Single cell transcriptomic analysis reveals tumor immune infiltration by macrophage cells gene signature in lung adenocarcinoma

Single cell transcriptomic analysis reveals tumor immune infiltration by macrophage cells gene signature in lung adenocarcinoma

Abstract Background Tumor-associated macrophages (TAMs) play pivotal roles in innate immunity and contribute to the advancement of lung cancer. We aimed to identify novel TAM-related biomarkers and significance of macrophage infiltration in lung adenocarcinoma (LUAD) through an integrative analysis...

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Bibliographic Details
Main Authors: Xiaotong Guo, Youjun Deng, Wenjun Jiang, Heng Li, Yisheng Luo, Huachuan Zhang, Hao Wu
Format: Article
Language:English
Published: Springer 2025-03-01
Series:Discover Oncology
Subjects:
Single-cell RNA-sequencing
Tumor-associated macrophages (TAMs)
Lung adenocarcinoma (LUAD)
Prognosis
TGF-β signaling
Immune infiltration
Online Access:https://doi.org/10.1007/s12672-025-01834-7
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