Indigenous communities are reportedly among the most vulnerable populations exposed to rabies worldwide. Accordingly, this study aimed to assess rabies serum titers from healthy Indigenous individuals, their dogs, and healthcare professionals of four Indigenous communities from São Paulo state, sout...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://doi.org/10.1371/journal.pntd.0012850 |
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| author | Matheus Lopes Ribeiro Camila Michele Appolinario Bruna Letícia Devidé Ribeiro João Henrique Farinhas Fernando Rodrigo Doline Gisely Toledo Barone Juliana Amorim Conselheiro Vamilton Alvarés Santarém Leandro Meneguelli Biondo Andrea Pires Dos Santos Rogério Giuffrida Louise Bach Kmetiuk Alexander Welker Biondo Jane Megid |
| author_facet | Matheus Lopes Ribeiro Camila Michele Appolinario Bruna Letícia Devidé Ribeiro João Henrique Farinhas Fernando Rodrigo Doline Gisely Toledo Barone Juliana Amorim Conselheiro Vamilton Alvarés Santarém Leandro Meneguelli Biondo Andrea Pires Dos Santos Rogério Giuffrida Louise Bach Kmetiuk Alexander Welker Biondo Jane Megid |
| author_sort | Matheus Lopes Ribeiro |
| collection | DOAJ |
| description | Indigenous communities are reportedly among the most vulnerable populations exposed to rabies worldwide. Accordingly, this study aimed to assess rabies serum titers from healthy Indigenous individuals, their dogs, and healthcare professionals of four Indigenous communities from São Paulo state, southeastern Brazil. Blood samples were collected, and an epidemiological questionnaire applied. The samples were processed by Fluorescent Antibody Virus Neutralization (FAVN) method. Overall, 35/299 (11.7%) individuals and 22/166 (13.2%) dogs without prior vaccination were seropositive. Furthermore, 4/18 (16.7%) healthcare professionals were seropositive, with only one reporting prior rabies vaccination. The lack of rabies titers in the remaining 14/18 (77.8%) healthcare professionals indicates no immune protection. Seropositivity was associated with being from the Kopenoty community (p = 0.026) and with owners reporting seeing their dogs in contact with bats (p = 0.022). In summary, these results should be considered as a warning for the risk of human-dog rabies exposure and infection, mainly due to bat contact. |
| format | Article |
| id | doaj-art-962f5a8097e44336803d1a1fe84befa4 |
| institution | Kabale University |
| issn | 1935-2727 1935-2735 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj-art-962f5a8097e44336803d1a1fe84befa42025-02-12T05:31:21ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352025-01-01191e001285010.1371/journal.pntd.0012850Rabies seropositive individuals, dogs, and healthcare professionals without prior vaccination in four Brazilian Indigenous communities.Matheus Lopes RibeiroCamila Michele AppolinarioBruna Letícia Devidé RibeiroJoão Henrique FarinhasFernando Rodrigo DolineGisely Toledo BaroneJuliana Amorim ConselheiroVamilton Alvarés SantarémLeandro Meneguelli BiondoAndrea Pires Dos SantosRogério GiuffridaLouise Bach KmetiukAlexander Welker BiondoJane MegidIndigenous communities are reportedly among the most vulnerable populations exposed to rabies worldwide. Accordingly, this study aimed to assess rabies serum titers from healthy Indigenous individuals, their dogs, and healthcare professionals of four Indigenous communities from São Paulo state, southeastern Brazil. Blood samples were collected, and an epidemiological questionnaire applied. The samples were processed by Fluorescent Antibody Virus Neutralization (FAVN) method. Overall, 35/299 (11.7%) individuals and 22/166 (13.2%) dogs without prior vaccination were seropositive. Furthermore, 4/18 (16.7%) healthcare professionals were seropositive, with only one reporting prior rabies vaccination. The lack of rabies titers in the remaining 14/18 (77.8%) healthcare professionals indicates no immune protection. Seropositivity was associated with being from the Kopenoty community (p = 0.026) and with owners reporting seeing their dogs in contact with bats (p = 0.022). In summary, these results should be considered as a warning for the risk of human-dog rabies exposure and infection, mainly due to bat contact.https://doi.org/10.1371/journal.pntd.0012850 |
| spellingShingle | Matheus Lopes Ribeiro Camila Michele Appolinario Bruna Letícia Devidé Ribeiro João Henrique Farinhas Fernando Rodrigo Doline Gisely Toledo Barone Juliana Amorim Conselheiro Vamilton Alvarés Santarém Leandro Meneguelli Biondo Andrea Pires Dos Santos Rogério Giuffrida Louise Bach Kmetiuk Alexander Welker Biondo Jane Megid Rabies seropositive individuals, dogs, and healthcare professionals without prior vaccination in four Brazilian Indigenous communities. PLoS Neglected Tropical Diseases |
| title | Rabies seropositive individuals, dogs, and healthcare professionals without prior vaccination in four Brazilian Indigenous communities. |
| title_full | Rabies seropositive individuals, dogs, and healthcare professionals without prior vaccination in four Brazilian Indigenous communities. |
| title_fullStr | Rabies seropositive individuals, dogs, and healthcare professionals without prior vaccination in four Brazilian Indigenous communities. |
| title_full_unstemmed | Rabies seropositive individuals, dogs, and healthcare professionals without prior vaccination in four Brazilian Indigenous communities. |
| title_short | Rabies seropositive individuals, dogs, and healthcare professionals without prior vaccination in four Brazilian Indigenous communities. |
| title_sort | rabies seropositive individuals dogs and healthcare professionals without prior vaccination in four brazilian indigenous communities |
| url | https://doi.org/10.1371/journal.pntd.0012850 |
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