Global, regional, and national burden of myocarditis and its attributable risk factors in 204 countries and territories from 1990 to 2021: updated systematic analysis
BackgroundComprehending the current epidemiological trends and risk factors of myocarditis is crucial for guiding future targeted prevention and treatment strategies.MethodsUtilizing data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021, we conducted a secondary analysis of...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-04-01
|
| Series: | Frontiers in Public Health |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1542921/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850172551007830016 |
|---|---|
| author | Jiajia Ren Wanyuan Liu Xuting Jin Chuchu Zhang Xi Xu Guorong Deng Xiaoming Gao Jiamei Li Ruohan Li Xiaoling Zhang Yanli Hou Gang Wang Gang Wang |
| author_facet | Jiajia Ren Wanyuan Liu Xuting Jin Chuchu Zhang Xi Xu Guorong Deng Xiaoming Gao Jiamei Li Ruohan Li Xiaoling Zhang Yanli Hou Gang Wang Gang Wang |
| author_sort | Jiajia Ren |
| collection | DOAJ |
| description | BackgroundComprehending the current epidemiological trends and risk factors of myocarditis is crucial for guiding future targeted prevention and treatment strategies.MethodsUtilizing data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021, we conducted a secondary analysis of the incidence, prevalence, death, and disability-adjusted life years (DALYs) of myocarditis by sex, age group and socio-demographic index (SDI) across 204 countries and territories from 1990 to 2021. And non-optimal temperatures, defined as same-day exposure to ambient temperatures deviating from the minimum death risk threshold, were identified as risk-factors for myocarditis-related death and DALYs.ResultsFrom 1990 to 2021, the global prevalence of myocarditis increased from 320,623 (95% uncertainty interval: 268,557 to 371,912) to 505,030 (432,295 to 587,819). Concurrently, the age-standardized prevalence rate (ASPR) per 100,000 people also saw a slight increase (no statistical significance) from 6.35 (5.37 to 7.36) to 6.41 (5.48 to 7.44). However, the age-standardized incidence rate (ASIR), age-standardized death rate (ASDR) and age-standardized DALY rate (ASYR) exhibited declines, with estimated annual percentage changes of −0.20 (−0.23 to −0.17), −1.37 (−1.81 to −0.92) and −1.71 (−1.95 to −1.46), respectively. SDI quintile analysis showed that the high SDI quintile had the highest ASIR and ASPR, while the middle and high-middle SDI quintiles exhibited the highest ASDR and ASYR. Furthermore, the burden of myocarditis was notably high among males and older adult populations. Non-optimal temperature, particularly low temperature, emerged as a key risk factor for myocarditis-related ASDR and ASYR.ConclusionAlthough the ASIR, ASDR and ASYR for myocarditis exhibited decreasing trends from 1990 to 2019, further efforts are needed to develop targeted public health strategies, especially for low SDI regions, males, and older adult populations. |
| format | Article |
| id | doaj-art-962b5c337b68491f9bd4809d654c2805 |
| institution | OA Journals |
| issn | 2296-2565 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj-art-962b5c337b68491f9bd4809d654c28052025-08-20T02:20:03ZengFrontiers Media S.A.Frontiers in Public Health2296-25652025-04-011310.3389/fpubh.2025.15429211542921Global, regional, and national burden of myocarditis and its attributable risk factors in 204 countries and territories from 1990 to 2021: updated systematic analysisJiajia Ren0Wanyuan Liu1Xuting Jin2Chuchu Zhang3Xi Xu4Guorong Deng5Xiaoming Gao6Jiamei Li7Ruohan Li8Xiaoling Zhang9Yanli Hou10Gang Wang11Gang Wang12Department of Critical Care Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Critical Care Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Critical Care Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Critical Care Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Critical Care Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Critical Care Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Critical Care Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Critical Care Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Critical Care Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Critical Care Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Critical Care Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Critical Care Medicine, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaKey Laboratory of Surgical Critical Care and Life Support, Xi'an Jiaotong University, Ministry of Education, Xi'an, ChinaBackgroundComprehending the current epidemiological trends and risk factors of myocarditis is crucial for guiding future targeted prevention and treatment strategies.MethodsUtilizing data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021, we conducted a secondary analysis of the incidence, prevalence, death, and disability-adjusted life years (DALYs) of myocarditis by sex, age group and socio-demographic index (SDI) across 204 countries and territories from 1990 to 2021. And non-optimal temperatures, defined as same-day exposure to ambient temperatures deviating from the minimum death risk threshold, were identified