Milk-derived bioactive peptides
Abstract Bioactive peptides are the functional concept that refer to fragments of proteins that provide both functional and nutritional benefits as a functional component. Milk has been widely exploited as a source of diverse bioactive peptides. Bioactivity of peptides depends on amino acid composit...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Food Production, Processing and Nutrition |
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| Online Access: | https://doi.org/10.1186/s43014-024-00280-2 |
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| _version_ | 1850119347022856192 |
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| author | Phareichon Kashung Devi Karuthapandian |
| author_facet | Phareichon Kashung Devi Karuthapandian |
| author_sort | Phareichon Kashung |
| collection | DOAJ |
| description | Abstract Bioactive peptides are the functional concept that refer to fragments of proteins that provide both functional and nutritional benefits as a functional component. Milk has been widely exploited as a source of diverse bioactive peptides. Bioactivity of peptides depends on amino acid composition and sequence specific to bioactivity. The production of bioactive peptides can be carried out through classical and bioinformatics approaches. In the classical approach, enzymatic hydrolysis, simulated digestion and hydrolysis by microbial enzymes are included. In the bioinformatics approach, databases, QSAR modeling, molecular docking and design of experiments (DoE) with response surface methodology are employed for identification and characterization of bioactive peptides from milk proteins. Milk-derived peptides have been identified to be antihypertensive, anti-diabetic, cytomodulatory, antioxidative, antimicrobial, and mineral binding peptides with wide applications as nutraceuticals in commercial products and food preservatives in food industry. Hence, this review has attempted to provide insight into the approaches and applications of milk- derived bioactive peptides with nutraceuticals properties in the development of functional foods. Graphical Abstract |
| format | Article |
| id | doaj-art-95fceb2afc3146838c05c6f2e36ae35e |
| institution | OA Journals |
| issn | 2661-8974 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Food Production, Processing and Nutrition |
| spelling | doaj-art-95fceb2afc3146838c05c6f2e36ae35e2025-08-20T02:35:39ZengBMCFood Production, Processing and Nutrition2661-89742025-01-017111910.1186/s43014-024-00280-2Milk-derived bioactive peptidesPhareichon Kashung0Devi Karuthapandian1Department of Food Science and Nutrition, Avinashilingam Institute for Home Science and Higher Education for Women, Tamil NaduDepartment of Food Science and Nutrition, Avinashilingam Institute for Home Science and Higher Education for Women, Tamil NaduAbstract Bioactive peptides are the functional concept that refer to fragments of proteins that provide both functional and nutritional benefits as a functional component. Milk has been widely exploited as a source of diverse bioactive peptides. Bioactivity of peptides depends on amino acid composition and sequence specific to bioactivity. The production of bioactive peptides can be carried out through classical and bioinformatics approaches. In the classical approach, enzymatic hydrolysis, simulated digestion and hydrolysis by microbial enzymes are included. In the bioinformatics approach, databases, QSAR modeling, molecular docking and design of experiments (DoE) with response surface methodology are employed for identification and characterization of bioactive peptides from milk proteins. Milk-derived peptides have been identified to be antihypertensive, anti-diabetic, cytomodulatory, antioxidative, antimicrobial, and mineral binding peptides with wide applications as nutraceuticals in commercial products and food preservatives in food industry. Hence, this review has attempted to provide insight into the approaches and applications of milk- derived bioactive peptides with nutraceuticals properties in the development of functional foods. Graphical Abstracthttps://doi.org/10.1186/s43014-024-00280-2Bioactive PeptidesMilk ProteinEnzymatic HydrolysisSimulated DigestionMicrobial fermentationBioinformatics Approach |
| spellingShingle | Phareichon Kashung Devi Karuthapandian Milk-derived bioactive peptides Food Production, Processing and Nutrition Bioactive Peptides Milk Protein Enzymatic Hydrolysis Simulated Digestion Microbial fermentation Bioinformatics Approach |
| title | Milk-derived bioactive peptides |
| title_full | Milk-derived bioactive peptides |
| title_fullStr | Milk-derived bioactive peptides |
| title_full_unstemmed | Milk-derived bioactive peptides |
| title_short | Milk-derived bioactive peptides |
| title_sort | milk derived bioactive peptides |
| topic | Bioactive Peptides Milk Protein Enzymatic Hydrolysis Simulated Digestion Microbial fermentation Bioinformatics Approach |
| url | https://doi.org/10.1186/s43014-024-00280-2 |
| work_keys_str_mv | AT phareichonkashung milkderivedbioactivepeptides AT devikaruthapandian milkderivedbioactivepeptides |