Consensus document APAIR: atopic dermatitis in children — update 2019 (short version) Part 1.
Atopic eczema (atopic dermatitis, AD) — chronic recurrent inflammation of the skin, arising as a result of a violation of the epidermal barrier and entailing its further dysfunction. Maximum development atopic dermatitis reaches on the background of predisposition to IgE-mediated hypersensitivi...
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| Format: | Article |
| Language: | Russian |
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Association of Paediatric Allergists and Immunologists of Russia (APAIR)
2023-03-01
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| Series: | Аллергология и Иммунология в Педиатрии |
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| Online Access: | https://adair.elpub.ru/jour/article/view/15 |
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| author | Yu. S. Smolkin I. I. Balabolkin I. A. Gorlanov L. S. Kruglova A. V. Kudryavtseva R. Y. Meshkova H. B. Migacheva R. F. Khakimova A. A. Cheburkin E. A. Kuropatnikova N. A. Lyan A. V. Maksimova S. S. Masalskiy O. Y. Smolkina |
| author_facet | Yu. S. Smolkin I. I. Balabolkin I. A. Gorlanov L. S. Kruglova A. V. Kudryavtseva R. Y. Meshkova H. B. Migacheva R. F. Khakimova A. A. Cheburkin E. A. Kuropatnikova N. A. Lyan A. V. Maksimova S. S. Masalskiy O. Y. Smolkina |
| author_sort | Yu. S. Smolkin |
| collection | DOAJ |
| description | Atopic eczema (atopic dermatitis, AD) — chronic recurrent inflammation of the skin, arising as a result of a violation of the epidermal barrier and entailing its further dysfunction. Maximum development atopic dermatitis reaches on the background of predisposition to IgE-mediated hypersensitivity, implemented in sensitization to surrounding allergens.The diagnosis of atopic eczema is clinical. An obligatory clinical symptom is itching in combination with 3 other criteria: typical morphology and distribution; a history of atopy; chronically xerosis; AD debut up to 2 years. The phase of the disease and the severity of skin lesions are of practical importance for clarifying the stage AD. Changes characteristic of different phases can be observed simultaneously. Morphological and age-related classifications of AD are conditional and have little effect on the therapeutic strategy. Clinical variants of AD (allergic and non-allergic) are a single nosological form that requires common approaches to therapy. The prevalence of AD is greatest in children a 1-st year of life (up to 30%) and significantly decreases in adolescence.Point and inherited mutations in genes (for example, filaggrin) are a key point in the pathogenesis of AD. Immune disorders are not limited to IgE-dependent reactions and occur with the participation of many cytokines (IL-4, IL-5, IL-13, IL-25, IL-31, TSLP). Bacteria and fungi act as infectious agents or superantigens for lymphocytes.Food allergies are detected in 30–40% of children with AD causing aggravation of the disease. The children in the first year dominated by sensitization to food allergens: milk, eggs, cereals, fish. An allergological examination using skin prick tests or specific IgE is informative and necessary, but the presence of sensitization should be clarified using an elimination-provocation test with this product. |
| format | Article |
| id | doaj-art-9629a724a9be43369acbf2f098ef21a7 |
| institution | DOAJ |
| issn | 2500-1175 2712-7958 |
| language | Russian |
| publishDate | 2023-03-01 |
| publisher | Association of Paediatric Allergists and Immunologists of Russia (APAIR) |
| record_format | Article |
| series | Аллергология и Иммунология в Педиатрии |
| spelling | doaj-art-9629a724a9be43369acbf2f098ef21a72025-08-20T02:49:53ZrusAssociation of Paediatric Allergists and Immunologists of Russia (APAIR)Аллергология и Иммунология в Педиатрии2500-11752712-79582023-03-010142510.24411/2500-1175-2020-1000114Consensus document APAIR: atopic dermatitis in children — update 2019 (short version) Part 1.Yu. S. Smolkin0I. I. Balabolkin1I. A. Gorlanov2L. S. Kruglova3A. V. Kudryavtseva4R. Y. Meshkova5H. B. Migacheva6R. F. Khakimova7A. A. Cheburkin8E. A. Kuropatnikova9N. A. Lyan10A. V. Maksimova11S. S. Masalskiy12O. Y. Smolkina13Association Pediatric Allergist and Immunologist Russia; Federal State Budget Founding Federal Research and Clinical Center of specialized types of health care and medical technology of the Federal Medical and Biological Agency; «Scientific-Clinical Consultative Center of Allergology and Immunology», L.t.d.Association Pediatric Allergist and Immunologist Russia; National Medical Research Center for Children’s Health Federal state autonomous institution