as risk-factors for myocarditis-related death and DALYs.ResultsFrom 1990 to 2021, the global prevalence of myocarditis increased from 320,623 (95% uncertainty interval: 268,557 to 371,912) to 505,030 (432,295 to 587,819). Concurrently, the age-standardized prevalence rate (ASPR) per 100,000 people also saw a slight increase (no statistical significance) from 6.35 (5.37 to 7.36) to 6.41 (5.48 to 7.44). However, the age-standardized incidence rate (ASIR), age-standardized death rate (ASDR) and age-standardized DALY rate (ASYR) exhibited declines, with estimated annual percentage changes of −0.20 (−0.23 to −0.17), −1.37 (−1.81 to −0.92) and −1.71 (−1.95 to −1.46), respectively. SDI quintile analysis showed that the high SDI quintile had the highest ASIR and ASPR, while the middle and high-middle SDI quintiles exhibited the highest ASDR and ASYR. Furthermore, the burden of myocarditis was notably high among males and older adult populations. Non-optimal temperature, particularly low temperature, emerged as a key risk factor for myocarditis-related ASDR and ASYR.ConclusionAlthough the ASIR, ASDR and ASYR for myocarditis exhibited decreasing trends from 1990 to 2019, further efforts are needed to develop targeted public health strategies, especially for low SDI regions, males, and older adult populations.https://www.frontiersin.org/articles/10.3389/fpubh.2025.1542921/fullmyocarditisGlobal Burden of Diseaseincidenceprevalencedeathdisability-adjusted life years |
| spellingShingle | Jiajia Ren Wanyuan Liu Xuting Jin Chuchu Zhang Xi Xu Guorong Deng Xiaoming Gao Jiamei Li Ruohan Li Xiaoling Zhang Yanli Hou Gang Wang Gang Wang Global, regional, and national burden of myocarditis and its attributable risk factors in 204 countries and territories from 1990 to 2021: updated systematic analysis Frontiers in Public Health myocarditis Global Burden of Disease incidence prevalence death disability-adjusted life years |
| title | Global, regional, and national burden of myocarditis and its attributable risk factors in 204 countries and territories from 1990 to 2021: updated systematic analysis |
| title_full | Global, regional, and national burden of myocarditis and its attributable risk factors in 204 countries and territories from 1990 to 2021: updated systematic analysis |
| title_fullStr | Global, regional, and national burden of myocarditis and its attributable risk factors in 204 countries and territories from 1990 to 2021: updated systematic analysis |
| title_full_unstemmed | Global, regional, and national burden of myocarditis and its attributable risk factors in 204 countries and territories from 1990 to 2021: updated systematic analysis |
| title_short | Global, regional, and national burden of myocarditis and its attributable risk factors in 204 countries and territories from 1990 to 2021: updated systematic analysis |
| title_sort | global regional and national burden of myocarditis and its attributable risk factors in 204 countries and territories from 1990 to 2021 updated systematic analysis |
| topic | myocarditis Global Burden of Disease incidence prevalence death disability-adjusted life years |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1542921/full |
| work_keys_str_mv | AT jiajiaren globalregionalandnationalburdenofmyocarditisanditsattributableriskfactorsin204countriesandterritoriesfrom1990to2021updatedsystematicanalysis AT wanyuanliu globalregionalandnationalburdenofmyocarditisanditsattributableriskfactorsin204countriesandterritoriesfrom1990to2021updatedsystematicanalysis AT xutingjin globalregionalandnationalburdenofmyocarditisanditsattributableriskfactorsin204countriesandterritoriesfrom1990to2021updatedsystematicanalysis AT chuchuzhang globalregionalandnationalburdenofmyocarditisanditsattributableriskfactorsin204countriesandterritoriesfrom1990to2021updatedsystematicanalysis AT xixu globalregionalandnationalburdenofmyocarditisanditsattributableriskfactorsin204countriesandterritoriesfrom1990to2021updatedsystematicanalysis AT guorongdeng globalregionalandnationalburdenofmyocarditisanditsattributableriskfactorsin204countriesandterritoriesfrom1990to2021updatedsystematicanalysis AT xiaominggao globalregionalandnationalburdenofmyocarditisanditsattributableriskfactorsin204countriesandterritoriesfrom1990to2021updatedsystematicanalysis AT jiameili globalregionalandnationalburdenofmyocarditisanditsattributableriskfactorsin204countriesandterritoriesfrom1990to2021updatedsystematicanalysis AT ruohanli globalregionalandnationalburdenofmyocarditisanditsattributableriskfactorsin204countriesandterritoriesfrom1990to2021updatedsystematicanalysis AT xiaolingzhang globalregionalandnationalburdenofmyocarditisanditsattributableriskfactorsin204countriesandterritoriesfrom1990to2021updatedsystematicanalysis AT yanlihou globalregionalandnationalburdenofmyocarditisanditsattributableriskfactorsin204countriesandterritoriesfrom1990to2021updatedsystematicanalysis AT gangwang globalregionalandnationalburdenofmyocarditisanditsattributableriskfactorsin204countriesandterritoriesfrom1990to2021updatedsystematicanalysis AT gangwang globalregionalandnationalburdenofmyocarditisanditsattributableriskfactorsin204countriesandterritoriesfrom1990to2021updatedsystematicanalysis |