Genetic findings in sport-related concussions: potential for individualized medicine?
Concussion is a traumatic transient disturbance of the brain. In sport, the initial time and severity of concussion is known giving an opportunity for subsequent analysis. Variability in susceptibility and recovery between individual athletes depends, among other parameters, on genetic factors. The...
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| Language: | English |
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Aldus Press
2017-03-01
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| Series: | Concussion |
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| Online Access: | https://www.futuremedicine.com/doi/10.2217/cnc-2016-0020 |
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| author | Jane McDevitt Evgeny Krynetskiy |
| author_facet | Jane McDevitt Evgeny Krynetskiy |
| author_sort | Jane McDevitt |
| collection | DOAJ |
| description | Concussion is a traumatic transient disturbance of the brain. In sport, the initial time and severity of concussion is known giving an opportunity for subsequent analysis. Variability in susceptibility and recovery between individual athletes depends, among other parameters, on genetic factors. The genes-encoding polypeptides that determine incidence, severity and prognosis for concussion are the primary candidates for genetic analysis. Genetic polymorphisms in the genes contributing to plasticity and repair (APOE), synaptic connectivity (GRIN2A), calcium influx (CACNA1E), uptake and deposit of glutamate (SLC17A7) are potential biomarkers of concussion incidence and recovery rate. With catalogued genetic variants, prospective genotyping of athletes at the beginning of their career will allow medical professionals to improve concussion management and return-to-play decisions. |
| format | Article |
| id | doaj-art-95f3e55d9aad4c62a01f5c19eb19aefd |
| institution | DOAJ |
| issn | 2056-3299 |
| language | English |
| publishDate | 2017-03-01 |
| publisher | Aldus Press |
| record_format | Article |
| series | Concussion |
| spelling | doaj-art-95f3e55d9aad4c62a01f5c19eb19aefd2025-08-20T03:19:43ZengAldus PressConcussion2056-32992017-03-012110.2217/cnc-2016-0020Genetic findings in sport-related concussions: potential for individualized medicine?Jane McDevitt0Evgeny Krynetskiy11East Stroudsburg University, Athletic Training Department, East Stroudsburg, PA 18301, USA2Temple University School of Pharmacy, Pharmaceutical Sciences Department, Philadelphia, PA 19140, USAConcussion is a traumatic transient disturbance of the brain. In sport, the initial time and severity of concussion is known giving an opportunity for subsequent analysis. Variability in susceptibility and recovery between individual athletes depends, among other parameters, on genetic factors. The genes-encoding polypeptides that determine incidence, severity and prognosis for concussion are the primary candidates for genetic analysis. Genetic polymorphisms in the genes contributing to plasticity and repair (APOE), synaptic connectivity (GRIN2A), calcium influx (CACNA1E), uptake and deposit of glutamate (SLC17A7) are potential biomarkers of concussion incidence and recovery rate. With catalogued genetic variants, prospective genotyping of athletes at the beginning of their career will allow medical professionals to improve concussion management and return-to-play decisions.https://www.futuremedicine.com/doi/10.2217/cnc-2016-0020MTBISNPssports medicineTBI |
| spellingShingle | Jane McDevitt Evgeny Krynetskiy Genetic findings in sport-related concussions: potential for individualized medicine? Concussion MTBI SNPs sports medicine TBI |
| title | Genetic findings in sport-related concussions: potential for individualized medicine? |
| title_full | Genetic findings in sport-related concussions: potential for individualized medicine? |
| title_fullStr | Genetic findings in sport-related concussions: potential for individualized medicine? |
| title_full_unstemmed | Genetic findings in sport-related concussions: potential for individualized medicine? |
| title_short | Genetic findings in sport-related concussions: potential for individualized medicine? |
| title_sort | genetic findings in sport related concussions potential for individualized medicine |
| topic | MTBI SNPs sports medicine TBI |
| url | https://www.futuremedicine.com/doi/10.2217/cnc-2016-0020 |
| work_keys_str_mv | AT janemcdevitt geneticfindingsinsportrelatedconcussionspotentialforindividualizedmedicine AT evgenykrynetskiy geneticfindingsinsportrelatedconcussionspotentialforindividualizedmedicine |