Ultrafast fMRI reveals serial queuing of information processing during multitasking in the human brain

Abstract The human brain is heralded for its massive parallel processing capacity, yet influential cognitive models suggest that there is a central bottleneck of information processing distinct from perceptual and motor stages that limits our ability to carry out two cognitively demanding tasks at o...

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Main Authors: Qiuhai Yue, Allen T. Newton, René Marois
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58228-0
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author Qiuhai Yue
Allen T. Newton
René Marois
author_facet Qiuhai Yue
Allen T. Newton
René Marois
author_sort Qiuhai Yue
collection DOAJ
description Abstract The human brain is heralded for its massive parallel processing capacity, yet influential cognitive models suggest that there is a central bottleneck of information processing distinct from perceptual and motor stages that limits our ability to carry out two cognitively demanding tasks at once, resulting in the serial queuing of task information processing. Here we used ultrafast (199 ms TR), high-field (7T) fMRI with multivariate analyses to distinguish brain activity between two arbitrary sensorimotor response selection tasks when the tasks were temporally overlapping. We observed serial processing of task-specific activity in the fronto-parietal multiple-demand (MD) network, while processing in earlier sensory stages unfolded largely in parallel. Moreover, the MD network combined with modality-specific motor areas to define the functional characteristic of the central bottleneck at the stage of response selection. These results provide direct neural evidence for serial queuing of information processing and pinpoint the neural substrates undergirding the central bottleneck.
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issn 2041-1723
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spelling doaj-art-961794bce59f43bbbabcc09f8c29c1cc2025-08-20T03:40:48ZengNature PortfolioNature Communications2041-17232025-03-0116112110.1038/s41467-025-58228-0Ultrafast fMRI reveals serial queuing of information processing during multitasking in the human brainQiuhai Yue0Allen T. Newton1René Marois2School of Psychology, Shenzhen UniversityVanderbilt University Medical CenterDepartment of Psychology, Vanderbilt UniversityAbstract The human brain is heralded for its massive parallel processing capacity, yet influential cognitive models suggest that there is a central bottleneck of information processing distinct from perceptual and motor stages that limits our ability to carry out two cognitively demanding tasks at once, resulting in the serial queuing of task information processing. Here we used ultrafast (199 ms TR), high-field (7T) fMRI with multivariate analyses to distinguish brain activity between two arbitrary sensorimotor response selection tasks when the tasks were temporally overlapping. We observed serial processing of task-specific activity in the fronto-parietal multiple-demand (MD) network, while processing in earlier sensory stages unfolded largely in parallel. Moreover, the MD network combined with modality-specific motor areas to define the functional characteristic of the central bottleneck at the stage of response selection. These results provide direct neural evidence for serial queuing of information processing and pinpoint the neural substrates undergirding the central bottleneck.https://doi.org/10.1038/s41467-025-58228-0
spellingShingle Qiuhai Yue
Allen T. Newton
René Marois
Ultrafast fMRI reveals serial queuing of information processing during multitasking in the human brain
Nature Communications
title Ultrafast fMRI reveals serial queuing of information processing during multitasking in the human brain
title_full Ultrafast fMRI reveals serial queuing of information processing during multitasking in the human brain
title_fullStr Ultrafast fMRI reveals serial queuing of information processing during multitasking in the human brain
title_full_unstemmed Ultrafast fMRI reveals serial queuing of information processing during multitasking in the human brain
title_short Ultrafast fMRI reveals serial queuing of information processing during multitasking in the human brain
title_sort ultrafast fmri reveals serial queuing of information processing during multitasking in the human brain
url https://doi.org/10.1038/s41467-025-58228-0
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AT allentnewton ultrafastfmrirevealsserialqueuingofinformationprocessingduringmultitaskinginthehumanbrain
AT renemarois ultrafastfmrirevealsserialqueuingofinformationprocessingduringmultitaskinginthehumanbrain