Warthin Tumor-Like Papillary Thyroid Carcinoma with a Minor Dedifferentiated Component: Report of a Case with Clinicopathologic Considerations
Warthin tumor-like papillary thyroid carcinoma is an uncommon variant of papillary thyroid carcinoma. We report a rare case of Warthin tumor-like variant of papillary thyroid carcinoma with a dedifferentiated component consisting of a solid tumor area composed of neoplastic cells with a spindle to t...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2010/495281 |
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| author | Paolo Amico Salvatore Lanzafame Giovanni Li Destri Paolo Greco Rosario Caltabiano Giada Maria Vecchio Gaetano Magro |
| author_facet | Paolo Amico Salvatore Lanzafame Giovanni Li Destri Paolo Greco Rosario Caltabiano Giada Maria Vecchio Gaetano Magro |
| author_sort | Paolo Amico |
| collection | DOAJ |
| description | Warthin tumor-like papillary thyroid carcinoma is an uncommon variant of papillary thyroid carcinoma. We report a rare case of Warthin tumor-like variant of papillary thyroid carcinoma with a dedifferentiated component consisting of a solid tumor area composed of neoplastic cells with a spindle to tall cell morphology associated with marked nuclear pleomorphism, atypical mitoses, and foci of necrosis. Although our patient presented with a locally aggressive disease (T3 N1b Mo), she is disease-free without radioiodine therapy after a 23-month follow-up period. We emphasize that Warthin tumor-like papillary thyroid carcinoma, like other morphological variants of papillary carcinoma, may occasionally undergo dedifferentiation. As this component may be only focally detectable, we suggest an extensive sampling of all large-sized (>3 cm) papillary thyroid carcinoma. Recognition of any dedifferentiated component in a Warthin tumor-like papillary thyroid carcinoma should be reported, including its percentage, because it may reflect a more aggressive clinical course. |
| format | Article |
| id | doaj-art-95faf3bb85e34c0c9c020be06d9c057f |
| institution | DOAJ |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-95faf3bb85e34c0c9c020be06d9c057f2025-08-20T03:20:33ZengWileyCase Reports in Medicine1687-96271687-96352010-01-01201010.1155/2010/495281495281Warthin Tumor-Like Papillary Thyroid Carcinoma with a Minor Dedifferentiated Component: Report of a Case with Clinicopathologic ConsiderationsPaolo Amico0Salvatore Lanzafame1Giovanni Li Destri2Paolo Greco3Rosario Caltabiano4Giada Maria Vecchio5Gaetano Magro6Section of Anatomic Pathology, Department G.F. Ingrassia, University of Catania, 95123 Catania, ItalySection of Anatomic Pathology, Department G.F. Ingrassia, University of Catania, 95123 Catania, ItalyDepartment of Surgical Sciences, Organs Transplantation and Advanced Technologies, University of Catania, 95123 Catania, ItalySection of Anatomic Pathology, Department G.F. Ingrassia, University of Catania, 95123 Catania, ItalySection of Anatomic Pathology, Department G.F. Ingrassia, University of Catania, 95123 Catania, ItalySection of Anatomic Pathology, Department G.F. Ingrassia, University of Catania, 95123 Catania, ItalySection of Anatomic Pathology, Department G.F. Ingrassia, University of Catania, 95123 Catania, ItalyWarthin tumor-like papillary thyroid carcinoma is an uncommon variant of papillary thyroid carcinoma. We report a rare case of Warthin tumor-like variant of papillary thyroid carcinoma with a dedifferentiated component consisting of a solid tumor area composed of neoplastic cells with a spindle to tall cell morphology associated with marked nuclear pleomorphism, atypical mitoses, and foci of necrosis. Although our patient presented with a locally aggressive disease (T3 N1b Mo), she is disease-free without radioiodine therapy after a 23-month follow-up period. We emphasize that Warthin tumor-like papillary thyroid carcinoma, like other morphological variants of papillary carcinoma, may occasionally undergo dedifferentiation. As this component may be only focally detectable, we suggest an extensive sampling of all large-sized (>3 cm) papillary thyroid carcinoma. Recognition of any dedifferentiated component in a Warthin tumor-like papillary thyroid carcinoma should be reported, including its percentage, because it may reflect a more aggressive clinical course.http://dx.doi.org/10.1155/2010/495281 |
| spellingShingle | Paolo Amico Salvatore Lanzafame Giovanni Li Destri Paolo Greco Rosario Caltabiano Giada Maria Vecchio Gaetano Magro Warthin Tumor-Like Papillary Thyroid Carcinoma with a Minor Dedifferentiated Component: Report of a Case with Clinicopathologic Considerations Case Reports in Medicine |
| title | Warthin Tumor-Like Papillary Thyroid Carcinoma with a Minor Dedifferentiated Component: Report of a Case with Clinicopathologic Considerations |
| title_full | Warthin Tumor-Like Papillary Thyroid Carcinoma with a Minor Dedifferentiated Component: Report of a Case with Clinicopathologic Considerations |
| title_fullStr | Warthin Tumor-Like Papillary Thyroid Carcinoma with a Minor Dedifferentiated Component: Report of a Case with Clinicopathologic Considerations |
| title_full_unstemmed | Warthin Tumor-Like Papillary Thyroid Carcinoma with a Minor Dedifferentiated Component: Report of a Case with Clinicopathologic Considerations |
| title_short | Warthin Tumor-Like Papillary Thyroid Carcinoma with a Minor Dedifferentiated Component: Report of a Case with Clinicopathologic Considerations |
| title_sort | warthin tumor like papillary thyroid carcinoma with a minor dedifferentiated component report of a case with clinicopathologic considerations |
| url | http://dx.doi.org/10.1155/2010/495281 |
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