Metabolomic and microbial insights: Kai-Xin-San’s impact on Alzheimer’s disease pathology
Summary: There has been increasing interest in the connection between AD, gut microbiota, and metabolites. Kai-Xin-San (KXS) has been commonly employed in ancient and modern Chinese clinical trials for the treatment of dementia; however, whether the protective effect of KXS in AD is related to the g...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-07-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225010788 |
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| author | Huifen Ma Zhiyang Yu Qiong Qiao Wenpan Wang Zhonghua Li Pan Wang Junying Song Xiaowei Zhang Yunfang Su Yiran Sun Zhishen Xie Zhenqiang Zhang |
| author_facet | Huifen Ma Zhiyang Yu Qiong Qiao Wenpan Wang Zhonghua Li Pan Wang Junying Song Xiaowei Zhang Yunfang Su Yiran Sun Zhishen Xie Zhenqiang Zhang |
| author_sort | Huifen Ma |
| collection | DOAJ |
| description | Summary: There has been increasing interest in the connection between AD, gut microbiota, and metabolites. Kai-Xin-San (KXS) has been commonly employed in ancient and modern Chinese clinical trials for the treatment of dementia; however, whether the protective effect of KXS in AD is related to the gut microbiota remains elusive. APP/PS1 mice were used as the model of AD. 43 key metabolites influenced by KXS were screened using untargeted metabolomics. At the genus level, Clostridium_IV, Eubacterium, Acetatifactor, etc., were identified to be impacted by KXS using 16S rRNA sequencing. Additionally, we identified 9 distinct intestinal floras at the genus level that were correlated with 13 pivotal differential metabolites related to cognitive impairment. KXS also inhibited the neuroinflammation, mostly via regulating the key metabolites. A potential relationship between gut microbiota, metabolites, and neuroinflammation is suggested as a protective mechanism of KXS in AD. These findings provide support for further development of KXS. |
| format | Article |
| id | doaj-art-962d1a61d28b42478f4c18423bf2d208 |
| institution | DOAJ |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-962d1a61d28b42478f4c18423bf2d2082025-08-20T03:21:51ZengElsevieriScience2589-00422025-07-0128711281710.1016/j.isci.2025.112817Metabolomic and microbial insights: Kai-Xin-San’s impact on Alzheimer’s disease pathologyHuifen Ma0Zhiyang Yu1Qiong Qiao2Wenpan Wang3Zhonghua Li4Pan Wang5Junying Song6Xiaowei Zhang7Yunfang Su8Yiran Sun9Zhishen Xie10Zhenqiang Zhang11Collaborative Innovation Center of Prevention and Treatment of Major Diseases by Chinese and Western Medicine, Henan University of Chinese Medicine, Zhengzhou, Henan 450046, China; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan 450046, ChinaAcademy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan 450046, ChinaAcademy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan 450046, ChinaAcademy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan 450046, ChinaCollaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Zhengzhou, Henan 450046, China; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan 450046, ChinaCollaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Zhengzhou, Henan 450046, China; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan 450046, ChinaCollaborative Innovation Center of Prevention and Treatment of Major Diseases by Chinese and Western Medicine, Henan University of Chinese Medicine, Zhengzhou, Henan 450046, China; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan 450046, ChinaCollaborative Innovation Center of Prevention and Treatment of Major Diseases by Chinese and Western Medicine, Henan University of Chinese Medicine, Zhengzhou, Henan 450046, China; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan 450046, ChinaCollaborative Innovation Center of Prevention and Treatment of Major Diseases by Chinese and Western Medicine, Henan University of Chinese Medicine, Zhengzhou, Henan 450046, China; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan 450046, ChinaSchool of Pharmacy, Chengdu Medical College, Chengdu 610500, China; Corresponding authorCollaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Zhengzhou, Henan 450046, China; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan 450046, China; Corresponding authorCollaborative Innovation Center of Prevention and Treatment of Major Diseases by Chinese and Western Medicine, Henan University of Chinese Medicine, Zhengzhou, Henan 450046, China; Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Zhengzhou, Henan 450046, China; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan 450046, China; Corresponding authorSummary: There has been increasing interest in the connection between AD, gut microbiota, and metabolites. Kai-Xin-San (KXS) has been commonly employed in ancient and modern Chinese clinical trials for the treatment of dementia; however, whether the protective effect of KXS in AD is related to the gut microbiota remains elusive. APP/PS1 mice were used as the model of AD. 43 key metabolites influenced by KXS were screened using untargeted metabolomics. At the genus level, Clostridium_IV, Eubacterium, Acetatifactor, etc., were identified to be impacted by KXS using 16S rRNA sequencing. Additionally, we identified 9 distinct intestinal floras at the genus level that were correlated with 13 pivotal differential metabolites related to cognitive impairment. KXS also inhibited the neuroinflammation, mostly via regulating the key metabolites. A potential relationship between gut microbiota, metabolites, and neuroinflammation is suggested as a protective mechanism of KXS in AD. These findings provide support for further development of KXS.http://www.sciencedirect.com/science/article/pii/S2589004225010788Molecular neuroscienceMetabolomics |
| spellingShingle | Huifen Ma Zhiyang Yu Qiong Qiao Wenpan Wang Zhonghua Li Pan Wang Junying Song Xiaowei Zhang Yunfang Su Yiran Sun Zhishen Xie Zhenqiang Zhang Metabolomic and microbial insights: Kai-Xin-San’s impact on Alzheimer’s disease pathology iScience Molecular neuroscience Metabolomics |
| title | Metabolomic and microbial insights: Kai-Xin-San’s impact on Alzheimer’s disease pathology |
| title_full | Metabolomic and microbial insights: Kai-Xin-San’s impact on Alzheimer’s disease pathology |
| title_fullStr | Metabolomic and microbial insights: Kai-Xin-San’s impact on Alzheimer’s disease pathology |
| title_full_unstemmed | Metabolomic and microbial insights: Kai-Xin-San’s impact on Alzheimer’s disease pathology |
| title_short | Metabolomic and microbial insights: Kai-Xin-San’s impact on Alzheimer’s disease pathology |
| title_sort | metabolomic and microbial insights kai xin san s impact on alzheimer s disease pathology |
| topic | Molecular neuroscience Metabolomics |
| url | http://www.sciencedirect.com/science/article/pii/S2589004225010788 |
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