<i>NELL2</i>-<i>PAX7</i> Transcriptional Cascade Suggests Activation Mechanism for <i>RAD52</i>-Dependent Alternative Lengthening of Telomeres During Malignant Transformation of Malignant Peripheral Nerve Sheath Tumors: Elongation of Telomeres and Poor Survival

<i>NELL2</i>-<i>PAX7</i> Transcriptional Cascade Suggests Activation Mechanism for <i>RAD52</i>-Dependent Alternative Lengthening of Telomeres During Malignant Transformation of Malignant Peripheral Nerve Sheath Tumors: Elongation of Telomeres and Poor Survival

<b>Background</b>: In eukaryotes with a double-stranded linear DNA genome, the loss of terminal DNA during replication is inevitable due to an end-replication problem; here, telomeres serve as a buffer against DNA loss. Thus, the activation of the telomere maintenance mechanism (TMM) is...

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Bibliographic Details
Main Authors: Jungwoo Lee, Eunji Choi, Hyoju Kim, Young-Joon Kim, Seung Hyun Kim
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Biomedicines
Subjects:
telomere
<i>NELL2</i>
<i>PAX7</i>
RAD52-dependent ALT
MPNST
Online Access:https://www.mdpi.com/2227-9059/13/2/281
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