of the Russian Federation Ministry of HealthSt. Petersburg State Pediatric Medical UniversityCentral State Medical Academy of Department of President AffairsAssociation Pediatric Allergist and Immunologist Russia; Sechenov First Moscow State Medical UniversityAssociation Pediatric Allergist and Immunologist Russia; Smolensk State Medical University of Ministry of Healthcare of the Russian FederationAssociation Pediatric Allergist and Immunologist Russia; V.I. Razumovsky Saratov State Medical University» of Ministry of Healthcare of the Russian FederationAssociation Pediatric Allergist and Immunologist Russia; Kazan State Medical University of Ministry of Healthcare of the Russian FederationAssociation Pediatric Allergist and Immunologist Russia; Russian Medical Academy of Postgraduate EducationAssociation Pediatric Allergist and Immunologist Russia; Scientific-Clinical Consultative Center of Allergology and Immunology», L.t.d.Association Pediatric Allergist and Immunologist Russia; Sechenov First Moscow State Medical UniversityAssociation Pediatric Allergist and Immunologist Russia; Scientific-Clinical Consultative Center of Allergology and Immunology», L.t.d.Association Pediatric Allergist and Immunologist Russia; Scientific-Clinical Consultative Center of Allergology and Immunology», L.t.d.Association Pediatric Allergist and Immunologist Russia; Scientific-Clinical Consultative Center of Allergology and Immunology», L.t.d.Atopic eczema (atopic dermatitis, AD) — chronic recurrent inflammation of the skin, arising as a result of a violation of the epidermal barrier and entailing its further dysfunction. Maximum development atopic dermatitis reaches on the background of predisposition to IgE-mediated hypersensitivity, implemented in sensitization to surrounding allergens.The diagnosis of atopic eczema is clinical. An obligatory clinical symptom is itching in combination with 3 other criteria: typical morphology and distribution; a history of atopy; chronically xerosis; AD debut up to 2 years. The phase of the disease and the severity of skin lesions are of practical importance for clarifying the stage AD. Changes characteristic of different phases can be observed simultaneously. Morphological and age-related classifications of AD are conditional and have little effect on the therapeutic strategy. Clinical variants of AD (allergic and non-allergic) are a single nosological form that requires common approaches to therapy. The prevalence of AD is greatest in children a 1-st year of life (up to 30%) and significantly decreases in adolescence.Point and inherited mutations in genes (for example, filaggrin) are a key point in the pathogenesis of AD. Immune disorders are not limited to IgE-dependent reactions and occur with the participation of many cytokines (IL-4, IL-5, IL-13, IL-25, IL-31, TSLP). Bacteria and fungi act as infectious agents or superantigens for lymphocytes.Food allergies are detected in 30–40% of children with AD causing aggravation of the disease. The children in the first year dominated by sensitization to food allergens: milk, eggs, cereals, fish. An allergological examination using skin prick tests or specific IgE is informative and necessary, but the presence of sensitization should be clarified using an elimination-provocation test with this product.https://adair.elpub.ru/jour/article/view/15atopic eczemaatopic dermatitischildrenguidelineapair |
| spellingShingle | Yu. S. Smolkin I. I. Balabolkin I. A. Gorlanov L. S. Kruglova A. V. Kudryavtseva R. Y. Meshkova H. B. Migacheva R. F. Khakimova A. A. Cheburkin E. A. Kuropatnikova N. A. Lyan A. V. Maksimova S. S. Masalskiy O. Y. Smolkina Consensus document APAIR: atopic dermatitis in children — update 2019 (short version) Part 1. Аллергология и Иммунология в Педиатрии atopic eczema atopic dermatitis children guideline apair |
| title | Consensus document APAIR: atopic dermatitis in children — update 2019 (short version) Part 1. |
| title_full | Consensus document APAIR: atopic dermatitis in children — update 2019 (short version) Part 1. |
| title_fullStr | Consensus document APAIR: atopic dermatitis in children — update 2019 (short version) Part 1. |
| title_full_unstemmed | Consensus document APAIR: atopic dermatitis in children — update 2019 (short version) Part 1. |
| title_short | Consensus document APAIR: atopic dermatitis in children — update 2019 (short version) Part 1. |
| title_sort | consensus document apair atopic dermatitis in children update 2019 short version part 1 |
| topic | atopic eczema atopic dermatitis children guideline apair |
| url | https://adair.elpub.ru/jour/article/view/15 |
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