Role of the endothelial cell glycocalyx in sepsis-induced acute kidney injury
Sepsis-induced acute kidney injury (S-AKI) is a common complication of sepsis. It occurs at high incidence and is associated with a high level of mortality in the intensive care unit (ICU). The pathophysiologic mechanisms underlying S-AKI are complex, and include renal vascular endothelial cell dysf...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1535673/full |
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| author | Yixun Wang Yixun Wang Yixun Wang Zhaohui Zhang Zhaohui Zhang Zhaohui Zhang Xingguang Qu Xingguang Qu Xingguang Qu Gaosheng Zhou Gaosheng Zhou Gaosheng Zhou |
| author_facet | Yixun Wang Yixun Wang Yixun Wang Zhaohui Zhang Zhaohui Zhang Zhaohui Zhang Xingguang Qu Xingguang Qu Xingguang Qu Gaosheng Zhou Gaosheng Zhou Gaosheng Zhou |
| author_sort | Yixun Wang |
| collection | DOAJ |
| description | Sepsis-induced acute kidney injury (S-AKI) is a common complication of sepsis. It occurs at high incidence and is associated with a high level of mortality in the intensive care unit (ICU). The pathophysiologic mechanisms underlying S-AKI are complex, and include renal vascular endothelial cell dysfunction. The endothelial glycocalyx (EG) is a polysaccharide/protein complex located on the cell membrane at the luminal surface of vascular endothelial cells that has anti-inflammatory, anti-thrombotic, and endothelial protective effects. Recent studies have shown that glycocalyx damage plays a causal role in S-AKI progression. In this review, we first describe the structure, location, and basic function of the EG. Second, we analyze the underlying mechanisms of EG degradation in sepsis and S-AKI. Finally, we provide a summary of the potential therapeutic strategies that target the EG. |
| format | Article |
| id | doaj-art-95fbc7ebd7784f148c2d8b8300d35f76 |
| institution | OA Journals |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-95fbc7ebd7784f148c2d8b8300d35f762025-08-20T01:51:53ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-04-011210.3389/fmed.2025.15356731535673Role of the endothelial cell glycocalyx in sepsis-induced acute kidney injuryYixun Wang0Yixun Wang1Yixun Wang2Zhaohui Zhang3Zhaohui Zhang4Zhaohui Zhang5Xingguang Qu6Xingguang Qu7Xingguang Qu8Gaosheng Zhou9Gaosheng Zhou10Gaosheng Zhou11The First College of Clinical Medical Science, China Three Gorges University, Yichang, ChinaDepartment of Critical Care Medicine, Yichang Central People's Hospital, Yichang, ChinaYichang Sepsis Clinical Research Center, Yichang, Hubei, ChinaThe First College of Clinical Medical Science, China Three Gorges University, Yichang, ChinaDepartment of Critical Care Medicine, Yichang Central People's Hospital, Yichang, ChinaYichang Sepsis Clinical Research Center, Yichang, Hubei, ChinaThe First College of Clinical Medical Science, China Three Gorges University, Yichang, ChinaDepartment of Critical Care Medicine, Yichang Central People's Hospital, Yichang, ChinaYichang Sepsis Clinical Research Center, Yichang, Hubei, ChinaThe First College of Clinical Medical Science, China Three Gorges University, Yichang, ChinaDepartment of Critical Care Medicine, Yichang Central People's Hospital, Yichang, ChinaYichang Sepsis Clinical Research Center, Yichang, Hubei, ChinaSepsis-induced acute kidney injury (S-AKI) is a common complication of sepsis. It occurs at high incidence and is associated with a high level of mortality in the intensive care unit (ICU). The pathophysiologic mechanisms underlying S-AKI are complex, and include renal vascular endothelial cell dysfunction. The endothelial glycocalyx (EG) is a polysaccharide/protein complex located on the cell membrane at the luminal surface of vascular endothelial cells that has anti-inflammatory, anti-thrombotic, and endothelial protective effects. Recent studies have shown that glycocalyx damage plays a causal role in S-AKI progression. In this review, we first describe the structure, location, and basic function of the EG. Second, we analyze the underlying mechanisms of EG degradation in sepsis and S-AKI. Finally, we provide a summary of the potential therapeutic strategies that target the EG.https://www.frontiersin.org/articles/10.3389/fmed.2025.1535673/fullglycocalyxsepsisendotheliumkidneyinflammation |
| spellingShingle | Yixun Wang Yixun Wang Yixun Wang Zhaohui Zhang Zhaohui Zhang Zhaohui Zhang Xingguang Qu Xingguang Qu Xingguang Qu Gaosheng Zhou Gaosheng Zhou Gaosheng Zhou Role of the endothelial cell glycocalyx in sepsis-induced acute kidney injury Frontiers in Medicine glycocalyx sepsis endothelium kidney inflammation |
| title | Role of the endothelial cell glycocalyx in sepsis-induced acute kidney injury |
| title_full | Role of the endothelial cell glycocalyx in sepsis-induced acute kidney injury |
| title_fullStr | Role of the endothelial cell glycocalyx in sepsis-induced acute kidney injury |
| title_full_unstemmed | Role of the endothelial cell glycocalyx in sepsis-induced acute kidney injury |
| title_short | Role of the endothelial cell glycocalyx in sepsis-induced acute kidney injury |
| title_sort | role of the endothelial cell glycocalyx in sepsis induced acute kidney injury |
| topic | glycocalyx sepsis endothelium kidney inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1535673/full |
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