Severe forms of neurocysticercosis: treatment with albendazole Formas graves da neurocisticercose: tratamento com albendazol
Study of 22 patients with the severe form of neurocysticercosis treated with albendazole (ABZ) administered in 6 different schedules ranging from 15 to 30 mg/kg/day for 21 to 60 days. Dextrochloropheniramine and ketoprofen were the adjuvant drugs. Multiple symptoms were observed in 90.9% of patients...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Thieme Revinter Publicações
1996-03-01
|
| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1996000100014 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849693027912646656 |
|---|---|
| author | Svetlana Agapejev Maria Dorvalina da Silva Anete K. Ueda |
| author_facet | Svetlana Agapejev Maria Dorvalina da Silva Anete K. Ueda |
| author_sort | Svetlana Agapejev |
| collection | DOAJ |
| description | Study of 22 patients with the severe form of neurocysticercosis treated with albendazole (ABZ) administered in 6 different schedules ranging from 15 to 30 mg/kg/day for 21 to 60 days. Dextrochloropheniramine and ketoprofen were the adjuvant drugs. Multiple symptoms were observed in 90.9% of patients. Intracranial hypertension was manifested in 90.9%. Hydrocephaly occurred in 86.4%. Evolution was satisfactory in 10 patients, 8 died and 4 had sequelae. Tomographic studies showed the appearance of an isolated IVth ventricle in 9 patients, after ventriculoperitoneal shunt, before ABZ treatment in 3 of them, during in 5 and after treatment in one. Median clinical follow-up duration was 10 months for the patients who died and 3-4 years for survivors. In 3 patients there was an increase in cyst size during the administration of the 15 mg/kg/day ABZ dose, which was not observed in any patient when the 30 mg/kg/day dose was used.<br>Estudo de 22 doentes, com a forma grave de neurocisticercose, tratados com albendazol (ABZ), administrado em 6 diferentes esquemas, que variaram de 15 a 30 mg/kg/dia, durante 21 a 60 dias. A dextroclorofeniramina e o cetoprofeno foram as drogas coadjuvantes. Múltiplos sintomas ocorreram em 20 doentes. Hipertensão intracraniana foi manifestação mais comum em 20. Hidrocefalia foi detectada em 19. A evolução foi satisfatória em 45,4%, faleceram 36,4% e 18,2% ficaram com sequelas. Na evolução tomográfica apareceu IVº ventrículo isolado em 40,9%, após derivação ventriculoperitoneal, em 3 deles antes do tratamento com ABZ, em 5 durante e, em um, após o tratamento. A mediana estatística do período de seguimento clínico foi 10 meses para aqueles que faleceram e 3-4 anos para os sobreviventes. Em 3 doentes houve aumento no tamanho dos cistos durante a dose de 15 mg/kg/dia de ABZ, não observado na vigência de 30 mg/kg/dia. |
| format | Article |
| id | doaj-art-96165a9408044e5da98e7056a65b0aa0 |
| institution | DOAJ |
| issn | 0004-282X 1678-4227 |
| language | English |
| publishDate | 1996-03-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-96165a9408044e5da98e7056a65b0aa02025-08-20T03:20:33ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria0004-282X1678-42271996-03-01541829310.1590/S0004-282X1996000100014Severe forms of neurocysticercosis: treatment with albendazole Formas graves da neurocisticercose: tratamento com albendazolSvetlana AgapejevMaria Dorvalina da SilvaAnete K. UedaStudy of 22 patients with the severe form of neurocysticercosis treated with albendazole (ABZ) administered in 6 different schedules ranging from 15 to 30 mg/kg/day for 21 to 60 days. Dextrochloropheniramine and ketoprofen were the adjuvant drugs. Multiple symptoms were observed in 90.9% of patients. Intracranial hypertension was manifested in 90.9%. Hydrocephaly occurred in 86.4%. Evolution was satisfactory in 10 patients, 8 died and 4 had sequelae. Tomographic studies showed the appearance of an isolated IVth ventricle in 9 patients, after ventriculoperitoneal shunt, before ABZ treatment in 3 of them, during in 5 and after treatment in one. Median clinical follow-up duration was 10 months for the patients who died and 3-4 years for survivors. In 3 patients there was an increase in cyst size during the administration of the 15 mg/kg/day ABZ dose, which was not observed in any patient when the 30 mg/kg/day dose was used.<br>Estudo de 22 doentes, com a forma grave de neurocisticercose, tratados com albendazol (ABZ), administrado em 6 diferentes esquemas, que variaram de 15 a 30 mg/kg/dia, durante 21 a 60 dias. A dextroclorofeniramina e o cetoprofeno foram as drogas coadjuvantes. Múltiplos sintomas ocorreram em 20 doentes. Hipertensão intracraniana foi manifestação mais comum em 20. Hidrocefalia foi detectada em 19. A evolução foi satisfatória em 45,4%, faleceram 36,4% e 18,2% ficaram com sequelas. Na evolução tomográfica apareceu IVº ventrículo isolado em 40,9%, após derivação ventriculoperitoneal, em 3 deles antes do tratamento com ABZ, em 5 durante e, em um, após o tratamento. A mediana estatística do período de seguimento clínico foi 10 meses para aqueles que faleceram e 3-4 anos para os sobreviventes. Em 3 doentes houve aumento no tamanho dos cistos durante a dose de 15 mg/kg/dia de ABZ, não observado na vigência de 30 mg/kg/dia.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1996000100014cisticercoseneurocisticercoseformas gravestratamentoalbendazoldextroclorofeniraminacetoprofenocysticercosisneurocysticercosissevere formstreatmentalbendazoledextrochloropheniramineketoprofen |
| spellingShingle | Svetlana Agapejev Maria Dorvalina da Silva Anete K. Ueda Severe forms of neurocysticercosis: treatment with albendazole Formas graves da neurocisticercose: tratamento com albendazol Arquivos de Neuro-Psiquiatria cisticercose neurocisticercose formas graves tratamento albendazol dextroclorofeniramina cetoprofeno cysticercosis neurocysticercosis severe forms treatment albendazole dextrochloropheniramine ketoprofen |
| title | Severe forms of neurocysticercosis: treatment with albendazole Formas graves da neurocisticercose: tratamento com albendazol |
| title_full | Severe forms of neurocysticercosis: treatment with albendazole Formas graves da neurocisticercose: tratamento com albendazol |
| title_fullStr | Severe forms of neurocysticercosis: treatment with albendazole Formas graves da neurocisticercose: tratamento com albendazol |
| title_full_unstemmed | Severe forms of neurocysticercosis: treatment with albendazole Formas graves da neurocisticercose: tratamento com albendazol |
| title_short | Severe forms of neurocysticercosis: treatment with albendazole Formas graves da neurocisticercose: tratamento com albendazol |
| title_sort | severe forms of neurocysticercosis treatment with albendazole formas graves da neurocisticercose tratamento com albendazol |
| topic | cisticercose neurocisticercose formas graves tratamento albendazol dextroclorofeniramina cetoprofeno cysticercosis neurocysticercosis severe forms treatment albendazole dextrochloropheniramine ketoprofen |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1996000100014 |
| work_keys_str_mv | AT svetlanaagapejev severeformsofneurocysticercosistreatmentwithalbendazoleformasgravesdaneurocisticercosetratamentocomalbendazol AT mariadorvalinadasilva severeformsofneurocysticercosistreatmentwithalbendazoleformasgravesdaneurocisticercosetratamentocomalbendazol AT anetekueda severeformsofneurocysticercosistreatmentwithalbendazoleformasgravesdaneurocisticercosetratamentocomalbendazol |