CAR T-cell therapy response varies by extranodal disease site in large B-cell lymphoma

CAR T-cell therapy response varies by extranodal disease site in large B-cell lymphoma

Abstract The role of extranodal (EN) sites as potential sanctuary regions resistant to CD19-directed chimeric antigen receptor T-cell (CAR-T) therapy in large B-cell lymphoma (LBCL) remains unclear. To investigate this, we retrospectively analyzed 283 adults treated with commercial CD19 CAR-T therap...

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Main Authors: Alejandro Luna, Sean M. Devlin, Kai Rejeski, Jessica R. Flynn, Magdalena Corona, Efrat Luttwak, Alfredo Rivas-Delgado, Ivan Landego, Giulio Cassanello, Marina Gomez-Llobell, Sandeep S. Raj, Parastoo B. Dahi, Richard J. Lin, Allison Parascondola, M.Lia Palomba, Gunjan L. Shah, Michael Scordo, Ana Alarcon Tomas, Doris Leithner, Akshay Bedmutha, Heiko Schöder, Brandon S. Imber, Gilles Salles, Jae H. Park, Miguel-Angel Perales, Roni Shouval
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Blood Cancer Journal
Online Access:https://doi.org/10.1038/s41408-025-01273-1
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